A double ring closing metathesis reaction in the rapid, enantioselective synthesis of NK-1 receptor antagonists

Organic Letters

Volumn 3, Issue 5, 2001, Pages 671-674

  Wallace, Debra J ^a   Goodman, Jonathan M ^a,b   Kennedy, Derek J ^a   Davies, Antony J ^a   Cowden, Cameron J ^a   Ashwood, Michael S ^a   Cottrell, Ian F ^a   Dolling, Ulf H ^a   Reider, Paul J ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 OXO 7 AZASPIRODECANE; 1-OXO-7-AZASPIRODECANE; HETEROCYCLIC COMPOUND; NEUROKININ 1 RECEPTOR; SPIRO COMPOUND;

ARTICLE; DRUG ANTAGONISM; HYDROGENATION; STEREOISOMERISM; SYNTHESIS;

AZA COMPOUNDS; HYDROGENATION; RECEPTORS, NEUROKININ-1; SPIRO COMPOUNDS; STEREOISOMERISM;

EID: 0035826378     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol006958g     Document Type: Article

References (33)

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33. Details of modeling studies on the intermediate compounds are provided in the Supporting Information.