Tissue responses around polymethylmethacrylate particles implanted into bone: Analysis of expression of bone matrix protein mRNAs by in situ hybridization

Journal of Biomedical Materials Research

Volumn 54, Issue 4, 2001, Pages 501-508

  Ohsawa, K ^a   Neo, M ^a   Matsuoka, H ^a   Akiyama, H ^a   Ito, H ^a   Nakamura, T ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Biocompatibility; In situ hybridization; Macrophage; Osteoblast differentiation; Polymethylmethacrylate

Indexed keywords

BIOMATERIAL; BONE CEMENT; DIGOXIGENIN; MESSENGER RNA; OSTEOCALCIN; OSTEONECTIN; OSTEOPONTIN; POLY(METHYL METHACRYLATE); PROCOLLAGEN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCOMPATIBILITY; BONE MATRIX; CELL DIFFERENTIATION; HISTOLOGY; IMPLANT; IN SITU HYBRIDIZATION; MACROPHAGE; NONHUMAN; ORTHOPEDIC SURGERY; OSTEOBLAST; PROTEIN EXPRESSION; RAT; TIBIA;

ANIMALS; BIOCOMPATIBLE MATERIALS; BONE MATRIX; BONE SUBSTITUTES; IN SITU HYBRIDIZATION; MALE; OSTEOCALCIN; OSTEONECTIN; OSTEOPONTIN; POLYMETHYL METHACRYLATE; PROCOLLAGEN; RATS; RATS, WISTAR; RNA, MESSENGER; SIALOGLYCOPROTEINS; TIBIA; TRANSCRIPTION, GENETIC;

EID: 0035869770     PISSN: 00219304     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-4636(20010315)54:4<501::AID-JBM50>3.0.CO;2-C     Document Type: Article

References (37)

1. Calcium phosphate ceramics as hard tissue prosthesis
2. Differences in ceramic-bone interface between surface-active ceramics and resorbable ceramics: A study by scanning and transmission electron microscopy
3. Comparative bone growth behavior in granules of bioceramic materials of various sizes
4. Temporal and spatial patterns of osteoblast activation following implantation of beta-TCP particles into bone
5. Osteoblast reaction at the interface between surface-active materials and bone in vivo: A study using in situ hybridization
6. Analysis of osteoblast activity at biomaterial-bone interfaces by in situ hybridization
7. The expression of bone matrix protein mRNAs around β-TCP particles implanted into bone
8. The effect of polymethylmethacrylate on bone: An experimental study
9. The effects of bulk versus particulate polymethylmethacrylate on bone
10. Cement particles inhibit bone growth into titanium chambers implanted in the rabbit
11. Microstructural investigation of bone-cement interface
12. The effect of intramedullary polymethylmethacrylate on healing of intercalary cortical allografts in a canine model
13. Properties of acrylic bone cement: State of the art review
14. Bioactive bone cements
15. Polymethylmethacrylate-based bone cement modified with hydroxyapatite
16. Effect of saline treatment and different resin compositions on biological properties of bioactive bone cement containing apatite-wollastonite glass ceramic powder
17. Osteoblast responses to orthopedic implant materials in vitro
18. Response of human osteoblasts to polymethylmetacrylate in vitro
19. Construction of DNA sequences complementary to rat alpha 1 and alpha 2 collagen mRNA and their use in studying the regulation of type I collagen synthesis by 1,25-dihydroxyvitamin D
20. Developmental expression of 2ar (osteopontin) and SPARC (osteonectin) RNA as revealed by in situ hybridization
21. Expression of genes for non-collagenous proteins during embryonic bone formation
22. Alterations in the expression of osteonectin, osteopontin, and osteocalcin mRNAs during the development of skeletal tissues in viva
23. Localization of the mRNA for bone matrix proteins during fracture healing as determined by in situ hybridization
24. Expression of bone matrix proteins mRNA during distraction osteogenesis
25. Pattern of gene expression following rat tibial marrow ablation
26. In situ hybridization to show sequential expression of osteoblast gene markers during bone formation in vivo
27. Mineralization and the expression of matrix proteins during in vivo bone development
28. Human osteoclasts, not osteoblasts, deposit osteopontin onto resorption surfaces: An in vitro and ex vivo study of remodeling bone
29. Osteopontin expression and function: Role in bone remodeling
30. Spatial and temporal distribution of CD44 and osteopontin in fracture callus
31. Secretion of Osteopontin by macrophages and its accumulation at tissue surfaces during wound healing in mineralized tissues: A potential requirement for macrophage adhesion and phagocytosis
32. Regulation of osteopontin expression in osteoblasts
33. Stable acid phosphatase. I. Demonstration and distribution
34. Histological and biochemical evaluation of osteogenic response in porous hydroxyapatite coated alumina ceramics
35. In vitro modeling of the bone/implant interface
36. In vivo inflammatory response to polymethylmethacrylate particulate debris: Effect of size, morphology, and surface area
37. Inflammatory response to implant particulates in a macrophage/osteoblast coculture model