Crosslinking CD81 results in activation of TCRγδ T cells

Cellular Immunology

Volumn 207, Issue 1, 2001, Pages 19-27

  Tseng, Chien Te K ^a   Miskovsky, Emil ^b   Klimpel, Gary R ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

Cytokine; IFN ; T cell activation; T cells

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CD81 ANTIGEN; CYTOKINE; INTERLEUKIN 2; T LYMPHOCYTE RECEPTOR DELTA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN;

ARTICLE; CONTROLLED STUDY; CROSS LINKING; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

EID: 0035834913     PISSN: 00088749     EISSN: None     Source Type: Journal    
DOI: 10.1006/cimm.2000.1744     Document Type: Article

References (45)

1. CD81 (TAPA-1): A molecule involved in signal transduction and cell adhesion in the immune system
2. The ins and outs of the transmembrane 4 superfamily
3. Selective tetraspan-integrin complexes (CD81/α4β1, CD151/α3β1, CD151/α6β1) under conditions disrupting tetraspan interactions
4. CD9 antigen is an accessory subunit of the VLA integrin complexes
5. Specifc association of CD63 with the VLA-3 and VLA-6 integrins
6. CD9, CD63, CD81, and CD82 are components of a surface tetraspan network connected to HLA-DR and VLA integrins
7. Characterization of novel complexes on the cell surface between integrins and proteins with 4 transmembrane domains (TM4 proteins)
8. Transmembrane-4 superfamily proteins CD81 (TAPA-1), CD82, CD63, and CD53 specifically associated with integrin alpha 4 beta 1 (CD49d/CD29)
9. CD63 associates with transmembrane 4 superfamily members, CD9, and CD81, and with beta 1 integrins in human melanoma
10. Association of four antigens of the tetraspan family (CD37, CD53, TAPA-1, and R2/C33) with MHC class II glycoproteins
11. CD19 is linked to the integrin-associated tetraspans CD9, CD81, and CD82
12. The CD19/CR2/TAPA-1 complex of B lymphocytes
13. Association of TM4SF proteins with integrins: Relevance to cancer
14. The tetraspanin superfamily: Molecular facilitators
15. The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules
16. The CD19/CD21 signal transduction complex on B lymphocytes
17. CD19: Lowering the threshold for antigen receptor stimulation of B lymphocytes
18. Engaging CD19 or target of antiproliferative antibody-1 on human B lymphocytes induces binding of B cells to the interfollicular stroma of human tonsils via integrin alpha 4/beta 1 and fibronectin
19. CD81 on B cells promotes interleukin 4 secretion and production during T helper type 2 immune responses
20. Ligation of TAPA-1 (CD81) or major histocompatibility complex class II in co-cultures of human B and T lymphocytes enhances interleukin-4 synthesis by antigen-specific T cells
21. Molecular analyses of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82
22. C33 antigen and M38 antigen recognized by monoclonal antibodies inhibitory to syncytium formation by human T cell leukemia virus type I are both members of the transmembrane 4 superfamily and associate with each other and with CD4 or CD8 in T cells
23. CD81 expressed on human thymocytes mediates integrin activation and interleukin-2-dependent proliferation
24. The 4F9 antigen is a member of the tetra spans transmembrane protein family and functions as an accessory molecule in T cell activation and adhesion
25. CD82, member of the tetra-span-transmembrane protein family, is a costimulatory protein for T cell activation
26. Functional analysis of CD82 in the early phase of T cell activation: Roles in cell adhesion and signal transduction
27. Human T cell recognition of Listeria monocytogenes: Recognition of listeriolysin O by TCRαβ and TCRγδ T cells
28. Dynamics of intra-hepatic lymphocytes in chronic hepatitis C: Enrichment for Va24+ T cells and rapid elimination of effector cells by apoptosis
29. Distribution and heterogeneity of liver-infiltrating CD56-positive T lymphocytes in chronic hepatitis related to hepatitis C viral infection
30. Life, activation and death of intrahepatic lymphocytes in chronic hepatitis C
31. -) T cells with an α/β T-cell receptor: Non MHC-restricted cytotoxic activity and lymphokine production
32. Anti-TAPA-1 antibodies induce protein tyrosine phosphorylation that is prevented by increasing intracellular thiol levels
33. + T cells by the interaction of VLA-4 and VLA-5 with fibronectin or VLA-6 with laminin
34. Fibronectin promotes proliferation of naive and memory T cells by signaling through both the VLA-4 and VLA-5 integrin molecules
35. Activation of human CD4 T lymphocytes. Interaction of fibronectin with VLA-5 receptor on CD4 cells induces the AP-1 transcription factor
36. Adhesion and costimulation of proliferative responses of human gamma delta T cells by interaction of VLA-4 and VLA-5 with fibronectin
37. Stimulation of T cells via CD44 requires leukocyte-function-associated antigen interactions and interleukin-2 production
38. A VLA-4 alpha-chain specific monoclonal antibody enhances CD3-induced IL-2/IL-2 receptor-dependent T-cell proliferation
39. Integrins: Emerging paradigms of signal transduction
40. Signal transduction through integrins: A central role for focal adhesion kinase
41. Integrins and signal transduction pathways: The road taken
42. A novel link between integrins, transmembrane-4 superfamily proteins (CD63 and CD81), and phosphatidylinositol 4-kinase
43. Functional analysis of cell surface-expressed hepatitis C virus E2 glycoprotein
44. Characterization of hepatitis C virus E2 glycoprotein interaction with a putative cellular receptor, CD81
45. Binding of hepatitis C virus to CD81