Thrombin, thrombomodulin, and extracellular signal-regulated kinases regulating cellular proliferation

Circulation Research

Volumn 88, Issue 7, 2001, Pages 651-653

  Freedman, J E ^a  

^a GEORGETOWN UNIVERSITY   (United States)

Author keywords

Mitogen activated protein kinase; Thrombin; Thrombomodulin

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; THROMBIN; THROMBOMODULIN;

CELL CYCLE; CELL PROLIFERATION; EDITORIAL; ENDOTHELIUM CELL; ENZYME ACTIVITY; HEMOSTASIS; HUMAN; INTRACELLULAR TRANSPORT; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; THROMBOSIS;

EID: 0035853413     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/hh0701.089956     Document Type: Editorial

References (15)

1. Thrombin and vascular smooth muscle cell proliferation: Implications for atherosclerosis and restenosis
2. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
3. How the protease thrombin talks to cells
4. Thrombomodulin: A linker of coagulation and fibrinolysis and predictor of risk of arterial thrombosis
5. Surface thrombomodulin modulates thrombin receptor responses on vascular smooth muscle cells
6. Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-related kinase activation
7. Growth factor-induced p42/p44 MAPK nuclear translocation and retention requires both MAPK activation and neosynthesis of nuclear anchoring proteins
8. Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase
9. Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry
10. Thrombomodulin prolongs thrombin-induced extracellular signal-regulated kinase phosphorylation and nuclear retention in endothelial cells
11. Protease-activated receptor-1 can mediate responses to SFLLRN in thrombin-desensitized cells: Evidence for a novel mechanism for preventing or terminating signaling by PAR1's tethered ligand
12. Significance of nuclear relocalization of ERK 1/2 in reactivation of c-fos transcription and DNA synthesis in senescent fibroblasts
13. Expression of thrombomodulin in atherosclerotic lesions and mitogenic activity of recombinant thrombomodulin in vascular smooth muscle cells
14. Recombinant thrombomodulin inhibits arterial smooth muscle cell proliferation induced by thrombin
15. Different effects of thrombin receptor activation on endothelium and smooth muscle cells of human coronary bypass vessels: Implications for venous bypass graft failure