Evidence of porcine endogenous retroviruses in porcine factor VIII and evaluation of transmission to recipients with hemophilia

Journal of Infectious Diseases

Volumn 183, Issue 4, 2001, Pages 648-652

  Heneine, Walid ^a   Switzer, William M ^a   Soucie, J Michael ^a   Evatt, Bruce L ^a   Shanmugam, Vedapuri ^a   Rosales, Guillermo Vazquez ^a   Matthews, Aprille ^a   Sandstrom, Paul ^a   Folks, Thomas M ^a  

^a NATL CENTER FOR INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 8 CONCENTRATE; ENVELOPE PROTEIN; VIRUS RNA;

ANTIBODY DETECTION; ARTICLE; BLOOD DONOR; BLOOD SAMPLING; BLOOD TRANSFUSION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; HEMOPHILIA; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MAJOR CLINICAL STUDY; MULTICENTER STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RETROVIRUS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SEQUENCE; SWINE; VIRUS INFECTION; VIRUS TRANSMISSION;

ANIMALS; ANTIBODIES, VIRAL; DRUG CONTAMINATION; ENDOGENOUS RETROVIRUSES; FACTOR VIII; HEMOPHILIA A; HUMANS; MOLECULAR SEQUENCE DATA; PLASMA; RETROVIRIDAE INFECTIONS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, VIRAL; SWINE; SWINE DISEASES;

EID: 0035865888     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/318540     Document Type: Article

References (15)

1. Emerging issues in blood safety
2. Transfusion-transmitted diseases: Risks, prevention and perspectives
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4. Use of porcine factor VIII in the treatment of patients with acquired hemophilia
5. Investigation of porcine parvovirus among persons with hemophilia receiving Hyate:C porcine factor VIII concentrate
6. Infection of human cells by an endogenous retrovirus of pigs
7. Two sets of human-tropic pig retrovirus
8. Type C retrovirus released from porcine primary peripheral blood mononuclear cells infects human cells
9. Host range and interference studies of three classes of pig endogenous retrovirus
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11. Polymerase chain reaction assays for the diagnosis of infection with the porcine endogenous retrovirus and the detection of pig cells in human and nonhuman recipients of pig xenografts
12. Development and validation of a Western immunoblot assay for detection of antibodies to porcine endogenous retrovirus
13. Detection of HIV-1 by RNA PCR in factor VIII concentrates
14. HIV transmission to patients with hemophilia by heat-treated, donor-screened factor concentrate
15. Recovery and inactivation of infectious retroviruses added to factor VIII concentrates