Quinolones as gonadotropin releasing hormone (GnRH) antagonists: Simultaneous optimization of the C(3)-aryl and C(6)-substituents

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 15, 2000, Pages 1723-1727

  Young, Jonathan R ^a   Huang, Song X ^a   Chen, Irene ^a   Walsh, Thomas F ^a   DeVita, Robert J ^a   Wyvratt Jr , Matthew J ^a   Goulet, Mark T ^a   Ren, Ning ^a   Lo, Jane ^a   Yang, Yi Tien ^a   Yudkovitz, Joel B ^a   Cheng, Kang ^a   Smith, Roy G ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GONADORELIN ANTAGONIST; QUINOLONE;

ARTICLE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

GONADOTROPIN-RELEASING HORMONE; QUINOLONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034618152     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00318-8     Document Type: Article

References (15)