Decrease of N-acetylaspartate in the MTL correlates with cognitive decline of AD patients

Neurology

Volumn 57, Issue 5, 2001, Pages 930-932

  Jessen, Frank ^a   Block, W ^a   Traber F ^a   Keller, E ^a   Flacke, S ^a   Lamerichs, R ^b   Schild, H H ^a   Heun, R ^a  

^a UNIVERSITY OF BONN   (Germany)

^b PHILIPS HEALTHCARE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CREATINE; N ACETYLASPARTIC ACID;

ADULT; AGED; ALZHEIMER DISEASE; AMINO ACID BRAIN LEVEL; ARTICLE; CLINICAL ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; CORRELATION FUNCTION; DETERIORATION; FEMALE; HUMAN; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; TEMPORAL LOBE;

EID: 0035845620     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/WNL.57.5.930     Document Type: Article

References (7)

1. N-acetylaspartate in neuropsychiatric disorders
2. Proton MR spectroscopy detects a relative decrease of N-acetylaspartate in the medial temporal lobe of patients with AD
3. Neuropathological staging of Alzheimer-related changes
4. Changes of hippocampal N-acetylaspartate and volume in Alzheimer's disease. A proton MR spectroscopic imaging and MRI study
5. In vivo brain concentrations of N-acetyl compounds, creatine, and choline in Alzheimer disease
6. Longitudinal decline of the neuronal marker N-acetyl aspartate in Alzheimer's disease
7. 1H MRS study of probable Alzheimer's disease and normal aging: Implications for longitudinal monitoring of dementia progression