Phenotypes of Drosophila homologs of human XPF and XPG to chemically-induced DNA modifications

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 476, Issue 1-2, 2001, Pages 149-165

  Vogel, E W ^a   Nivard, M J M ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Chemical mutagens; Drosophila; Germline; Somatic cells; XP homologs

Indexed keywords

AZIRIDINE; CHLORMETHINE; DNA; EPOXIDE; ETHYLENE OXIDE; IMINE; MESYLIC ACID METHYL ESTER; NITROSOUREA;

ARTICLE; DNA ADDUCT; DNA CROSS LINKING; DNA METHYLATION; DNA MODIFICATION; DNA REPAIR; DROSOPHILA; GENE MUTATION; GERM CELL; MALE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SOMATIC CELL;

ANIMALS; DNA ADDUCTS; DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; DROSOPHILA; ENDONUCLEASES; FEMALE; HUMANS; MALE; MICE; MUTAGENS; MUTATION; NUCLEAR PROTEINS; PHENOTYPE; SPECIES SPECIFICITY; SPERMATOZOA; TRANSCRIPTION FACTORS;

BRASSICACEAE; MAMMALIA;

EID: 0035832369     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(01)00121-X     Document Type: Article

References (75)

1. DNA excision repair
2. DNA repair in eukaryotes
3. Repair of DNA lesions: Mechanisms and relative repair efficiencies
4. Nucleotide excision repair in Escherichia coli
5. Mutagenesis and carcinogenesis in nucleotide excision repair-deficient XPA knock out mice
6. Examining the mechanism of mutagenesis in repair-deficient strains of Drosophila melanogaster
7. AT1 mutant for the timing of DNA repair activity during spermatogenesis
8. D1 on alkylation induced genetic damage in Drosophila
9. Cellular responses to DNA damage in Drosophila melanogaster
10. Characterization by two-endpoint comparisons of the genetic toxicity profiles of vinyl chloride and related etheno-adduct forming carcinogens in Drosophila
11. Nucleophilic selectivity of carcinogens as a determinant of enhanced mutational response in excision repair-defective strains in Drosophila: Effects of 30 carcinogens
12. Genetic analysis of sex chromosomal meiotic mutants in Drosophila melanogaster
13. Isolation and characterization of X-linked mutants of Drosophila melanogaster which are sensitive to mutagens
14. Identification of a second locus in Drosophila melanogaster required for excision repair
15. Photoreactivation rescue and hypermutability of ultraviolet irradiated excision-less Drosophila melanogaster larvae
16. The utilization during mitotic cell division of loci controlling meiotic recombination in Drosophila melanogaster
17. Drosophila mutations at the mei-9 and mus(2)201 loci which block excision of thymine dimers also block induction of unscheduled DNA synthesis by methyl methanesulfonate, ethyl methanesulfonate, N-methyl-N-nitrosourea, UV light and X-rays
18. Correction for differences in germ cell stage sensitivity in risk assessment
19. On recombination-defective meiotic mutants in Drosophila melanogaster
20. The Drosophila meiotic recombination gene mei-9 encodes a homologue of the yeast excision repair protein rad1
21. Positional cloning of the Drosophila melanogaster mei-9 gene, the putative homolog of the Saccharomyces cerevisiae RAD1 gene
22. D1, expressing a truncated XPG protein
23. Nucleotide excision repair endonuclease genes in Drosophila melanogaster
24. Mammalian nucleotide excision repair
25. DNA damage and repair in mutagenesis and carcinogenesis: Implications of structure-activity relationships for cross-species extrapolation
26. Heritable and cancer risks of exposure to anticancer drugs: Inter-species comparisons of covalent deoxyribonucleic acid-binding agents
27. Quantitative correlation of relative rates: Comparison of hydroxide ion with other nucleophilic reagents towards alkyl halides, esters, epoxides and acyl halides
28. How many loci on the X-chromosome of Drosophila melanogaster can mutate to recessive lethals
29. Comparison of blood concentration of 1,3-butadiene and butadiene epoxides in mice and rats exposed to 1,3-butadiene by inhalation
30. The ratio of induced recessive lethals to ring-X loss has prognostic value in terms of functionality of chemical mutagens in Drosophila melanogaster
31. Sequence analysis of N-ethyl-N-nitrosourea induced vermilion mutations on Drosophila melanogaster
32. Effect of nucleotide excision repair on hprt gene mutations in rodent cells exposed to DNA ethylating agents
33. The response of germ cells to ethylene oxide, propylene oxide, propylene imine and methyl methanesulfonate is a matter of cell-stage related DNA repair
34. Dose-response relationships for methyl methanesulfonate in Drosophila melanogaster: DNA methylation per nucleotide vs. sex-linked recessive lethal frequencies
35. Mutagenesis in oocytes of Drosophila melanogaster. I. Scheduled synthesis of nuclear and mitochondrial DNA and unscheduled DNA synthesis
36. Impact of DNA nucleotide excision repair on methyl methanesulfonate-induced mutations in Drosophila melanogaster
37. Genetic damage by bifunctional agents in repair-active premeiotic stages of Drosophila males
38. Mutational spectra induced under distinct excision repair conditions by the 3 methylating agents N-methyl-N-nitrosourea, N-methyl-N′-nitro-N-nitrosoguanidine and N-nitrosodimethylamine in postmeiotic male germ cells of Drosophila
39. Mutational, specificity of ethyl methanesulfonate in excision repair proficient and deficient strains of Drosophila melanogaster
40. Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents
41. 6-alkylguanine-DNA alkyltransferase cDNA
42. Germ cell mutagenesis in Drosophila: Multiple endpoint analysis
43. Repair of O-alkylpyrimidines in mammalian cells: A present consensus
44. In vivo formation and persistence of modified nucleosides resulting from alkylating agents
45. The cytotoxicity DNA crosslinking ability and DNA sequence selectivity of the aniline mustards melphalan, chlorambucil, and 4-[bis(2-chloroethyl)amino]benzoic acid
46. Sequence specificity of alkylation for a series of nitrogen mustard-containing analogues of distamycin of increasing binding site: Evidence for increased toxicity with enhanced sequence specificity
47. Interstrand cross-linking of DNA by difunctional alkylating agents
48. DNA cross-linking and cytotoxicity in normal and transformed human cells treated with antitumor nitrosourea
49. DNA damage and repair in the bone marrow of rats treated with four chloroethylnitrosoureas
50. 16 melanoma cells
51. DNA adducts of N-nitrosoureas
52. 6-methylguanine-DNA methyltransferase activity in breast and brain tumors
53. 6-methylguanine-DNA methyltransferase (MGMT) on the cytotoxic and recombinogenic activity of different antineoplastic drugs
54. O-alkylation in DNA does not correlate with the formation of chromosome breakage events in D. melanogaster
55. Reaction kinetics and biological action in barley of mono-functional methanesulphonic esters
56. DNA damage and repair in somatic and germ cells in vivo, in: Fundamental and molecular mechanisms of mutagenesis
57. All oxygens in nucleic acids react with carcinogenic ethylating agents
58. Chemical mutagenesis
59. Unscheduled DNA synthesis in mammalian germ cells - Its potential use in mutagenicity testing
60. Mechanisms of mutation induction in germ cells of the mouse as assessed by the specific locus test
61. Dose response, repair, and no-effect dose levels in mouse germ-cell mutagenesis
62. Biological basis of germline mutation: Comparison of spontaneous germline mutation rates among Drosophila, mouse, and human
63. The results of Drosophila assays as indications of carcinogen exposure, IARC
64. Somatic eye-colour reversion assay in Drosophila melanogaster using the unstable white-zeste system incorporated with a repair-deficient mutation
65. Genotoxic potency in Drosophila melanogaster of selected aromatic amines and polycyclic aromatic hydrocarbons as assayed in the DNA repair test
66. Genotoxicity in vivo of phenazines and aminophenazines assayed in the wing spot test and the DNA-repair test with Drosophila melanogaster
67. On the use of excision repair defective cells in the wing somatic mutation and recombination test in Drosophila melanogaster
68. A novel method for the parallel monitoring of mitotic recombination and clastogenicity in somatic cells in vivo
69. Performance of 181 chemicals in a Drosophila assay predominantly monitoring interchromosomal mitotic recombination
70. Genotoxic effects of inhaled ethylene oxide, propylene oxide and butylene oxide on germ cells: Sensitivity of genetic endpoints in relation to dose and repair status
71. A deficiency for nucleotide excision repair strongly potentiates the mutagenic effectiveness of methyl bromide in Drosophila