Hypochlorous acid damages erythrocyte membrane proteins and alters lipid bilayer structure and fluidity

Free Radical Biology and Medicine

Volumn 30, Issue 4, 2001, Pages 363-369

  Zavodnik, Ilya B ^a,b   Lapshina, Elena A ^a,b   Zavodnik, Lev B ^a,b   Bartosz, Grzegorz ^b   Soszynski, Miroslaw ^b   Bryszewska, Maria ^b  

^a INSTITUTE OF BIOCHEMISTRY   (Belarus)

^b UNIVERSITY OF LODZ   (Poland)

Author keywords

ATPase; Erythrocyte; Fluorescence; Free radicals; Hypochlorous acid; Membrane; Thiol group

Indexed keywords

ADENOSINE TRIPHOSPHATASE (MAGNESIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ERYTHROCYTE BAND 4.1 PROTEIN; HYPOCHLOROUS ACID; MEMBRANE PROTEIN; THIOL; TOSYLCHLORAMIDE SODIUM; TRYPTOPHAN;

ARTICLE; BLOOD TOXICITY; CELL SWELLING; CONCENTRATION RESPONSE; CONTROLLED STUDY; ECHINOCYTE; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME METABOLISM; ERYTHROCYTE MEMBRANE; HEMOLYSIS; HUMAN; HUMAN CELL; ION TRANSPORT; LIPID BILAYER; MEMBRANE FLUIDITY; MEMBRANE STRUCTURE; NORMAL HUMAN; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATASES; CHLORAMINES; ERYTHROCYTE MEMBRANE; FLUORESCENCE POLARIZATION; FREE RADICALS; HEMOLYSIS; HUMANS; HYPOCHLOROUS ACID; LIPID BILAYERS; MEMBRANE FLUIDITY; MEMBRANE PROTEINS; TOSYL COMPOUNDS;

EID: 0035865878     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(00)00479-2     Document Type: Article

References (30)

1. Phagocytic killing of microorganisms by radical processes: Consequences of the reaction of hydroxyl radicals with chloride yielding chlorine atoms
2. Mechanism of activation of the respiratory burst oxidase
3. Phagocytic cells: Products of oxygen metabolism
4. Potential roles of hypochlorous acid and N-chloroamines in collagen breakdown by phagocytic cells in synovitis
5. Hypochlorous acid inhibits Ca(2+)-ATPase from skeletal muscle sarcoplasmic reticulum
6. Hypochlorous acid as reactive oxygen species
7. Oxidation of intracellular glutathione after exposure of human red blood cells to hypochlorous acid
8. Characterization of the oxidation products of the reaction between reduced glutathione and hypochlorous acid
9. Hypochlorite-induced damage to proteins: Formation of nitrogen-centred radicals from lysine residues and their role in protein fragmentation
10. Reaction of HOCl with amino acids and peptides: EPR evidence for rapid rearrangement and fragmentation reactions of nitrogen-centered radicals
11. Chlorination of cholesterol in cell membranes by hypochlorous acid
12. Modification of red cell membrane lipids by hypochlorous acid and haemolysis by preformed lipid chlorohydrins
13. Mechanisms of hypochlorite injury of target cells
14. Membrane changes associated with lysis of red blood cells by hypochlorous acid
15. Comparison of human red cell lysis by hypochlorous and hypobromous acids: Insights into the mechanism of lysis
16. Inhibition of the Ca pump of intact red blood cells by t-butyl hydroperoxide: Importance of glutathione peroxidase
17. Inhibition by activated neutrophils of the Ca2+ pump ATPase of intact red blood cells
18. (+)-ATPase by a free radical generating system containing t-butylhydroperoxide
19. Peroxyl radical-mediated hemolysis: Role of lipid, protein and sulfhydryl oxidation
20. Effect of peroxynitrite on erythrocytes
21. The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes
22. The acid ionization constant of HOCl from 5 degree to 35 degree
23. Tissue sulfhydryl groups
24. A malachite green procedure for orthophosphate determination and its use in alkaline phosphatase-based enzyme immunoassay
25. Protein measurement with the Folin phenol reagent
26. Lipid structural order parameters (reciprocal of fluidity) in biomembranes derived from steady-state fluorescence polarization measurements
27. A comparison of the fluorescence properties of TMA-DPH as a probe for plasma membrane and for endocytic membrane
28. +-pump ATPase by iron-generated free radicals. Protection by 6,7-dimethyl-2,4-DI-1-pyrrolidinyl-7H-pyrrolo[2,3-d] pyrimidine sulfate (U-89843D), a potent, novel, antioxidant/free radical scavenger
29. Mechanism of depression in cardiac sarcolemmal Na+-K+-ATPase by hypochlorous acid
30. (2+)-atpase activities from the human erythrocyte membrane