Functional analysis of cell surface-expressed hepatitis C virus E2 glycoprotein

Journal of Virology

Volumn 73, Issue 8, 1999, Pages 6782-6790

  Flint, Mike ^a   Thomas, Joanne M ^a   Maidens, Catherine M ^a   Shotton, Christine ^b   Levy, Shoshana ^c   Barclay, Wendy S ^a   Mckeating, Jane A ^a  

^a UNIVERSITY OF READING   (United Kingdom)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^c STANFORD UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CD81 ANTIGEN; GLYCOPROTEIN; HEMAGGLUTININ; MONOCLONAL ANTIBODY;

ARTICLE; CELL FUSION; CELL SURFACE; FLOW CYTOMETRY; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; INFLUENZA VIRUS A; PH; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0032813509     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.8.6782-6790.1999     Document Type: Article

References (53)

1. Andria, M. L., and S. Levy. Unpublished results.
2. Choukhi, A., S. Ung, C. Wychowski, and J. Dubuisson. 1998. Involvement of endoplasmic reticulum chaperones in the folding of hepatitis C virus glycoproteins. J. Virol. 72:3851-3858.
3. Chu, G., H. Hayakawa, and P. Berg. 1987. Electroporation for the efficient transfection of mammalian cells with DNA. Nucleic Acids Res. 15:1311-1326.
4. Clarke, B. 1997. Molecular virology of hepatitis C virus. J. Gen. Virol. 78:2397-2410.
5. Cocquerel, L., J.-C. Meunier, A. Pillez, C. Wychowski, and J. Dubuisson. 1998. A retention signal necessary and sufficient for endoplasmic reticulum localization maps to the transmembrane domain of hepatitis C virus glycoprotein E2. J. Virol. 72:2183-2191.
6. Danieli, T., S. L. Pelletier, Y. I. Henis, and J. M. White. 1996. Membrane fusion mediated by the influenza hemagglutinin requires the concerted action of at least three hemagglutinin trimers. J. Cell Biol. 133:559-569.
7. Deleersnyder, V., A. Pillez, C. Wychowski, K. Blight, J. Xu, Y. S. Hahn, C. M. Rice, and J. Dubuisson. 1997. Formation of native hepatitis C virus glycoprotein complexes. J. Virol. 71:697-704.
8. Dubuisson, J. Folding, assembly and subcellular localization of HCV glycoproteins. Curr. Top. Microbiol. Immunol., in press.
9. Dubuisson, J., H. H. Hsu, R. C. Cheung, H. B. Greenberg, D. G. Russell, and C. M. Rice. 1994. Formation and intracellular localization of hepatitis C virus envelope glycoprotein complexes expressed by recombinant vaccinia and Sindbis viruses. J. Virol. 68:6147-6160.
10. Flint, M., C. M. Maidens, L. Loomis-Price, C. Shotton, J. Dubuisson, P. Monk, A. Higginbottom, S. Levy, and J. A. McKeating. 1999. Characterization of hepatitis C virus E2 glycoprotein interaction with a putative cellular receptor, CD81. J. Virol. 73:6235-6244.
11. Flint, M., and J. A. McKeating. The C-terminal region of the hepatitis C virus E1 glycoprotein confers localisation within the endoplasmic reticulum. J. Gen. Virol., in press.
12. Gaudin, Y., R. W. H. Ruigrok, and J. Brunner. 1995. Low-pH induced conformational changes in viral fusion proteins: implications for the fusion mechanism. J. Gen. Virol. 76:1541-1556.
13. Gollins, S. W., and J. S. Porterfield. 1986. pH-dependent fusion between the flavivirus West Nile and liposomal model membranes. J. Gen. Virol. 67:157-166.
14. Grakoui, A., C. Wychowski, C. Lin, S. M. Feinstone, and C. M. Rice. 1993. Expression and identification of hepatitis C virus polyprolein cleavage products. J. Virol. 67:1385-1395.
15. Guirakhoo, F., R. A. Bolin, and J. T. Roehrig. 1992. The Murray Valley encephalitis virus prM protein confers acid resistance to virus particles and alters the expression of epitopes within the R2 domain of E glycoprotein. Virology 191:921-931.
16. Guirakhoo, F., F. X. Heinz, C. W. Mandl, H. Holzmann, and C. Kunz. 1991. Fusion activity of flaviviruses: comparison of mature and immature (prM-containing) tick-borne encephalitis virions. J. Gen. Virol. 72:1323-1329.
17. Guirakhoo, F., F. X. Heinz, and C. Kunz. 1989. Epitope model of tick-borne encephalitis virus envelope glycoprotein E: analysis of structural properties, role of carbohydrate side chain, and conformational changes occurring at acidic pH. Virology 169:90-99.
18. Hernandez, L. D., L. R. Hoffman, T. G. Wolfsberg, and J. M. White. 1996. Virus-cell and cell-cell fusion. Annu. Rev. Cell Dev. Biol. 12:627-661.
19. Hijikata, M., N. Kato, Y. Ootsuyama, M. Nakagawa, and K. Shimotohno. 1991. Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis. Proc. Natl. Acad. Sci. USA 88:5547-5551.
20. Horvath, C. M., and R. A. Lamb. 1992. Studies on the fusion peptide of a paramyxovirus fusion glycoprotein: roles of conserved residues in cell fusion. J. Virol. 66:2443-2455.
21. Kimura, T., and A. Ohyama. 1988. Association between the pH-dependent conformational change of West Nile flavivirus E protein and virus-mediated membrane fusion. J. Gen. Virol. 69:1247-1254.
22. Klenk, H.-D., and W. Garten. 1994. Activation cleavage of viral spike proteins by host proteases, p. 241-280. In E. Wimmer (ed.), Cellular receptors for animal viruses. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
23. Lagging, L. M., K. Meyer, R. J. Owens, and R. Ray. 1998. Functional role of hepatitis C virus chimeric glycoproteins in the infectivity of pseudotyped virus. J. Virol. 72:3539-3546.
24. Levy, S., S. C. Todd, and H. T. Maecker. 1998. CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system. Annu. Rev. Immunol. 16:89-109.
25. Lewis, J., P. Balfe, C. Arnold, S. Kaye, R. S. Tedder, and J. A. McKeating. 1998. Development of a neutralizing antibody response during acute primary human immunodeficiency virus type 1 infection and emergence of antigenic variants. J. Virol. 72:8943-8951.
26. Maertens, G., and L. Stuyver. 1997. Genotypes and genetic variation of hepatitis C virus, p. 183-223. In T. J. Harrison & A. J. Zuckerman (eds.) The molecular medicine of viral hepatitis. John Wiley & Sons Ltd., Chichester, United Kingdom.
27. Maidens, C., C. Shotton, M. Flint, J. Dubuisson, J. W. Almond, and J. A. McKeating. 1998. Full length and truncated forms of the HCV E2 glycoprotein differ in both their antigenic conformation and in their ability to recognise their putative cellular receptors, abstr. O032. In Abstracts of the 5th International Meeting of Hepatitis C virus and Related Viruses, Molecular Virology and Pathogenesis 1998.
28. Mason, P. W. 1989. Maturation of Japanese encephalitis virus glycoproteins produced by infected mammalian and mosquito cells. Virology 169:354-364.
29. Matsuura, Y., K. Ishii, H. Aizaki, S. Takigawa, H. Tani, M. A. Whitt, and T. Miyamura. 1998. Characterization of pseudotype VSV possessing HCV envelope proteins, abstr. O006. In Abstracts of the 5th International Meeting of Hepatitis C Virus and Related Viruses, Molecular Virology and Pathogenesis 1998.
30. Matsuura, Y., T. Suzuki, R. Suzuki, M. Sato, H. Aizaki, I. Saito, and T. Miyamura. 1994. Processing of E1 and E2 glycoproteins of hepatitis C virus expressed in mammalian and insect cells. Virology 205:141-150.
31. Michalak, J.-P., C. Wychowski, A. Choukhi, J.-C. Meunier, S. Ung, C. M. Rice, and J. Dubuisson. 1997. Characterization of truncated forms of hepatitis C virus glycoproteins. J. Gen. Virol. 78:2299-2306.
32. Naim, H. Y., and M. G. Roth. 1993. Basis for selective incorporation of glycoproteins into the influenza virus envelope. J. Virol. 67:4831-4841.
33. Nowak, T., P. M. Farber, G. Wengler, and G. Wengler. 1989. Analyses of the terminal sequences of West Nile virus structural proteins and of the in vitro translation of these proteins allow the proposal of a complete scheme of the proteolytic cleavages involved in their synthesis. Virology 169:365-376.
34. Oren, R., S. Takahashi, C. Doss, R. Levy, and S. Levy. 1990. TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins. Mol. Cell. Biol. 10:4007-4015.
35. Paterson, R. G., and R. A. Lamb. 1987. Ability of the hydrophobic fusion-related external domain of a paramyxovirus F protein to act as a membrane anchor. Cell 48:441-452.
36. Pettersson, R. F. 1991. Protein localization and virus assembly at intracellular membranes. Curr. Top. Microbiol. Immunol. 170:67-106.
37. Pileri, P., Y. Uematsu, S. Campagnoli, G. Galli, F. Falugi, R. Petracca, A. J. Weiner, M. Houghton, D. Rosa, G. Grandi, and S. Abrignani. 1998. Binding of hepatitis C virus to CD81. Science 282:938-941.
38. Ralston, R., K. Thudium, K. Berger, C. Kuo, B. Gervase, J. Hall, M. Selby, G. Kuo, M. Houghton, and Q.-L. Choo. 1993. Characterization of hepatitis C virus envelope glycoprotein complexes expressed by recombinant vaccinia viruses. J. Virol. 67:6753-6761.
39. Randolph, V. B., G. Winkler, and V. Stollar. 1990. Acidotropic amines inhibit proteolytic processing of flavivirus prM protein. Virology 174:450-458.
40. Rice, C. M. 1996. Flaviviridae: the viruses and their replication, p. 931-959. In B. N. Fields, D. M. Knipe, P. M. Howley, R. M. Chanock, J. L. Melnick, T. P. Monath, B. Roizman and S. E. Straus (ed.), Fields virology, 3rd ed. Lippincott-Raven, Philadelphia, Pa.
41. Roehrig, J. T., A. J. Johnson, A. R. Hunt, R. A. Bolin, and M. C. Chu. 1990. Antibodies to Dengue 2 virus E-glycoprotein synthetic peptides identify antigenic conformation. Virology 177:668-675.
42. Roehrig, J. T., A. R. Hunt, A. J. Johnson, and R. A. Hawkes. 1989. Synthetic peptides derived from the deduced amino acid sequence of the E-glycoprotein of Murray valley encephalitis virus elicit antiviral antibody. Virology 171:49-60.
43. Rosa, D., S. Campagnoli, C. Moretto, E. Guenzi, L. Cousens, M. Chin, C. Dong, A. J. Weiner, J. Y. N. Lau, Q.-L. Choo, D. Chien, P. Pileri, M. Houghton, and S. Abrignani. 1996. A quantitative test to estimate neutralizing antibodies to the hepatitis C virus: cytofluorimetric assessment of envelope glycoprotein 2 binding to target cells. Proc. Natl. Acad. Sci. USA 93:1759-1763.
44. Santolini, E., G. Migliaccio, and N. L. Monica. 1994. Biosynthesis and biochemical properties of the hepatitis C virus core protein. J. Virol. 68: 3631-3641.
45. Schnell, M. J., L. Buonocore, E. Kretzchmar, E. Johnson, and J. K. Rose. 1996. Foreign glycoproteins expressed from recombinant vesicular stomatitis viruses are incorporated efficiently into virus particles. Proc. Natl. Acad. Sci. USA 93:11359-11365.
46. Selby, M. J., E. Glazer, F. Masiarz, and M. Houghton. 1994. Complex processing and protein:protein interactions in the E2:NS2 region of HCV. Virology 204:114-122.
47. Selby, M. J., Q.-L. Choo, K. Berger, G. Kuo, E. Glazer, M. Eckart, C. Lee, D. Chien, C. Kuo, and M. Houghton. 1993. Expression, identification and subcellular localization of the proteins encoded by the hepatitis C viral genome. J. Gen. Virol. 74:1103-1113.
48. Spaete, R. R., D. A. Alexander, M. E. Rugroden, Q.-L. Choo, K. Berger, K. Crawford, C. Kuo, S. Leng, C. Lee, R. Ralston, K. Thudium, J. W. Tung, G. Kuo, and M. Houghton. 1992. Characterization of the hepatitis C virus E2/NS1 gene product expressed in mammalian cells. Virology 188:819-830.
49. Stadler, K., S. L. Allison, J. Schalich, and F. X. Heinz. 1997. Proteolytic activation of tick-borne encephalitis virus by furin. J. Virol. 71:8475-8481.
50. Stegmann, T., S. Nir, and J. Wilschut. 1989. Membrane fusion activity of influenza virus. Effects of gangliosides and negatively charged phospholipids in target liposomes. Biochemistry 28:1698-1704.
51. White, J. M. 1990. Viral and cellular membrane fusion proteins. Annu. Rev. Physiol. 52:675-697.
52. Zhang, L., and H. P. Ghosh. 1994. Characterization of the putative fusogenic domain in vesicular stomatitis virus glycoprotein G. J. Virol. 68:2186-2193.
53. Zhou, Y., M. König, G. Hobom, and E. Neumeier. 1998. Membrane-anchored incorporation of a foreign protein in recombinant influenza virions. Virology 246:83-94.