Hypothalamic 11,12-epoxyeicosatrienoic acid attenuates fever induced by central interleukin-1β in the rat

Neuroscience Letters

Volumn 310, Issue 2-3, 2001, Pages 141-144

  Nakashima, Toshihiro ^a   Yoshida, Yuka ^a   Miyata, Seiji ^a   Kiyohara, Toshikazu ^a  

^a KYOTO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Antipyretics; Arachidonic acid cascade; Cytochrome P 450; Epoxyeicosatrienoic acid; Fever; Hypothalamus

Indexed keywords

11,12 EPOXY 5,8,14 ICOSATRIENOIC ACID; ANTIPYRETIC AGENT; ARACHIDONIC ACID; CYTOCHROME P450; ENZYME; ICOSATRIENOIC ACID; INTERLEUKIN 1BETA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTERIOR HYPOTHALAMUS; ARTICLE; BODY TEMPERATURE; CONTROLLED STUDY; FEVER; ISOMER; MALE; METABOLITE; MOUSE; NONHUMAN; PREOPTIC AREA; PRIORITY JOURNAL; RAT;

8,11,14-EICOSATRIENOIC ACID; ANALGESICS, NON-NARCOTIC; ANIMALS; ANTERIOR HYPOTHALAMIC NUCLEUS; ARACHIDONIC ACID; CYTOCHROME P-450 ENZYME SYSTEM; FEVER; INTERLEUKIN-1; MALE; PREOPTIC AREA; RATS; RATS, WISTAR; VASODILATOR AGENTS;

EID: 0035860473     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(01)02115-2     Document Type: Article

References (11)

1. Cytochrome P-450 and the arachidonate cascade
2. 2 production in smooth muscle cells
3. Cytochrome P450 2C is an EDHF synthase in coronary arteries
4. Presence of sex difference of cytochrome P-450 in the rat preoptic area and hypothalamus with reference to coexistance with oxytocin
5. Inhibitors of alternative pathways of arachidonate metabolism differentially affect fever in mice
6. Role of cytochrome P-450 in endogenous antipyresis
7. 11,12-Epoxyeicosatrienoic acid stimulates endogenous mono-ADP-ribosylation in bovine coronary arterial smooth muscle
8. Inhibitors of cytochrome P-450 augment fever induced by interleukin-1β
9. Recombinant human interleukin-1β alters the activity of preoptic thermosensitive neurons in vitro
10. Cytokines and the nervous system II: Actions and mechanisms of action