Immunization with plasmid DNA encoding MHC class II binding peptide/CLIP-replaced invariant chain (Ii) induces specific helper T cells in vivo: The assessment of Ii p31 and p41 isoforms as vehicles for immunization

Vaccine

Volumn 20, Issue 1-2, 2001, Pages 105-114

  Nagata, Toshi ^a   Higashi, Takahide ^a   Aoshi, Taiki ^a   Suzuki, Mina ^a   Uchijima, Masato ^a   Koide, Yukio ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

DNA immunization; Invariant chain; Th epitope

Indexed keywords

ANTIBODY; EPITOPE; GAMMA INTERFERON; ISOENZYME; MAJOR HISTOCOMPATIBILITY ANTIGEN; PLASMID DNA; PROTEIN P31; PROTEIN P41; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE GUN; GENETIC CODE; HELPER CELL; IMMUNIZATION; IN VIVO STUDY; INFECTION PREVENTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; SPLEEN CELL; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; BASE SEQUENCE; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; HISTOCOMPATIBILITY ANTIGENS CLASS II; INTERFERON TYPE II; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; OVALBUMIN; PEPTIDE FRAGMENTS; PLASMIDS; PROTEIN ISOFORMS; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES, HELPER-INDUCER; TRANSFECTION; VACCINATION; VACCINES, DNA;

EID: 0035850990     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(01)00310-3     Document Type: Article

References (32)

1. DNA vaccines
2. DNA vaccines: A review
3. DNA immunization targeting the skin: Molecular control of adaptive immunity
4. Optimization of codon usage of plasmid DNA vaccine is required for the effective MHC class I-restricted T cell responses against an intracellular bacterium
5. Codon optimization effect on translational efficiency of DNA vaccine in mammalian cells: Analysis of plasmid DNA encoding a CTL epitope derived from microorganisms
6. Immunity to intracellular bacteria
7. + T lymphocytes in atopic patients
8. Allergen- and bacterial antigen-specific T-cell clones established from atopic donors show a different profile of cytokine production
9. Organ-specific autoimmunity
10. Get into the groove! Targeting antigens to MHC class II
11. Efficient loading of HLA-DR with a T helper epitope by genetic exchange of CLIP
12. MHC class II-associated invariant chain peptide replacement by T cell epitopes: Engineered invariant chain as a vehicle for directed and enhanced MHC class II antigen processing and presentation
13. The CLIP- substituted invariant chain efficiently targets an antigenic peptide to HLA class II pathway in L cells
14. MHC class II antigen processing: Biology of invariant chain
15. Antigen processing and presentation
16. + T cells after gene gun immunization
17. DNA-based immunization by in vivo transfection of dendritic cells
18. lo thymocytes in vivo
19. The major histocompatibility complex-restricted antigen receptor on T cells I. Isolation with a monoclonal antibody
20. Advantage of gene gun-mediated over intramuscular inoculation of plasmid DNA vaccine in reproducible induction of specific immune responses
21. Requirements for the processing of antigens by antigen-presenting B cells I. Functional comparison of B cell tumors and macrophages
22. Shared idiptopes between anti-class II monoclonal antibodies and major histocompatibility complex recognition site of T cells
23. Dissection of strain difference in acquired protective immunity against Mycobacterium bovis Calmette-Guérin Bacillus (BCG)
24. One gene encodes two distinct Ia-associated inavariant chains
25. d
26. Evidence for invariant chain 85-101 (CLIP) binding in the antigen binding site of MHC class II molecules
27. The proteolytic environment involved in MHC class II-restricted antigen presentation can be modulated by the p41 form of invariant chain
28. Major histocompatibility complex class II-associated p41 invariant chain fragment is a strong inhibitor of lysosomal cathepsin L
29. Antigen presentation enhanced by the alternatively spliced invariant chain gene product p41
30. Relationship between invariant chain expression and major histocompatibility complex class II transport into early and late endocytic compartments
31. Rapid intracellular pathway gives rise to cell surface expression of the MHC class II associated invariant chain (CD74)
32. Cell surface HLA-DR-invariant chain complexes are targeted to endosomes by rapid internalization