Prevention of venous thromboembolism after knee arthroplasty: A randomized, double-blind trial comparing enoxaparin with warfarin

Annals of Internal Medicine

Volumn 124, Issue 7, 1996, Pages 619-626

  Leclerc, Jacques R ^a   Geerts, William H ^e   Desjardins, Louis ^d   Laflamme, George H ^g   l'Espérance, Bernard ^g   Demers, Christine ^d   Kassis, Jeannine ^f   Cruickshank, Moira ^b   Whitman, Lucinda ^h   Delorme, Fernand ^c  

^a ELI LILLY AND COMPANY   (United States)

^b LONDON HEALTH SCIENCES CENTRE   (Canada)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

^d LAVAL UNIVERSITY   (Canada)

^e SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^f MAISONNEUVE ROSEMONT HOSPITAL   (Canada)

^g HÔPITAL DU SACRÉ COEUR DE MONTRÉAL   (Canada)

^h Health Sciences Centre St John's   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ENOXAPARIN; NONSTEROID ANTIINFLAMMATORY AGENT; WARFARIN;

ADULT; AGED; ARTICLE; BLEEDING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; KNEE ARTHROPLASTY; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SUBCUTANEOUS DRUG ADMINISTRATION; THROMBOCYTOPENIA; THROMBOEMBOLISM;

AGED; ANTICOAGULANTS; DOUBLE-BLIND METHOD; ENOXAPARIN; FEMALE; FOLLOW-UP STUDIES; HEMORRHAGE; HUMANS; KNEE PROSTHESIS; MALE; MIDDLE AGED; POSTOPERATIVE CARE; POSTOPERATIVE COMPLICATIONS; PULMONARY EMBOLISM; THROMBOEMBOLISM; WARFARIN;

EID: 0029989244     PISSN: 00034819     EISSN: None     Source Type: Journal    
DOI: 10.7326/0003-4819-124-7-199604010-00001     Document Type: Article

References (30)

1. Lotke PA, Ecker ML. Alavi A, Berkowitz H. Indications for the treatment of deep venous thrombosis following total knee replacement J Bone Joint Surg [Am] 1984,66 202-8
2. Stulberg BN, Insall JN, Williams GW, Ghelman B. Deep-vein thrombosis following total knee replacement An analysis of six hundred and thirty-eight arthroplasties J Bone Joint Surg [Am]. 1984,66 194-201.
3. Lieberman JR, Geerts WH. Prevention of venous thromboembolism after total hip and knee arthroplasty J Bone Joint Surg [Am] 1994,76 1239-50
4. Cohen SH, Ehrlich GE, Kauffman MS, Cope C. Thrombophlebitis following knee surgery. J Bone Joint Surg [Am] 1973,55:106-12
5. McKenna R, Bachmann F, Kaushal SP, Galante JO. Thromboembolic disease in patients undergoing knee replacement. J Bone Joint Surg [Am]. 1976,58:928-32
6. Hull R, Delmore TJ, Hirsh J, Gent M, Armstrong P, Lofthouse R, et al. Effectiveness of intermittent pulsatile elastic stockings for the prevention of calf and thigh vein thrombosis in patients undergoing elective knee surgery. Thromb Res 1979;16.37-45
7. Stringer MD, Steadman CA, Hedges AR, Thomas EM, Morley TR, Kakkar W. Deep vein thrombosis after elective knee surgery. An incidence study in 312 patients. J Bone Joint Surg [Br]. 1989,71:492-7.
8. Leclerc JR, Geerts WH, Desjardins L, Jobin F, Laroche F, Delorme F, et al. Prevention of deep vein thrombosis after major knee surgery - a randomized, double-blind trial comparing a low molecular weight heparin fragment (enoxaparin) to placebo Thromb Haemost 1992;67:417-23
9. Khaw FM, Moran CG, Pinder IM, Smith SR. The incidence of fatal pulmonary embolism after knee replacement with no prophylactic anticoagulation. J Bone Joint Surg [Br] 1993,75:940-1.
10. Strandness DE Jr, Langlois Y, Cramer M, Randlett A, Thiele BL Long-term sequelae of acute venous thrombosis JAMA 1983;250:1289-92
11. Francis CW, Ricotta JJ, Evarts CM, Marder VJ. Long-term clinical observations and venous functional abnormalities after asymptomatic venous thrombosis following total hip or knee arthroplasty Clin Orthop 1988,232 271-8
12. Bergqvist D, Jendteg S, Lindgren B. Mätzsch T, Persson U. The economics of general thromboembolic prophylaxis World J Surg. 1988,12 349-55
13. Seagroatt V, Tan HS, Goldacre M, Bulstrode C Nugent I, Gill L Elective total hip replacement incidence, emergency readmission rate and postoperative mortality BMJ 1991,303.1431-5
14. McKenna R. Galante J, Bachmann F, Wallace DL, Kaushal SP, Meredith P. Prevention of venous thromboembolism after total knee replacement by high-dose aspirin or intermittent calf and thigh compression Br Med J 1980, 280 514-7
15. Francis CW, Marder VJ, Evarts CM, Yaukoolbodi S. Two-step warfarin therapy. Prevention of postoperative venous thrombosis without excessive bleeding JAMA 1983,249:374-8
16. Francis CW, Pellegrini VD Jr, Stulberg BN, Miller ML, Totterman S, Marder VJ. Prevention of venous thrombosis after total knee arthroplasty Comparison of antithrombm ill and low-dose heparin with dextran J Bone Joint Surg [Am] 1990,72 976-82
17. Haas SB, Insall JN, Scuderi GR, Windsor RE. Ghelman B. Pneumatic sequential-compression boots compared with aspinn prophylaxis of deep-vein thrombosis after total knee arthroplasty J Bone Joint Surg [Am] 1990;72:27-31
18. Hodge WA. Prevention of deep vein thrombosis after total knee arthroplasty Coumadin versus pneumatic compression Clin Orthop 1991;271 101-5.
19. Cushner FD, Friedman RJ. Blood loss in total knee arthroplasty Clin Orthop. 1991;269:98-101.
20. Hull R, Raskob G, Pineo G, Rosenbloom D, Evans W, Mallory T. et al. A comparison of subcutaneous low-molecular-weight heparin with warfarin sodium for prophylaxis against deep-vein thrombosis after hip or knee implantation N Engl J Med 1993,329 1370-6
21. RD heparin compared with warfarin for prevention of venous thromboembolic disease following total hip or knee arthroplasty. RD Heparin Arthroplasty Group. J Bone Joint Surg Am. 1994,76 1174-85
22. Spiro TE, Fitzgerald RH, Trowbridge AA, Overdyke WL, Gardiner GA, Young TR, et al. Enoxaparin a low molecular weight heparin and warfarin for the prevention of venous thromboembolic disease after elective knee replacement surgery [Abstract] Blood 1994,84 246A.
23. Heit J, Berkowitz S, Bona R, Comp P, Corson J, Cushner F, et al. Efficacy and safety of normiflo (a LMWH) for prevention of venous thromboembolism following total knee replacement a double-blind, dose-ranging study [Abstract] Thromb Haemost 1995;73 978A
24. Fauno P, Suomalainen O, Rehnberg V, Hansen TB, Kroner K, Soimakallio S, et al. Prophylaxis for the prevention of venous thromboembolisin after tolal knee arthroplasty A comparison between unfractionated and low-molecular-weight heparin J Bone Joint Surg Am. 1994;76 1814-8.
25. O'Brien PC, Fleming TR. A multiple testing procedure for clinical trials. Biometrics 1979,35 549-56
26. Wells PS, Lensing AW, Davidson BL, Prins MH, Hirsh J. Accuracy of ultrasound for the diagnosis of deep venous thrombosis in asymptomatic patients after orthopedic surgery A meta-analysis. Ann Intern Med. 1995 122:47-53
27. Turpie AG, Levine MN, Hirsh J, Carter O, Jay RM, Powers PJ, et al. A randomized controlled trial of a low molecular weight heparin (enoxapann) to prevent deep vein thrombosis in patients undergoing elective hip surgery N Engl J Med. 1986,315 925-9.
28. Levine MN, Hirsh J, Gent M, Turpie AG, Leclerc JR, Powers P, et al. Prevention of deep vein thrombosis after elective hip surgery A randomized trial comparing low molecular weight heparin with standard unfractionated heparin. Ann Intern Med 1991,114:545-51
29. Spiro TE, Johnson GJ, Christie MJ, Lyons RM, MacFarlane DE, Blasier RB, et al. Efficacy and safety of enoxaparin to prevent deep venous thrombosis after hip replacement surgery Enoxaparin Clinical Trial Group. Ann Intern Med 1994,121 81-9.
30. Colwell CW Jr, Spiro TE, Trowbridge AA, Morris BA, Kwaan HC, Blaha JD, et al. Use of enoxaparin, a low-molecular-weight heparin, and unfractionated heparin for the prevention of deep venous thrombosis after elective hip replacement A clinical trial comparing efficacy and safety Enoxaparin Clinical Trial Group J Bone Joint Surg Am. 1994,76 3-14