Inhibition of Ca2+-pump ATPase and the Na+/K+-pump ATPase by iron-generated free radicals: Protection by 6,7-dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3-d]pyrimidine sulfate (U-89843D), a potent, novel, antioxidant/free radical scavenger

Biochemical Pharmacology

Volumn 51, Issue 4, 1996, Pages 471-476

  Rohn, Troy T ^a   Hinds, Thomas R ^a   Vincenzi, Frank F ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Antioxidant; Calcium pump; Free radical; Lipid peroxidation; Membrane; Sodium potassium pump

Indexed keywords

6,7 DIMETHYL 2,4 BIS(1 PYRROLIDINYL) 7H PYRROLO[2,3 D]PYRIMIDINE; ADENOSINE TRIPHOSPHATASE (CALCIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ANTIOXIDANT; BUTYLCRESOL; CALMODULIN; DEFEROXAMINE; DIMETHYL SULFOXIDE; EDETIC ACID; FERROUS SULFATE; FREE RADICAL; REACTIVE OXYGEN METABOLITE; SOLVENT; THIOBARBITURIC ACID REACTIVE SUBSTANCE; U 89843D; UNCLASSIFIED DRUG; FE(II) EDTA; FE(II)-EDTA; FERROUS ION; MEMBRANE PROTEIN; PREGNANE DERIVATIVE; PYRIMIDINE DERIVATIVE; PYRROLE DERIVATIVE; SCAVENGER; TIRILAZAD; U 89843;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME INHIBITION; ERYTHROCYTE MEMBRANE; HUMAN; HUMAN TISSUE; ION TRANSPORT; LIPID PEROXIDATION; PRIORITY JOURNAL; PROTECTION; PROTEIN CROSS LINKING; BLOOD; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; ISOLATION AND PURIFICATION; KINETICS; POLYACRYLAMIDE GEL ELECTROPHORESIS; WESTERN BLOTTING;

ANTIOXIDANTS; BLOTTING, WESTERN; CALCIUM-TRANSPORTING ATPASES; EDETIC ACID; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ERYTHROCYTE MEMBRANE; FERROUS COMPOUNDS; FREE RADICAL SCAVENGERS; FREE RADICALS; HUMANS; KINETICS; MEMBRANE PROTEINS; NA(+)-K(+)-EXCHANGING ATPASE; PREGNATRIENES; PYRIMIDINES; PYRROLES; REACTIVE OXYGEN SPECIES; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 0029664721     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(95)02222-8     Document Type: Article

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