Prolonged circulation time of doxorubicin-loaded liposomes coated with a modified polyvinyl alcohol after intravenous injection in rats

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 48, Issue 2, 1999, Pages 123-129

  Takeuchi, Hirofumi ^a   Kojima, Hiroyuki ^a   Toyoda, Toshitada ^a   Yamamoto, Hiromitsu ^a   Hino, Tomoaki ^a   Kawashima, Yoshiaki ^a  

^a GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Doxorubicin; Liposomes; Modified polyvinyl alcohol; Polymer coating; Reticuloendothelial system avoidance

Indexed keywords

CHOLESTEROL; DOXORUBICIN; LIPOSOME; PHOSPHATIDYLCHOLINE; POLYVINYL ALCOHOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CIRCULATION TIME; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG COATING; DRUG DISTRIBUTION; DRUG MONITORING; ENCAPSULATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; PARTICLE SIZE; RAT;

ANIMALS; ANTINEOPLASTIC AGENTS; COATED MATERIALS, BIOCOMPATIBLE; DOXORUBICIN; DRUG CARRIERS; INJECTIONS, INTRAVENOUS; LIPOSOMES; MALE; POLYVINYL ALCOHOL; RATS; RATS, WISTAR; RETICULOENDOTHELIAL SYSTEM; TISSUE DISTRIBUTION;

EID: 0032799277     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0939-6411(99)00029-6     Document Type: Article

References (17)

1. Poste G., Bucana C., Raz A., Bugelski P., Kirsh R., Fidler I.J. Analysis of the fate of systemically administered liposomes and implications for their use in drug delivery. Cancer Res. 42:1982;1412-1422.
2. Senior J.H. Fate and behavior of liposomes in vivo: a review of controlling factors. Crit. Rev. Ther. Drug Carrier Syst. 3:1987;123-193.
3. Mayer L.D., Tai L.C.L., Ko D.S.C., Masin D., Ginsberg R.S., Cullis P.R., Bally M.B. Influence of vesicle size, lipid composition, and drug-to-lipid ratio on the biological activity of liposomal doxorubicin in mice. Cancer Res. 49:1989;5922-5930.
4. Storm G., Roerdink F.H., Steerenberg P.A., de Jong W.H., Crommelin D.J.A. Influence of lipid composition on antitumor activity exerted by doxorubicin-containing liposomes in a rat solid tumor model. Cancer Res. 47:1987;3366-3372.
5. Allen T.M., Chonn A. Large unilamellar liposomes with low uptake into the reticuloendothelial system. FEBS Lett. 223:1987;42-46.
6. Allen T.M., Hansen C., Rutledge J. Liposomes with prolonged circulation times: factors affecting uptake by reticuloendothelial and other tissues. Biochim. Biophys. Acta. 981:1989;27-35.
7. Allen T.M., Hansen C., Martin F., Redemann C., Yau-Young A. Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo. Biochim. Biophys. Acta. 1066:1991;29-36.
8. Papahadjopoulos D., Allen T.M., Gabizon A., Mayhew E., Matthay K., Huang S.K., Lee K.D., Woodle M.C., Lasic D.D., Redemann C., Martin F.J. Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy. Proc. Natl. Acad. Sci. USA. 88:1991;11460-11464.
9. Namba Y., Sakakibara T., Masada M., Ito F., Oku N. Glucuronate-modified liposomes with prolonged circulation time. Chem. Pharm. Bull. 38:1990;1663-1666.
10. Senior J., Delgado C., Fisher D., Tilcock C., Gregoriadis G. Influence of surface hydrophilicity of liposomes on their interaction with plasma protein and clearance from the circulation: studies with poly(ethylene glycol)-coated vesicles. Biochim. Biophys. Acta. 1062:1991;77-82.
11. Takeuchi H., Yamamoto H., Hino T., Kawashima Y. Mucoadhesion of polymer-coated liposomes to rat intestine in vitro. Chem. Pharm. Bull. 42:1994;1954-1956.
12. Takeuchi H., Yamamoto H., Toyoda T., Toyobuku H., Hino T., Kawashima Y. Physical stability of size controlled small unilamellar liposomes coated with a modified polyvinyl alcohol. Int. J. Pharm. 164:1998;103-111.
13. Mayer L.D., Bally M.B., Cullis P.R. Uptake of Adriamycin into large unilamellar vesicles in response to a pH gradient. Biochim. Biophys. Acta. 857:1986;123-126.
14. Masuike T., Odake J., Kohagura M., Noda T., Takemoto Y. Determination of Adriamycin and its metabolites in biological samples using high performance liquid chromatography II. Analysis of tissues by extraction method (in Japanese). Yakugaku Zasshi. 104:1984;620-623.
15. Woodle M.C., Lasic D.D. Sterically stabilized liposomes. Biochim. Biophys. Acta. 1113:1992;171-199.
16. Rahman A., Kessler A., More N., Sikic B., Rowden G., Woolley P., Schein P.S. Liposomal protection of Adriamycin-induced cardiotoxicity in mice. Cancer Res. 40:1980;1532-1537.
17. Gabizon A., Dagan A., Goren D., Barenholz Y., Fuks Z. Liposomes as in vivo carriers of Adriamycin: reduced cardiac uptake and preserved antitumor activity in mice. Cancer Res. 42:1982;4734-4739.