Immunogenicity of Streptococcus pneumoniae type 6B and 14 polysaccharide-tetanus toxoid conjugates and the effect of uncoupled polysaccharide on the antigen-specific immune response

Vaccine

Volumn 16, Issue 20, 1998, Pages 1941-1949

  Rodriguez, María E ^a,b   Van Den Dobbelsteen, Germie P J M ^a   Oomen, Lukas A ^a   De Weers, Odo ^a   Van Buren, Leo ^a   Beurret, Michel ^a   Poolman, Jan T ^a,c   Hoogerhout, Peter ^a  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^b FACULTAD DE CIENCIAS EXACTAS   (Argentina)

^c GLAXOSMITHKLINE BIOLOGICALS   (Belgium)

Author keywords

Conjugate vaccine; Immunogenicity; Streptococcus pneumoniae

Indexed keywords

BACTERIAL POLYSACCHARIDE; CARRIER PROTEIN; HAPTEN; IMMUNOGLOBULIN G; OPSONIN; PNEUMOCOCCUS VACCINE; TETANUS TOXOID;

ANIMAL EXPERIMENT; ANTIBODY TITER; ANTIGEN SPECIFICITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG CONJUGATION; DRUG EFFICACY; FEMALE; HELPER CELL; IMMUNE RESPONSE; IMMUNOGENICITY; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PRIORITY JOURNAL; STREPTOCOCCUS PNEUMONIAE; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; ANTIBODIES, BACTERIAL; BACTERIAL CAPSULES; FEMALE; IMMUNOGLOBULIN G; IMMUNOTOXINS; MICE; POLYSACCHARIDES, BACTERIAL; STREPTOCOCCUS PNEUMONIAE; TETANUS TOXOID; VACCINES, CONJUGATE;

EID: 0032400669     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(98)00129-7     Document Type: Article

References (38)

1. 1 Austrian, R., 1984. Pneumococcal infections. In: Germanier, R. (Ed.), Bacterial Vaccines. Academic Press, New York, pp. 257-285.
2. 2 García-Leoni, M.E., Cercenado, E., Rodeño, P., Bernaldo de Quirós, J.C.L., Martínez-Hernández, D. and Bouza, E. Susceptibility of Streptococcus pneumoniae to penicillin: a prospective microbial and clinical study. J. Infect. Dis. 1992, 14(2), 427-435.
3. 3 Musher, D.M. Infections caused by Streptococcus pneumoniae: clinical spectrum, pathogenesis, immunity, and treatment. Clin. Infect. Dis. 1992, 14(4), 801-809.
4. 4 Henrichsen, J. Six newly recognised types of Streptococcus pneumoniae. J. Clin. Microbiol. 1995, 33(10), 2759-2762.
5. 5 Bardardottir, E., Jonsson, S., Jonsdottir, I., Sigfusson, A. and Valdimarsson, H. IgG subclass response and opsonization of Streptococcus pneumoniae after vaccination of healthy adults. J. Infect. Dis. 1990, 162(2), 482-488.
6. 6 Sanders, E.A.M., Rijkers, G.T. and Kuis, W. et al. Defective antipneumococcal polysaccharide antibody response in children with recurrent respiratory tract infections. J. Allergy Clin, Immunol. 1993, 91(1 Pt 1), 110-119.
7. 7 Musher, D.M., Chapman, A.J., Goree, A., Jonsson, S., Briles, D. and Baughn, R.E. Natural and vaccine-related immunity to Streptococcus pneumoniae. J. Infect. Dis. 1986, 154(2), 245-256.
8. 8 Forrester, H.L., Jahnigen, D.W. and LaForce, F.M. Inefficacy of pneumococcal vaccine in a high-risk population. Am. J. Med. 1987, 83(3), 425-430.
9. 9 Shapiro, E.D., Berg, A.T. and Austrian, R. et al. The protective efficacy of polyvalent pneumococcal polysaccharide vaccine. N. Engl. J. Med. 1991, 325(21), 1453-1460.
10. 10 Stein, K.E. Network regulation of the immune response to bacterial polysaccharide antigens. Curr. Top. Microbiol. Immunol. 1985, 119, 57-74.
11. 11 Stein, E.S. Thymus-independent and thymus-dependent responses to polysaccharide antigens. J. Infect. Dis. 1992, 165(suppl 1), S49-52.
12. 12 Alonso de Velasco, E., Merkus, D. and Snippe, H. et al. Synthetic peptides representing T-cell epitopes act as carriers in pneumococcal polysaccharide conjugate vaccines. Infect. Immun. 1995, 63(3), 961-968.
13. 13 Lee, C.-J., Lock, R.A., Andrew, P.W., Timothy, J.M., Hansman, D. and Paton, J.C. Protection of infant mice from challenge with Streptococcus pneumoniae type 19F by immunization with a type 19F polysaccharide-pneumolysoid conjugate. Vaccine 1994, 12(10), 875-878.
14. 14 Schneerson, R., Levi, L., Robbins, J.B., Bryla, D.M., Schiffman, G. and Lagergard, T. Synthesis of a conjugate vaccine composed of pneumococcus type 14 capsular polysaccharide bound to pertussis toxin. Infect. Immun. 1992, 60(9), 3528-3532.
15. 15 Käyhty, H., Åhman, H., Rönnberg, P-H., Tillikainen, R. and Eskola, J.J. Pneumococcal polysaccharide-meningococcal outer membrane protein complex conjugate vaccine is immunogenic in infants and children. J. Infect. Dis. 1995, 172, 1273-1278.
16. 16 Sigurdardottir, S.T., Vidarsson, G. and Gudnason, T. et al. Immune response of infants vaccinated with serotype 6B pneumococcal polysaccharide conjugated with tetanus toxoid. Pediatr. Infect. Dis. J. 1997, 16(7), 667-674.
17. 17 Dagan, R., Melamed, R., Zamir, O. and Leroy, O. Safety and immunogenicity of tetravalent pneumococcal vaccines containing 6B, 14, 19F and 23F polysaccharides conjugated to either tetanus toxoid or diphtheria toxoid in young infants and their boosterability by native polysaccharide antigens. Pediatr. Infect Dis. J. 1997, 16(11), 1053-1059.
18. 18 Åhman, H., Käyhty, H., Tamminen, P., Vuorela, A., Malinoski, F. and Eskola, J. Pentavalent pneumococcal oligosaccharide conjugate vaccine PncCRM is well-tolerated and able to induce an antibody response in infants. Pediatr. Infect. Dis. J. 1996, 15(2), 134-139.
19. 19 Insel, R.A. and Anderson, P.W. Oligosaccharide-protein conjugate vaccines induce and prime for oligoclonal IgG antibody responses to the Haemophilus influenzae type b capsular polysaccharide in human infants. J. Exp. Med. 1986, 163(2), 262-269.
20. 20 Sniadack, D.H., Schwartz, B. and Lipman, H. et al. Potential interventions for prevention of childhood pneumonia: geographic and temporal differences in serotype and serogroup distribution of sterile site pneumococcal isolates from children - implications for vaccine strategies. Pediatr. Infect. Dis. J. 1995, 14(6), 503-510.
21. 21 van Dam, J.E.G., Feer, A. and Snippe, H. Immunogenicity and immunochemistry of Streptococcus pneumoniae capsular polysaccharides. Antonie Leeuwenhoek 1990, 58, 1-47.
22. 22 Peeters, C.A.M., Tenbergen-Meekes, A-M.J., Poolman, J.T., Zegers, B.J.M. and Rijkers, G.T. Immunogenicity of Streptococcus pneumoniae type 4 polysaccharide-protein conjugate vaccine is decreased by admixture of high doses of free saccharide. Vaccine 1992, 10(12), 833-840.
23. 23 de Weers, O., Beurret, M., van Buren, L., Oomen, L. A., Poolman, J.T., Hoogerhout, P., 1998. Application of cystamine and N,N′-bis[glycyl]cystamine as linkers in polysaccharide-protein conjugation. Bioconjugates Chemistry 1998, 9, 309-315.
24. 24 Anttila, M., Eskola, J., Åhman, H., Käyhty, H., 1998. Avidity of IgG for Streptococcus pneumoniae type 6B and 23F polysaccharide in infants primed with pneumococcal conjugates and boostered with polysaccharide or conjugate vaccines. J. Infect. Dis. 1998, 177, 1614-1620.
25. 25 Alonso de Velasco, E., Dekker, B.A.T. and Antal, P. et al. The Quil A improves protection in mice and enhances the opsonic capacity of antisera induced by pneumoccocal polysaccharide conjugates. Vaccine 1994, 12(15), 1419-1422.
26. 26 Raschke, W.C., Baird, S., Ralph, P. and Nakoinz, I. Functional macrophage cell line transformed by Abelson leukaemia virus. Cell 1978, 15(1), 261-267.
27. 27 Pullen, G.R., Fitzgerald, M.G. and Hosking, C.S. Antibody avidity determination by ELISA using thiocyanate elution. J. Immunol. Meth. 1986, 86(1), 83-87.
28. 28 Avery, O.T. and Goebel, W.F. Chemo-immunological studies on conjugated carbohydrate-proteins II. Immunological specificity of synthetic sugar protein antigens. J. Exp. Med 1929, 50, 533-550.
29. 29 Bixler, G.S. and Pillai, S. The cellular basis of the immune response by conjugate vaccines. Contrib. Microbiol. Immunol. 1989, 10, 18-47.
30. 30 Laferrière, C.A., Sood, R.K., de Muys, J-M., Michon, F. and Jennings, H.J. The synthesis of Streptococcus pneumoniae polysaccharide-tetanus toxoid conjugates and the effect of chain length on immunogenicity. Vaccine 1997, 15(2), 179-186.
31. 31 Perlmutter, R.M., Hansburg, D., Briles, D.E., Nicoletti, R.A. and Davie, J.M. Subclass restriction of murine anti-carbohydrate antibodies. J. Immunol. 1978, 121(2), 566-572.
32. 32 Alonso de Velasco, E., Dekker, B.A.T., Verheul, A.F.M., Feldman, R.G., Verhoef, J. and Snippe, H. Anti-polysaccharide immunoglobulin isotype levels and opsonic activity of antisera: relationships with protection against Streptococcus pneumoniae infection in mice. J. Infect. Dis. 1995, 172(2), 562-565.
33. 33 Sela, M., Mozes, E. and Shearer, G.M. Thymus independence of slowly metabolised immunogens. Proc. Natl. Acad. Sci. USA 1972, 69(9), 2696-2700.
34. 34 Moreno, C., 1987. In: Bell, R., Torrigiani, G. (Eds.), Towards Better Carbohydrate Vaccines. J. Wiley, Chichester, UK, pp. 263-277.
35. 35 Howard, J.G., Christie, G.H. and Courtenay, B.M. Treadmill neutralisation of antibody and central inhibition: separate components of pneumococcal polysaccharide paralysis. Transplantation 1970, 10(4), 251-253.
36. 36 Dintzis, R.Z., Middleton, M.H. and Dintzis, H.M. Studies on the immunogenicity and tolerogenicity of T-independent antigens. J. Immunol. 1983, 131(5), 2196-2203.
37. 37 Avery, O.T. and Dubos, R. The protective action of a specific enzyme against type III pneumococcus infection in mice. J. Exp. Med. 1931, 54, 73-90.
38. 38 Brooke, M.S. Breaking of immunological paralysis by injection of specific depolymerase. Nature 1964, 204, 1319-1320.