Mechanism of functional inactivation of a Li-Fraumeni syndrome p53 that has a mutation outside of the DNA-binding domain

Cancer Research

Volumn 61, Issue 4, 2001, Pages 1741-1746

  Gu, Jijie ^a   Kawai, Hidehiko ^a   Wiederschain, Dmitri ^a   Yuan, Zhi Min ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

KARYOPHERIN; MUTANT PROTEIN; PROTEIN P53;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA BINDING; DNA DAMAGE; FAMILIAL CANCER; GENE CONSTRUCT; GENE INACTIVATION; GENE MUTATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; NUCLEAR IMPORT; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; TRANSACTIVATION;

3T3 CELLS; ANIMALS; APOPTOSIS; CELL DIVISION; CYTOPLASM; DNA; DNA DAMAGE; EXONS; GENE EXPRESSION REGULATION; GENE SILENCING; GENES, P53; HUMANS; LI-FRAUMENI SYNDROME; MICE; MUTATION; NUCLEAR PROTEINS; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; RATS; TRANS-ACTIVATION (GENETICS); TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0035866340     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Soft-tissue sarcomas, breast cancer, and other neoplasms: A familial syndrome
2. Germ line p53 mutation in a familial syndrome of breast cancer, sarcomas, and other neoplasms
3. Prevalence and diversity of constitutional mutations in the p53 gene among 21 Li-Fraumeni families
4. P53: The cellular gatekeeper for growth and division
5. UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells
6. Signaling to p53: Breaking the Mdm2-p53 circuit
7. Identification of a sequence element from p53 that signals for Mdm2-targeted degradation
8. Nucleocytoplamic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein vial a pathway used by the human immunodeficiency virus rev protein
9. A bipartite nuclear localization signal is required for p53 nuclear import regulated by a carboxyl-terminal domain
10. The tumor suppressor p53 is subject to both nuclear import and export, and both are fast, energy-dependent, and lectin-inhibited
11. Importins and exportins: How to get in and out of the nucleus
12. Nuclear accumulation of p53 protein is mediated by several nuclear localization signals and plays a role in tumorigenesis