Immune complex stimulation of neutrophil apoptosis: Investigating the involvement of oxidative and nonoxidative pathways

Free Radical Biology and Medicine

Volumn 30, Issue 2, 2001, Pages 161-169

  Ottonello, Luciano ^a,b   Frumento, Guido ^b   Arduino, Nicoletta ^c   Dapino, Patrizia ^a   Tortolina, Giuseppe ^a   Dallegri, Franco ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c UNIVERSITY OF GENOA   (Italy)

Author keywords

Apoptosis; Fc R; Free radicals; Immune complexes; Neutrophils; Oxidants

Indexed keywords

ANTIOXIDANT; CATALASE; FC RECEPTOR; FREE RADICAL; IMMUNOGLOBULIN FC FRAGMENT; OXIDIZING AGENT; REACTIVE OXYGEN METABOLITE;

AEROBIC METABOLISM; ANTIGEN ANTIBODY COMPLEX; APOPTOSIS; ARTICLE; CELL SURVIVAL; CHRONIC GRANULOMATOUS DISEASE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNE COMPLEX DEPOSITION; INFLAMMATORY DISEASE; NEUTROPHIL; PATHOGENESIS; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGEN-ANTIBODY COMPLEX; ANTIOXIDANTS; APOPTOSIS; CASPASE 3; CASPASES; CATALASE; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; FLOW CYTOMETRY; FLUORESCEINS; GRANULOMATOUS DISEASE, CHRONIC; HUMANS; INFLAMMATION; NEUTROPHILS; OXIDATION-REDUCTION; RABBITS; REACTIVE OXYGEN SPECIES; RECEPTORS, IGG; SIGNAL TRANSDUCTION;

EID: 0035863028     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(00)00453-6     Document Type: Article

References (40)

1. Neutrophils and host defense
2. Tissue injury in inflammation: Oxidants, proteinases and cationic proteins
3. Role of granulocytes in immune complex-induced tissue injuries
4. γR
5. Monoclonal antibody to human IgG Fc receptors. Cross-linking of receptors induces lysosomal enzyme release and superoxide generation by neutrophils
6. Tissue destruction by neutrophils
7. Tissue injury in neutrophilic inflammation
8. Resolution of acute inflammation and the role of apoptosis in the tissue fate of granulocytes
9. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-β, PGE2, and PAF
10. Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products
11. Inhibition of apoptosis and prolongation of neutrophil functional longevity by inflammatory mediators
12. Involvement of reactive oxygen intermediates in spontaneous and CD95 (Fas/Apo-1)-mediated apoptosis of neutrophils
13. Hydroxyl radical as a potential intracellular mediator of polymorphonuclear neutrophil apoptosis
14. Activation of the granule pool of the NADPH oxidase accelerates apoptosis in human neutrophils
15. Protein measurement with the folin phenol reagent
16. Neutrophil dysfunction and increased susceptibility to infection
17. Soluble Fas ligand is chemotactic for human neutrophilic polymorphonuclear leukocytes
18. A test of granulocyte membrane integrity and phagocytic function
19. Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil lead to its recognition by macrophages
20. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
21. Flow cytometric studies of oxidative product formation by neutrophils: A graded response to membrane stimulation
22. 2 inhibits apoptosis in human neutrophilic polymorphonuclear leukocytes: Role of intracellular cyclic AMP levels
23. Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent
24. 1- and Bax-α-mediated regulation of apoptosis of human neutrophils via caspase-3
25. Leukocyte-endothelial interactions and regulation of leukocyte migration
26. The adhesion molecules of inflammation
27. Neutrophil priming: Pathophysiological consequences and underlying mechanisms
28. Neutrophil apoptosis is modulated by endothelial transmigration and adhesion molecule engagement
29. Interleukin-8 delays spontaneous and tumor necrosis factor-α-mediated apoptosis of human neutrophils
30. Modulation of human neutrophil apoptosis by immune complexes
31. Modulation of neutrophil Fc and C3b receptors. Relationship with the phagocytic process and activation of the respiratory burst
32. Oxidative stress as a mediator of apoptosis
33. Hypoxia prolongs neutrophil survival in vitro
34. Red blood cells inhibit apoptosis of human neutrophils
35. Involvement of caspases in neutrophil apoptosis: Regulation by reactive oxygen species
36. Neutrophils undergo apoptosis following ingestion of Escherichia coli
37. Soluble and insoluble immune complexes activates human neutrophil NADPH oxidase by distinct Fcγ receptor-specific mechanisms
38. The glycosylphoshatidylinositol-linked Fcγ receptor represents the dominant receptor structure for immune complex activation of neutrophils
39. Role of oxygen radicals generated by NADPH oxidase in apoptosis induced in human leukemia cells
40. Apoptosis in resolution of inflammation