Surface hydrophobicity of particles is not necessarily the most important determinant in their in vivo disposition after intravenous administration in rats

Journal of Controlled Release

Volumn 77, Issue 3, 2001, Pages 191-198

  Ogawara, Ken ichi ^a   Furumoto, Kentaro ^a   Takakura, Yoshinobu ^b   Hashida, Mitsuru ^b   Higaki, Kazutaka ^a   Kimura, Toshikiro ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Hepatic uptake; Pharmacokinetics; Polystyrene microsphere; Serum proteins; Surface hydrophobicity

Indexed keywords

BUFFER; MICROSPHERE; PHOSPHATIDYLCHOLINE; POLYSTYRENE;

ADSORPTION; ARTICLE; BINDING AFFINITY; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG STABILITY; DRUG TISSUE LEVEL; HYDROPHOBICITY; IN VIVO STUDY; LIVER; MALE; NONHUMAN; PARTICLE SIZE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; RAT; SYSTEMIC CIRCULATION; TISSUE DISTRIBUTION;

ANIMALS; BLOOD PROTEINS; HYDROPHOBICITY; INJECTIONS, INTRAVENOUS; MALE; MICROSPHERES; PARTICLE SIZE; PHOSPHATIDYLCHOLINES; POLYSTYRENES; RATS; RATS, WISTAR; SURFACE PROPERTIES; TISSUE DISTRIBUTION;

EID: 0035856811     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(01)00468-0     Document Type: Article

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