Pronounced activity of enzymes through the incorporation into the core of polyion complex micelles made from charged block copolymers

Journal of Controlled Release

Volumn 72, Issue 1-3, 2001, Pages 85-91

  Harada, Atsushi ^a   Kataoka, Kazunori ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Block copolymer; Enzymatic reactor; Enzyme delivery; Poly(ethylene glycol); Polyion complex micelle

Indexed keywords

4 NITROPHENYL PENTA N ACETYL BETA CHITOPENTAOSIDE; BENZENE DERIVATIVE; COPOLYMER; EGG WHITE; LYSOZYME; POLY(ETHYLENE GLYCOL) POLY(ALPHA BETA ASPARTIC ACID)BLOCK; UNCLASSIFIED DRUG;

ANTIBODY DIRECTED ENZYME PRODRUG THERAPY; ARTICLE; CALORIMETRY; ENZYME ACTIVITY; ENZYME STABILITY; HYDROLYSIS; MICELLE; MICHAELIS CONSTANT; NONHUMAN; PRIORITY JOURNAL;

ALGORITHMS; ANTI-INFECTIVE AGENTS; CIRCULAR DICHROISM; DRUG COMPOUNDING; ENZYMES; EXCIPIENTS; KINETICS; MICELLES; MURAMIDASE; POLYMERS;

EID: 0035858376     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(01)00264-4     Document Type: Article

References (23)

1. Stability of protein pharmaceuticals
2. Parenteral formulations of proteins and peptides: Stability and stabilizers
3. Systematic delivery of therapeutic peptides and proteins
4. Delivery systems for biopharmaceuticals
5. Biodegradable polymers for proteins and peptides drug delivery
6. Advanced drug delivery reviews: Enzyme prodrug therapy
7. Antibody-directed enzyme prodrug therapy (ADEPT): A review
8. Relationship of effective molecular size to systemic clearance in rats of recombinant interleukin-2 chemically modified with water-soluble polymers
9. Immunogenicity of recombinant IL-2 modified by covalent attachment of polyethylene glycol
10. The uses and properties of PEG-linked proteins
11. Stabilization of L-asparaginase modified with comb-shaped poly(ethylene glycol) derivatives, in vivo and in vitro
12. Formation of polyion complex micelles in an aqueous milieu from a pair of oppositely charged block copolymers with poly(ethylene glycol) segments
13. Formation of stable and monodispersive polyion complex micelles in aqueous medium from poly(L-lysine) and poly(ethylene glycol)-poly(aspartic acid) block copolymer
14. Chain length recognition: Core-shell supramolecular assembly from oppositely charged block copolymers
15. Spontaneous formation of polyion complex micelles with narrow distribution from antisense oligonucleotide and cationic block copolymer in physiological saline
16. Water-soluble polyion complex associates of DNA and poly(ethylene glycol)-poly(L-lysine) block copolymer
17. Remarkable increase in nuclease resistance of plasmid DNA through supramolecular assembly with poly(ethylene glycol)-poly(L-lysine) block copolymer
18. Novel polyion complex micelles entrapping enzyme molecules in the core: Preparation of narrowly-distributed micelles from lysozyme and poly(ethylene glycol)-poly(aspartic acid) block copolymer in aqueous medium
19. On-off control of enzymatic activity synchronized with reversible formation of supramolecular assembly from enzyme and charged block copolymers
20. Lysozyme substrates. Chemical synthesis of p-nitrophenyl O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-(1→4)-O- (2-acetamido-2-deoxy-β-D-glucopyranosyl)-(1→4)- 2-acetamido-2-deoxy-β-D-glucopyranoside and its reaction with lysozyme
21. Distinguishing between possible mechanistic pathways during lysozyme-catalyzed cleavage of glycosidic bonds
22. Novel polyion complex micelles entrapping enzyme molecules in the core. 2. Characterization of the micelles prepared at nonstoichiometric mixing ratios