Identification of a Target Site in Plasminogen Activator Inhibitor-1 that Allows Neutralization of Its Inhibitory Properties Concomitant with an Allosteric Up-regulation of Its Antiadhesive Properties

Journal of Biological Chemistry

Volumn 276, Issue 28, 2001, Pages 26243-26248

  Ngo, Thu Hoa ^a   Hoylaerts, Marc F ^b   Knockaert, Isabelle ^a   Brouwers, Els ^a   Declerck, Paul J ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESIVES; BINDING ENERGY; CELL CULTURE; CHEMICAL ACTIVATION; CONFORMATIONS; ENZYME INHIBITION; MOLECULAR STRUCTURE; MONOCLONAL ANTIBODIES; REDUCTION;

BINDING PROPERTIES;

BIOCHEMISTRY;

IMMUNOGLOBULIN F(AB) FRAGMENT; MONOCLONAL ANTIBODY; PLASMINOGEN ACTIVATOR INHIBITOR 1; SERINE PROTEINASE INHIBITOR; VITRONECTIN; ANTIBODY;

ALLOSTERISM; ANIMAL CELL; ARTICLE; CELL ADHESION; CELL MIGRATION; CONTROLLED STUDY; ENZYME ACTIVE SITE; MALE; METASTASIS; MUTATION; NONHUMAN; PLASMINOGEN ACTIVATION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RAT; THERMOSTABILITY; ANIMAL; CHEMISTRY; EPITOPE MAPPING; HUMAN; IMMUNOLOGY; METABOLISM; PROTEIN BINDING; PROTEIN CONFORMATION; UPREGULATION;

ANIMALIA;

ALLOSTERIC REGULATION; ANIMALS; ANTIBODIES; EPITOPE MAPPING; HUMANS; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN BINDING; PROTEIN CONFORMATION; RATS; UP-REGULATION; VITRONECTIN;

EID: 0035854722     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M008241200     Document Type: Article

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