Nitric oxide synthase inhibitors have opposite effects on acute inflammation depending on their route of administration

Journal of Immunology

Volumn 166, Issue 2, 2001, Pages 1169-1177

  Paul Clark, M J ^a   Gilroy, D W ^a   Willis, D ^a   Willoughby, D A ^a   Tomlinson, A ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARRAGEENAN; HISTAMINE; LEUKOTRIENE B4; NITRIC OXIDE SYNTHASE INHIBITOR; PROSTAGLANDIN SYNTHASE; SCAVENGER; SUPEROXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ADMINISTRATION ROUTE; ENZYME ACTIVITY; INFLAMMATION; MALE; NONHUMAN; PLEURA CAVITY; PLEURISY; PRIORITY JOURNAL; RAT;

EID: 0035863910     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.2.1169     Document Type: Article

References (42)

1. Nitric oxide: Physiology, pathophysiology and pharmacology
2. Apparent hydroxyl production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
3. Nitric oxide: An endogenous modulator of leukocyte adhesion
4. Possible role of nitric oxide in 5-hydroxytryptamine-induced increase in vascular permeability in mouse skin
5. Modulation of acute inflammation by endogenous nitric oxide
6. The nitric oxide synthase inhibitor, L-ng-monomethylargine, reduces carrageenan-induced pleunsy in the rat
7. Nitric oxide: A key me diator in the early and late phase of carrageenan-induced rat paw inflammation
8. Nitric oxide modulates sympathetic vasoconstriction and basal blood flow in normal and acutely inflamed rabbit knee joints
9. Effect of the inducible nitric oxide synthase inhibitors aminoguanidine and L-n6-(1-iminoethyl)lysine on zymosan-induced plasma extravasation in rat skin
10. Cyclo-oxygenase and nitric oxide synthase isoforms in rat carrageenin-induced pleurisy
11. Isothioureas: Potent inhibitors of nitric oxide synthases with variable isoform selectivity
12. 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo
13. Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo
14. The demonstration of the role of mediators in turpentine pleurisy in rats by experimental suppression of the inflammatory changes
15. Temporal expression of pro-inflammatory cytokines and inducible nitric oxide synthase in experimental acute chagasic cardiomyopathy
16. Physiological assay of plasma total antioxidant status in a model of endothelial dysfunction in the rat following experimental oxidant stress in vivo
17. Microassay of superoxide anion scavenging activity in vitro
18. Inducible cyclooxygenase may have anti-inflammatory properties
19. Rat CINC, a member of the interleukin-8 family, is a neutrophil-specific chemoattractant in vivo
20. Interaction between nitric oxide and cyclooxygenase pathways
21. Use of antioxidant therapy in shock and trauma
22. Interactions of peroxynitrite with human plasma and its constituents: Oxidative damage and anti-oxidant depletion
23. The selective beneficial effects of nitric oxide synthase inhibition in experimental colitis
24. Pharmacological characterization of polycation-induced rat hind-paw oedema
25. Inducible nitric oxide synthase plays a critical role in resolving intestinal inflammation
26. Inducible nitric oxide synthase-deficient mice have enhanced leukocyte-endothelium interactions in endotoxemia
27. Further studies on carrageenan-induced pleurisy in rats
28. Reactive oxygen species generation and histamine release by activated mast cells: Modulation by NOS inhibition
29. Nitric oxide inhibits numerous features of mast cell-induced inflammation
30. Cytokine-induced neutrophil chemoattractant mediates neutrophilic alveolitis in rats: Association with nuclear factor κB activation
31. Functional characterization of the rat chemokine KC and its importance in neutrophil recruitment in a rat model of pulmonary inflammation
32. Actions of nitric oxide on the release of prostacyclin from bovine endothelial cells in culture
33. Inhibition by nitric oxide-donors of human polymorphonuclear leukocyte functions
34. Nitric oxide reversibly suppresses xanthine oxidase activity
35. Nitric oxide prevents leukocyte adherence: Role of superoxide
36. Inhaled nitric oxide prevents neurophol-mediated, oxygen radical-dependent leak in isolated rat lungs
37. Nitric oxide inhibits superoxide production by inflammatory polymorphonuclear leukocytes
38. Inhibition of nitric oxide synthesis aggravates hepatic oxidative stress and enhances superoxide dismutase inactivation in rats subjected to tourniquet shock
39. Mast cells as a source of superoxide anions and nitric oxide-like factor: Relevance to histamine release
40. 4 dependent mechanism
41. Antioxidant and redox regulation of gene transcription
42. In vivo antioxidant treatment supresses nuclear factor-κB activation and neutrophilic lung inflammation