Human chorionic gonadotropin β-core fragment is directly produced by cancer cells

Life Sciences

Volumn 68, Issue 8, 2001, Pages 861-872

  Okamoto, Tomomitsu ^a   Niu, Rong ^b   Matsuo, Katsuhiko ^c   Furuhashi, Madoka ^d   Ohsawa, Masami ^a   Mizutani, Shigehiko ^b   Suzuki, Hideo ^c  

^a CHUKYO HOSPITAL   (Japan)

^b NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c Base Technology Center   (Japan)

^d Handa City Hospital   (Japan)

Author keywords

Cancer; hCG core fragment

Indexed keywords

CHORIONIC GONADOTROPIN BETA SUBUNIT;

ARTICLE; CANCER CELL CULTURE; CHO CELL; CHORIOCARCINOMA; HALF LIFE TIME; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; NUDE MOUSE; OVARY CANCER; PROTEIN LOCALIZATION;

CRICETINAE; CRICETULUS GRISEUS;

EID: 0035846887     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(00)00986-3     Document Type: Article

References (35)

1. Detection of the free beta subunit of human chorionic gonado-tropin in cultures of normal and malignant trophoblast cells, pregnancy sera, and sera of patients with chorio-carcinoma
2. Human chorionic gonadotropin (hCG) and its free subunits in hydrocele fluids and neoplastic tissue of testicular cancer patients: Insights into thein vivo hCG secretion pattern
3. Free human chorionic gonadotropinb subunit in gonadal and nongonadal neoplasms
4. Detection ofb-human chorionic gonadotropin mRNA as a marker for cutaneous malignant melanoma
5. Expression ofa andb genes of human chorionic gonadotropin in lung cancer
6. Elevation of freeb subunit of human choriogonadotropin and coreb fragment of human choriogonadotropin in the serum and urine of patients with malignant pancreatic and biliary disease
7. Assessment of urinary b-core fragment of human chorionic gonadotropin as a new tumor marker of lung cancer
8. Structure of the human chorionic gonadotropin b-subunit fragment from pregnancy urine
9. Purification ofb-core fragment from pregnancy urine and demonstration that its carbohydrate moieties differ from those of native human chorionic gonadotropin-b
10. The origin of a human chorionic gonadotropin beta-subunit-core fragment excreted in the urine of patients with cancer
11. Beta core fragment (b-core/UGF/UGP) a tumor marker: A 7-year report
12. Characterization of a discrete degradation product of the human chorionic gona-dotropinb-subunit in humans
13. Evidence that desialylation and uptake by hepatic receptors for galactose-terminated glycoproteins are immaterial to the metabolism of human choriogonadotropin in the rat
14. Renal metabolism of theb-subunit of human choriogonadotropin in the rat
15. Origin and occurrence of human chorionic gonadotropinb-subunit core fragment
16. Human chorionic gonadotropinb-core fragment is present in the human placenta
17. Establishment of a human ovarian cancer cell line capable of forming ascites in nude mice and effects of tranexamic acid on cell proliferation and ascites formation
18. Establishment and characterization of three new human gestational choriocarcinoma cell lines
19. Serological analysis of cell surface antigens in choriocarci-noma cell lines
20. A newly synthesized bifunctional inhibitor, W-77, enhances adriamycin activity against human ovarian carcinoma cells
21. Mutagenesis of cysteine residues in the human gonadotropina subunit
22. Development and characterization of a new, highly specific antibody to the human chorionic gonadotropin-b fragment
23. Urinary concentrations of beta core fragment of hCG throughout pregnancy
24. Metabolic clearance rate and urinary clearance of purified b-core
25. Disparity between b-core levels in pregnancy urine and serum: Implications for the origin of urinary β-core
26. In vitro secretion of human chorionic gonadotrophin by bladder tumour cells
27. Chorionic gonadotropin synthesis by human tumor cell lines: Examination of subunit accumulation, steady-state levels of mRNA, and gene structure
28. Expression of beta human chorionic go-nadotrophin by non-trophoblastic non-endocrine 'normal' and malignant epithelial cells
29. Human chorionic gonadotropin-beta subunit gene expression in cultured human fetal and cancer cells of different types and origins
30. Urinary gonadotrophin peptide-isolation and purification, and its immunohistochemical distribution in normal and neoplastic tissues
31. The purification and development of a radioimmunoas-say forb-core fragment of human chorionic gonadotrophin in urine: Application as a marker of gynaecologi-cal cancer in premenopausal and postmenopausal women
32. Urinary screening tests for fetal Down syndrome: I. Freshb-core fragment
33. A distinctive form of human chorionic gonadotropinb-subunit-like material produced by cervical carcinoma cells
34. Serum hCGb-core fragment is masked by associated macromolecules
35. Differential production of human chorionic gona-dotropin and free subunits in gestational trophoblastic disease