Rapid and complete adsorption of unconjugated protein from protein-polysaccharide conjugate vaccines

Vaccine

Volumn 19, Issue 11-12, 2001, Pages 1547-1558

  Shafer, Douglas E ^a   Schuman, Richard F ^a   Lees, Andrew ^a,b,c  

^a Virion Systems Inc   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^c Biosynexus Inc   (United States)

Author keywords

Conjugate vaccines; Protein polysaccharide vaccines; Restricted access media

Indexed keywords

POLYSACCHARIDE VACCINE; PROTEIN;

ADSORPTION; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; FEMALE; GEL FILTRATION; IMMUNOGENICITY; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; TECHNIQUE; ULTRAFILTRATION;

ADSORPTION; ANIMALS; CATTLE; DEXTRANS; FEMALE; HUMANS; MICE; MICE, INBRED BALB C; MOLECULAR WEIGHT; PARTICLE SIZE; POLYSACCHARIDES, BACTERIAL; PROTEINS; RESINS, SYNTHETIC; SERUM ALBUMIN, BOVINE; SILICON DIOXIDE; TETANUS TOXOID; VACCINES, CONJUGATE;

EID: 0035825102     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(00)00383-2     Document Type: Article

References (20)

1. National trends in Haemophilus influenze meningitis mortality and hospitalization among children, 1980 through 1991
2. Glycoprotein conjugate vaccines
3. The introduction of new vaccines into developing countries
4. Immunognenicity of a Streptococcus pneumoniae type 4 polysaccharide-protein conjugate vaccine is decreased by admixture of high doses of free saccharide
5. Immunogneicity of Streptococcus pneumoniae type 6B and 14 polysaccharide-tetanus toxoid conjugates and the effect of uncoupled polysaccharide on the antigen-specific immune response
6. A solid-phase extraction procedure for DNA purification
7. Concentration of dilute protein solutions prior to sodium dodecyl sulfate polyacrylamide gel electrophoresis
8. Activation of soluble polysaccharides with 1-cyano-4-dimethylaminopyridinium tetrafluoroborate for use in protein-polysaccharide conjugate vaccines and immunological reagents
9. Enhanced immunogenicity of protein-dextran conjugates: I. Rapid stimulation of enhanced antibody responses to poorly immunogenic molecules
10. Colorimetric determination of neutral sugars by a resorcinol sulfuric acid micromethod
11. Picogram quantities of anti-Ig antiobodies coupled to dextran induce B cell proliferation
12. The use of restricted-access media in HPLC, Part I Classification and review
13. The use of restricted-access media in HPLC, Part II-Applications
14. Activation of soluble polysaccharides with 1-cyano-4-dimethylaminopyridinium tetrafluoroborate (CDAP) for use in protein-polysaccharide conjugate vaccins and immunological reagents. II. Selective crosslinking of proteins to CDAP-activated polysaccharides
15. Epitopic overload at the site of injection may result in suppression of the immune response to combind capsular polysaccharide conjugate vaccines