Role of residues constituting the 2β1 strand of domain II in the biological activity of anthrax protective antigen

FEMS Microbiology Letters

Volumn 199, Issue 1, 2001, Pages 27-31

  Khanna, Hemant ^a,b   Chopra, Arun P ^a   Arora, Naveen ^a   Chaudhry, Ashutosh ^b   Singh, Yogendra ^a  

^a CSIR INSTITUTE OF GENOMICS AND INTEGRATIVE BIOLOGY   (India)

^b UNIVERSITY OF DELHI   (India)

Author keywords

Anthrax toxin; Iota toxin; Lethal factor; Protective antigen; Translocation

Indexed keywords

ALANINE; ANTHRAX TOXIN; BACTERIAL ANTIGEN; MUTANT PROTEIN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BACTERIAL MEMBRANE; CLOSTRIDIUM PERFRINGENS; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; DRUG ACTIVITY; GENE TRANSLOCATION; LETHAL GENE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SEQUENCE HOMOLOGY;

ANTHRAX; CLOSTRIDIUM PERFRINGENS;

EID: 0035872906     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1097(01)00152-5     Document Type: Article

References (15)

1. Leppla, S.H. (1999) The bifactorial Bacillus anthracis lethal and oedema toxins. In: Comprehensive Sourcebook of Bacterial Protein Toxins (Alouf, J.E. and Freer, J.H., Eds.), pp. 243–263. Academic Press, London.
2. S.H. Leppla Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cAMP concentration in eukaryotic cells Proc. Natl. Acad. Sci. USA 79 1982 3162 3166
3. A.M. Friedlander Macrophages are sensitive to anthrax lethal toxin through an acid-dependent process J. Biol. Chem. 261 1986 7123 7126
4. C. Petosa R.J. Collier K.R. Klimpel S.H. Leppla R.C. Liddington Crystal structure of the anthrax toxin protective antigen Nature 385 1997 833 838
5. Y. Singh V.K. Chaudhary S.H. Leppla A deleted variant of Bacillus anthracis protective antigen is non-toxic and blocks anthrax toxin action in vivo J. Biol. Chem. 264 1989 19103 19107
6. 315, in anthrax toxin protective antigen is required for translocation of lethal factor J. Biol. Chem. 269 1994 29039 29046
7. Y. Singh K.R. Klimpel C.P. Quinn V.K. Chaudhary S.H. Leppla The carboxyl-terminal end of protective antigen is required for receptor binding and anthrax toxin activity J. Biol. Chem. 266 1991 15493 15497
8. Y. Singh K.R. Klimpel S. Goel P.K. Swain S.H. Leppla Oligomerization of anthrax toxin protective antigen and binding of lethal factor during endocytic uptake into mammalian cells Infect. Immun. 67 1999 1853 1859
9. S. Perelle M. Gibert P. Boquet M.R. Popoff Characterization of Clostridium perfringens iota toxin genes and expression in Escherichia coli Infect. Immun. 61 1993 5147 5156
10. M. Sharma P.K. Swain A.P. Chopra V.K. Chaudhary Y. Singh Expression and purification of anthrax protective antigen from Escherichia coli Protein Express. Purif. 7 1995 33 38
11. J. Wesche J.L. Elliott P.Ø. Falnes S. Olsnes R.J. Collier Characterization of membrane translocation by anthrax protective antigen Biochemistry 37 1998 15737 15746
12. C. Lesieur B. Vecsey-Semjen L. Abrami M. Fivaz F.G. van der Goot Membrane insertion: the strategies of toxins J. Membr. Biol. 14 1997 45 64
13. J.C. Milne D. Furlong P.C. Hanna J.S. Wall R.J. Collier Anthrax protective antigen forms oligomers during intoxication of mammalian cells J. Biol. Chem. 269 1994 20607 20612
14. X.M. Wang R. Wattiez F. Brossier M. Mock P. Falmagne J.M. Ruysschaert V. Cabiaux Use of a photoactivatable lipid to probe the topology of PA63 of Bacillus anthracis in lipid membranes Eur. J. Biochem. 256 1998 179 183
15. M. Sharma H. Khanna N. Arora Y. Singh Anthrax toxin-mediated delivery of cholera toxin A subunit into the cytosol of mammalian cells Biotechnol. Appl. Biochem. 32 2000 69 72