A structural difference limited to one residue of the antigenic peptide can profoundly alter the biological outcome of the TCR-peptide/MHC class I interaction

Journal of Immunology

Volumn 166, Issue 6, 2001, Pages 3994-3997

  Thomson, C T ^a   Kalergis, A M ^a   Sacchettini, J C ^a   Nathenson, S G ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMIC ACID; GLUTAMINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; T LYMPHOCYTE RECEPTOR; VIRUS PROTEIN;

AMINO ACID SUBSTITUTION; ANTIGEN RECOGNITION; ARTICLE; COMPLEMENTARITY DETERMINING REGION; CONFORMATIONAL TRANSITION; CYTOTOXIC T LYMPHOCYTE; HYBRIDOMA; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS; VESICULAR STOMATITIS VIRUS;

EID: 0035869451     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.6.3994     Document Type: Article

References (22)

1. Altered peptide ligand-induced partial T cell activation: Molecular mechanisms and role in T cell biology
2. Altered peptide ligand design: Altering immune responses to class I MHC/peptide complexes
3. Rational antigen modification as a strategy to upregulate or downregulate antigen recognition
4. Alterations in TCR-MHC contacts subsequent to cross-recognition of class I MHC and singly substituted peptide variants
5. On defining the rules for interactions between the T cell receptor and its ligand: A critical role for a specific amino acid residue of the T cell receptor β-chain
6. + cytotoxic lymphocyte population
7. Altered peptide ligand-mediated TCR antagonism can be modulated by a change in a single amino acid residue within the CDR3β of an MHC I-restricted TCR
8. b molecule containing a single viral peptide: Implications for peptide binding and T-cell receptor recognition
9. A simplified procedure for the preparation of MHC/peptide tetramers: Chemical biotinylation of an unpaired cysteine engineered at the C-terminus of MHC-I
10. b
11. AMoRe: An automated package for molecular replacement
12. Refinement of the influenza virus hemagglutinin by simulated annealing
13. Improved methods for binding protein models in electron density maps and the location of errors in these models
14. Ligand recognition by αβ T cell receptors
15. Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids
16. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2
17. Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen
18. Antagonist HIV-1 Gag peptides induce structural changes in HLA B8
19. Differential thymic selection outcomes stimulated by focal structural alteration in peptide/major histocompatibility complex ligands
20. Four A6-TCP/peptide/HLA-A2 structures that generate very different T cell signals are nearly identical
21. The structural basis for the increased immunogenicity of two HIV-reverse transcriptase peptide variant/class I major histocompatibility complexes
22. T cell receptor interaction with peptide/major histocompatibility complex (MHC) and superantigen/MHC ligands is dominated by antigen