Identification of the 6-sulfate binding site unique to α-subunit-containing isozymes of human β-hexosaminidase

Biochemistry

Volumn 40, Issue 18, 2001, Pages 5440-5446

  Sharma, Rohita ^a,b   Deng, Huinan ^a,b   Leung, Amy ^a,b   Mahuran, Don ^a,b  

^a HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SITES;

BINDING ENERGY; CRYSTAL STRUCTURE; DISEASES; ELECTRIC CHARGE; HYDROLYSIS; MUTAGENESIS; NEUROLOGY; PH EFFECTS; REACTION KINETICS;

BIOCHEMISTRY;

ARGININE DERIVATIVE; ASPARAGINE DERIVATIVE; BACTERIAL ENZYME; BETA N ACETYLHEXOSAMINIDASE; BETA N ACETYLHEXOSAMINIDASE A; BETA N ACETYLHEXOSAMINIDASE B; CHITIN DERIVATIVE; CHITOBIASE; GLYCOSIDASE; ISOENZYME; LYSINE DERIVATIVE; SULFATE; UNCLASSIFIED DRUG;

ALPHA CHAIN; ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HUMAN; HYDROLYSIS; KINETICS; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; ARGININE; ASPARAGINE; BETA-N-ACETYLHEXOSAMINIDASE; BINDING SITES; CHO CELLS; CRICETINAE; DISACCHARIDES; HEXOSAMINIDASES; HUMANS; ISOENZYMES; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; SEQUENCE ALIGNMENT; SUBSTRATE SPECIFICITY; TRANSFECTION;

BACTERIA (MICROORGANISMS); MAMMALIA;

EID: 0035826632     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0029200     Document Type: Article

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