Autoradiographic studies using L-[14C]DOPA and L-[3H]DOPA reveal regional Na+-dependent uptake of the neurotransmitter candidate L-DOPA in the CNS

Neuroscience

Volumn 104, Issue 1, 2001, Pages 1-14

  Sugaya, Y ^a,c   Sasaki, Y ^a   Goshima, Y ^a   Kitahama, K ^b   Kusakabe, T ^a   Miyamae, T ^a   Kato, T ^c   Misu, Y ^a  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

^b INSERM   (France)

^c YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

Autoradiography; L DOPA; Neurotransmitter; Rat brain slice; Transporter; Uptake

Indexed keywords

DOPAMINE; LEVODOPA; NEUROTRANSMITTER UPTAKE INHIBITOR; PHENYLALANINE; SODIUM ION;

AMINO ACID TRANSPORT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BRAIN NERVE CELL; BRAIN REGION; BRAIN SLICE; CENTRAL NERVOUS SYSTEM; CHOROID PLEXUS; CONTROLLED STUDY; DOPAMINE BRAIN LEVEL; DOPAMINE RELEASE; EPENDYMA CELL; GLIA CELL; IMMUNOREACTIVITY; MALE; NEUROMODULATION; NEUROTRANSMITTER UPTAKE; NONHUMAN; PRIORITY JOURNAL; PURKINJE CELL; RAT;

ANIMALS; AUTORADIOGRAPHY; CARBON RADIOISOTOPES; CENTRAL NERVOUS SYSTEM; IMMUNOHISTOCHEMISTRY; LEVODOPA; MALE; NEUROGLIA; NEURONS; NEUROTRANSMITTER AGENTS; RATS; RATS, WISTAR; SODIUM; TRITIUM;

EID: 0035836468     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(01)00008-2     Document Type: Article

References (48)

1. Inhibitory effects of L-3,4-dihydoxyphenylalanine (L-dopa) on neuronal activities in the hippocampal CA1 in vitro
2. Immunohistochemical evidence that central serotonin neurons produce dopamine from exogenous L-DOPA in the rat, with reference to the involvement of aromatic L-amino acid decarboxylase
3. Co-expression of dopamine transporter mRNA and tyrosine hydroxylase mRNA in ventral mesencephalic neurones
4. Transient expression of tyrosine hydroxylase immunoreactivity in some neurons of the rat neocortex during postnatal development
5. FluoroDOPA PET shows the nondopaminergic as well as dopaminergic destinations of levodopa
6. Dopamine transporter mRNA expression is intense in rat midbrain neurons and modest outside midbrain
7. Identification of an amino acid transporter associated with the cystinuria-related type II membrane glycoprotein
8. The dopamine transporter; immunochemical characterization and localization in brain
9. 3H]DOPA in the telencephalon of the living rat
10. Transporters for cationic amino acids in animal cells: Discovery, structure, and function
11. o,+AT) of rBAT
12. Dopamine transporter immunoreactivity in rat brain
13. L-DOPA cyclohexyl ester is a novel potent and relatively stable competitive antagonist against L-DOPA among several L-DOPA ester compounds
14. Characterization of transport systems for the transfer of 3,4-L-dihydroxyphenylalanine into slices of rat cerebral cortex
15. Tyrosine hydroxylase-immunoreactive neurons in the human cerebral cortex: A novel catecholaminergic group?
16. Transmitter-like release of endogenous 3,4-dihydroxyphenylalanine from rat striatal slices
17. 2-adrenoceptors under essentially complete inhibition of L-aromatic amino acid decarboxylase in rat hypothalamic slices
18. L-Dihydroxyphenylalnine methyl ester is a potent competitive antagonist of the L-dihydroxyphenylalanine-induced facilitation of the evoked release of endogenous norepinephrine from rat hypothalamic slices
19. Picomolar concentrations of L-DOPA stereoselectively potentiate activities of presynaptic β-adrenoceptors to facilitate the release of endogenous noradrenaline from rat hypothalamic slices
20. 2+-dependent and tetrodotoxin-sensitive release of endogenous glutamate from rat striatal slices
21. + RNA
22. Aromatic L-amino acid decarboxylase in the rat brain: Immunocytochemical localization in neurons of the brain stem
23. Production of specific antibody against L-DOPA and its ultrastructual localization of immunoreactivity in the house-shrew (Suncus murinus) lateral habenular nucleus
24. Endogenous L-DOPA, its immunoreactivity in neurons of midbrain and its projection fields in the cat
25. The tuberoinfundibular system of the rat as demonstrated by immunohistochemical localization of retrogradely transported wheat germ agglutinin (WGA) from the median eminence
26. The distribution of tyrosine hydroxylase-immunoreactive fibers in primate neocortex is widespread but regionally specific
27. Cell-type-specific expression of catecholamine transporters in the rat brain
28. Aminobutyric acid is a neuromodulator in sinus node of guinea-pig heart
29. Regulatory and molecular aspects of mammalian amino acid transport
30. 3H]L-DOPA in rats
31. Immunocytochemical localization of growth hormone-releasing factor in the rat hypothalamus
32. Is L-DOPA an endogenous neurotransmitter?
33. Neurobiology of L-DOPAergic systems
34. L-DOPAergic components in the caudal ventrolateral medulla in baroreflex neurotransmission
35. Specific antisera against the catecholamines; L-3,4-dihydroxyphenylalanine, dopamine, noradrenaline and octopamine tested by an enzyme-linked immunosorbent assay
36. +-evoked release of 3,4-dihydroxyphenylalanine from the striatum in conscious rats studied by microdialysis
37. An L-DOPAergic relay from the posterior hypothalamic nucleus to the rostral ventrolateral medulla and its cardiovascular function in anesthetized rats
38. L-dopa-immunoreactive neurons in the rat hypothalamic tuberal region
39. Coexistence of growth hormone releasing factor-like and tyrosine hydroxylase-like immunoreactivities in neurons of the rat arcuate nucleus
40. Kinetics and Na independence of amino acid uptake by blood side of perfused sheep choroid plexus
41. Glutamate transporter GLAST is expressed in the radial glia-astrocyte lineage of developing mouse spinal cord
42. Dopamine transporter mRNA: Dense expression in ventral midbrain neurons
43. 3H]DOPA uptake sites in rat brain - Microautoradiographic study
44. Endogenous L-DOPA in the rat dorsal vagal complex: An immunocytochemical study by light and electron microscopy
45. Characterization of L-DOPA transport in cultured rat and mouse astrocytes
46. Cells of origin of the afferent fibers to the median eminence in the rat
47. Baroreceptor-aortic nerve-mediated release of endogenous L-3,4-dihydroxyphenylalanine and its tonic depressor function in the nucleus tractus solitarii of rats
48. The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier