GTP cyclohydrolase I mRNA: Novel splice variants in the slime mould Physarum polycephalum and in human monocytes (THP-1) indicate conservation of mRNA processing

Biochemical Journal

Volumn 355, Issue 2, 2001, Pages 499-507

  Golderer, G ^a   Werner, E R ^a   Heufler, C ^a   Strohmaier, W ^a   Grobner P ^a   Werner Felmayer, G ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Exon intron structure; Splicing; Tetrahydrobiopterin

Indexed keywords

AMINO ACIDS; BACTERIA; BIOSYNTHESIS; CELLS; ENZYMES; RNA;

HETEROLOGOUS EXPRESSIONS;

BIOCHEMISTRY;

BIOPTERIN; FOLIC ACID; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; TETRAHYDROBIOPTERIN;

3' UNTRANSLATED REGION; ALTERNATIVE RNA SPLICING; ARTICLE; ENZYME ACTIVITY; EXON; GENE STRUCTURE; GENETIC ANALYSIS; INTRON; MONOCYTE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHYSARUM POLYCEPHALUM; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RNA PROCESSING; WESTERN BLOTTING;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; EXONS; GTP CYCLOHYDROLASE; HUMANS; INTRONS; MOLECULAR SEQUENCE DATA; MONOCYTES; PHYSARUM POLYCEPHALUM; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 0035871215     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3550499     Document Type: Article

References (40)

1. Biosynthesis and metabolism of tetrahydrobiopterin and molybdopterin
2. 12
3. Tetrahydrobiopterin biosynthesis, regeneration and functions
4. Tetrahydrobiopterin, cytokines, and nitric oxide synthesis
5. Multiple mRNAs from the punch locus of Drosophila melanogaster encode isoforms of GTP cyclohydrolase I with distinct N-terminal domains
6. Biosynthesis of pteridines in Neurospora crassa, Phycomyces blakesleeanus and Euglena gracilis: Detection and characterization of biosynthetic enzymes
7. Tetrahydrobiopterin, the cofactor for aromatic amino acid hydroxylases, is synthesized by and regulates proliferation of erythroid cells
8. Synthesis of tetrahydrobiopterin in Friend erythroleukemia cells and its modulator effect on cell proliferation
9. Regulation of melanin biosynthesis in the human epidermis by tetrahydrobiopterin
10. Dopamine-releasing action of 6R-L-erythro-tetrahydrobioplerin: Analysis of its action site using seplapterin
11. L-threo-neopterin, the major pterin in Escherichia coli B
12. UV-A-induced expression of GroEL in the UV-A-resistant marine cyanobacterium Oscillatoria sp. NKBG091800
13. Pteridine biosynthesis and nitric oxide synthase in Physarum polycephalum
14. Sequence of GTP cyclohydrolase I from Escherichia coli
15. Cloning and sequencing of cDNA encoding rat GTP cyclohydrolase I: The first enzyme of the tetrahydrobiopterin biosynthetic pathway
16. Multiple mRNA forms of human GTP cyclohydrolase I
17. Isolation of a full-length cDNA clone for human GTP cyclohydrolase I type 1 from pheochromocytoma
18. Cloning and sequencing of cDNA encoding mouse GTP cyclohydrolase I
19. Molecular cloning of a cDNA coding for GTP cyclohydrolase I from Dictyostelium discoideum
20. Characterization of mouse and human GTP cyclohydrolase I genes
21. Cloning, sequencing and functional studies of the gene encoding human GTP cyclohydrolase I
22. Disruption of the GTP cyclohydrolase I gene in Saccharomyces cerevisiae
23. Identification and characterization of basal and cyclic AMP response elements in the promoter of the rat GTP cyclohydrolase I gene
24. Methods of culture for plasmodial myxomycetes
25. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
26. Homology cloning of GTP cyclohydrolase I from various unrelated eukaryotes by reverse-transcription polymerase chain reaction using a general set of degenerate primers
27. Differential splicing of the GTP cyclohydrolase I RNA in Dopa-responsive dystonia
28. Human GTP cyclohydrolase I: Only one out of three cDNA isoforms gives rise to the active enzyme
29. Nucleotide sequence of the Physarum polycephalum small subunit ribosomal RNA as inferred from the gene sequence: Secondary structure and evolutionary implications
30. Determination of tetrahydrobiopterin biosynthetic activities by high-performance liquid chromatography with fluorescence detection
31. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
32. ArgtRNAs
33. Purification and characterization of rat liver GTP cyclohydrolase I
34. Active site topology and reaction mechanism of GTP cyclohydrolase I
35. Exon-intron organization of genes in the slime mold Physarum polycephalum
36. Origin and evolution of the slime molds (Mycetozoa)
37. Phosphorylation of GTP cyclohydrolase I and modulation of its activity in rodent mast cells
38. Protein kinase C phosphorylates and activates GTP cyclohydrolase I in rat renal mesangial cells
39. Lipopolysaccharide treatment in vivo induces tissue expression of GTP cyclohydrolase I mRNA
40. Species and tissue specificity of mammalian GTP cyclohydrolase I messenger RNA