Riluzole (2-amino-6-trifluoromethoxy benzothiazole) attenuates MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxicity in mice

Neuroscience Letters

Volumn 312, Issue 1, 2001, Pages 50-54

  Araki, Tsutomu ^a   Muramatsu, Yasuko ^a   Tanaka, Katsuyuki ^a   Matsubara, Mitsunobu ^a   Imai, Yutaka ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

1 methyl 4 phenyl 1,2,3,6 tetrahydropyridine; 2 amino 6 trifluoromethoxy benzothiazole; Dopamine; Immunohistochemistry; Mice; MK 801; Parkinson's disease; Striatum

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; 3,4 DIHYDROXYPHENYLACETIC ACID; DIZOCILPINE; DOPAMINE; GLIAL FIBRILLARY ACIDIC PROTEIN; HOMOVANILLIC ACID; MICROTUBULE ASSOCIATED PROTEIN 2; RILUZOLE; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT; TYROSINE 3 MONOOXYGENASE;

ARTICLE; ASTROCYTE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORPUS STRIATUM; DISEASE COURSE; DOPAMINERGIC NERVE CELL; DRUG EFFECT; IMMUNOHISTOCHEMISTRY; MOUSE; NERVE CELL LESION; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; STRIATONIGRAL DEGENERATION; SUBSTANTIA NIGRA; TARGET CELL;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; 3,4-DIHYDROXYPHENYLACETIC ACID; ANIMALS; ASTROCYTES; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; DRUG INTERACTIONS; EXCITATORY AMINO ACID ANTAGONISTS; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTAMIC ACID; HOMOVANILLIC ACID; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED C57BL; MICROTUBULE-ASSOCIATED PROTEINS; NEOSTRIATUM; NEURONS; NEUROPROTECTIVE AGENTS; PARKINSONIAN DISORDERS; RILUZOLE; SUBSTANTIA NIGRA; TYROSINE 3-MONOOXYGENASE;

EID: 0035850963     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(01)02176-0     Document Type: Article

References (15)

1. Biochemical and immunohistological changes in the brain of 1-methyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice
2. Neuroprotective effects of riluzole on a model of Parkinson's disease in the rat
3. 2-Amino-6-trifluoromethoxy benzothiazole, a possible antagonist of excitatory amino acid neurotransmission II. Biochemical properties
4. Riluzole prevents MPTP-induced parkinsonism in the rhesus monkey: A preliminary study
5. The ALS/Riluzole Study Group, a controlled trial of riluzole in amyotrophic lateral sclerosis
6. Riluzole delayed appearance of parkinsonian motor abnormalities in a chronic MPTP monkey model
7. +-induced increase in striatal extracellular dopamine in rats in vivo
8. Riluzole and experimental parkinsonism: Antagonism of MPTP-induced decrease in central dopamine levels in mice
9. Synthesis of the antioxidant glutathione in neurons: Supply by astrocytes of CysGly as precursor for neuronal glutathione
10. The novel anticonvulsant lamotrigine prevents dopamine depletion in C57 black mice in the MPTP animal model of Parkinson's disease
11. High susceptibility to cerebral ischemia in GFAP-null mice
12. Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine
13. Differential vulnerability of dopamine receptors in the mouse brain treated by MPTP
14. Protection of substantia nigra from MPP+ neurotoxicity by N-methyl-D-aspartate antagonists
15. Astrocytes provide cysteine to neurons by releasing glutathione