Insulin can enhance GLUT4 gene expression in 3T3-F442A cells and this effect is mimicked by vanadate but counteracted by cAMP and high glucose - Potential implications for insulin resistance

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1535, Issue 2, 2001, Pages 174-185

  Yu, Zhi Wen ^a,c   Burén, Jonas ^a   Enerbäck, Sven ^b   Nilsson, Ewa ^c   Samuelsson, Lena ^b   Eriksson, Jan W ^a  

^a UMEÅ UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

^c SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

8 BROMO CYCLIC AMP; BUTYRYL CYCLIC AMP; CELL PROTEIN; CYCLIC AMP; GLUCOSE; GLUCOSE TRANSPORTER; INSULIN; INSULIN RECEPTOR; IODINE 125; MESSENGER RNA; SIGNAL PEPTIDE; TRANSCRIPTION FACTOR; VANADIC ACID;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CELL CULTURE; CELL MEMBRANE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DOSE TIME EFFECT RELATION; GENE CONTROL; GENE EXPRESSION; GLUCOSE TRANSPORT; INSULIN BINDING; INSULIN RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN PHOSPHORYLATION; RAT; REGULATORY MECHANISM; TREATMENT OUTCOME;

3T3 CELLS; ADIPOCYTES; ANIMALS; BLOTTING, WESTERN; CULTURE MEDIA; CYCLIC AMP; DEOXYGLUCOSE; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; INSULIN; INSULIN RESISTANCE; MICE; MONOSACCHARIDE TRANSPORT PROTEINS; MUSCLE PROTEINS; PROTEIN-TYROSINE-PHOSPHATASE; RNA, MESSENGER; VANADATES;

EID: 0035857490     PISSN: 09254439     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4439(00)00097-1     Document Type: Article

References (51)

1. The glucose transporter family: Structure, function and tissue-specific expression
2. Potential mechanism of insulin action on glucose transport in the isolated rat adipose cells. Apparent translocation of intracellular transport systems to the plasma membrane
3. Evidence that insulin causes translocation of glucose transport activity to the plasma membrane from a cellular storage site
4. Insulin-regulated glucose uptake in rat adipocytes is mediated by two transporter isoforms present in at least two vesicle populations
5. Cell surface labeling of glucose transporter isoform GLUT4 by bis-mannose photolabel. Correlation with stimulation of glucose transport in rat adipose cells by insulin and porbol ester
6. Regulation of expression of glucose transporters by glucose: A review of studies in vivo and in cell cultures
7. Role of insulin resistance in human disease
8. Insulin resistance and the pathogenesis of non-insulin dependent diabetes mellitus: Cellular and molecular mechanisms
9. Differential regulation of two glucose transporters in adipose cells from diabetic and insulin-treated diabetic rats
10. Pretranslational suppression of a glucose transporter protein causes insulin resistance in adipocytes from patients with non-insulin-dependent diabetes mellitus and obesity
11. Insulin down-regulates expression of the insulin-responsive glucose transporter (GLUT4) gene: Effects on transcription and mRNA turnover
12. Differential regulation of GLUT-1 and GLUT-4 glucose transporter mRNA levels in 3T3-L1 adipocytes
13. Transcriptional repression of the mouse insulin-responsive glucose transporter (GLUT4) gene by cAMP
14. Differential regulation of the HepG2 and adipocyte/muscle glucose transporters in 3T3-L1 adipocytes. Effect of chronic glucose deprivation
15. Insulin-antagonistic effects of counterregulatory hormones: Clinical and mechanistic aspects
16. Insulin induces progressive insulin resistance in cultured rat adipocytes. Sequential effects at receptor and multiple postreceptor sites
17. Spontaneous heritable changes leading to increased adipose conversion in 3T3 cells
18. Regulation of adipocyte development
19. Insulin-mimetic effects of vanadate. Possible implications for future treatment of diabetes
20. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
21. Effect of glucose deprivation on GLUT1 expression in 3T3-L1 adipocytes
22. Regulation of glucose transporters in cultured rat adipocytes: Synergistic effect of insulin and dexamethasone on GLUT4 gene expression through promoter activation
23. Glucose-induced phosphorylation of the insulin receptor. Functional effects and characterization of phosphorylation sites
24. Hexosamines and insulin resistance
25. Normalization of blood glucose in diabetic rats with phlorizin treatment reverses insulin-resistant glucose transport in adipose cells without restoring glucose transporter gene expression
26. Cyclic AMP-induced transcriptional repression of the insulin-responsive transporter (GLUT4) gene: Identification of a promoter region required for down-regulation of transcription
27. Divergent regulation of the GLUT1 and GLUT4 glucose transporters in isolated adipocytes from Zucker rats
28. Insulin action, diabetogenes, and the cause of type II diabetes
29. Fat cell adrenergic receptors and the control of white and brown fat cell function
30. Phosphorylation of purified insulin receptor by cAMP kinase
31. Role of cytosolic tyrosine kinase in mediating insulin-like actions of vanadate in rat adipocytes
32. Inhibition of membrane phosphotyrosyl protein phosphatase activity by vanadate
33. Mechanism of inhibition of protein-tyrosine phosphatases by vanadate and pervanadate
34. Cryptic receptors for insulin-like growth factor II in the plasma membrane in rat adipocytes - A possible link to cellular insulin resistance
35. Vanadate augments insulin-stimulated insulin receptor kinase activity and prolongs insulin action in rat adipocytes. Evidence for transduction of amplitude of signaling into duration of response
36. Vanadate increases cell surface insulin binding and improves insulin sensitivity in both normal and insulin-resistant rat adipocytes
37. cAMP counter-regulates insulin-mediated protein phosphatase-2A inactivation in rat skeletal muscle cells
38. Vanadate activates membranous nonreceptor protein tyrosine kinase in rat adipocytes
39. Effects of media conditions, insulin, and dexamethasone on insulin-receptor mRNA and promoter activity in HepG2 cells
40. Hormonal regulation of insulin receptor gene expression: Hydrocortisone and insulin act by different mechanisms
41. Treatment of streptozotocin-induced diabetic rats with vanadate and phlorizin prevents the over-expression of the liver insulin receptor gene
42. Proximal enhancer of the human insulin receptor gene binds the transcription factor Sp1
43. Regulation of insulin receptors and insulin responsiveness in 3T3-L1 fatty fibroblasts
44. Regulation of insulin-stimulated glucose transport by chronic glucose exposure in 3T3-L1 adipocytes
45. Regulating insulin-receptor-gene expression by differentiation and hormones
46. Regulation of insulin receptor, insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-F442A adipocytes. Effects of differentiation, insulin, and dexamethasone
47. β-Adrenergic dependent downregulation of insulin binding in rat adipocytes
48. Cyclic AMP impairs the rapid effect of insulin to enhance cell-surface insulin-binding capacity in rat adipocytes
49. Glucose transport pivotal step in insulin action
50. Cell surface accessibility of GLUT4 glucose transporters in insulin-stimulated rat adipose cells. Modulation by isoprenaline and adenosine