Platelet inhibition reduces cyclic flow variations and neointimal proliferation in normal and hypercholesterolemic-atherosclerotic canine coronary arteries

Circulation

Volumn 104, Issue 19, 2001, Pages 2331-2337

  Anderson, H Vernon ^a,d   McNatt, Janice ^a   Clubb, Fred J ^a   Herman, Michael ^a   Maffrand, Jean Pierre ^b   DeClerck, Fred ^c   Ahn, Chul ^a   Buja, L Maximilian ^a   Willerson, James T ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b SANOFI   (France)

^c JANSSEN RESEARCH FOUNDATION   (Belgium)

^d UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Arteries; Atherosclerosis; Blood flow; Hypercholesterolemia; Platelets

Indexed keywords

ACETYLSALICYLIC ACID; ANTITHROMBOCYTIC AGENT; CHOLESTEROL; PLATELET DERIVED GROWTH FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY CONSTRICTION; ARTERY INTIMA; ARTERY MEDIA; ARTICLE; ATHEROSCLEROSIS; BLEEDING TIME; CONTROLLED STUDY; CORONARY ARTERY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY DILATATION; DISEASE SEVERITY; HYPERCHOLESTEROLEMIA; NONHUMAN; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; PRIORITY JOURNAL; RESTENOSIS; SUDDEN DEATH; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; THROMBOCYTE KINETICS; THROMBOSIS;

EID: 0035818533     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/hc4401.098434     Document Type: Article

References (38)

1. Migratory activity of human smooth muscle cells cultivated from coronary and peripheral primary and restenotic lesions removed by percutaneous atherectomy
2. Migration of smooth muscle and endothelial cells: Critical events in restenosis
3. Role of platelets in smooth muscle cell proliferation and migration after vascular injury in rat carotid artery
4. Role of platelets in restenosis after percutaneous coronary revascularization
5. Stimulation of aortic smooth muscle cell mitogenesis by serotonin
6. Platelet-induced vascular smooth muscle cell proliferation is modulated by the growth amplification factors serotonin and adenosine diphosphate
7. 2 and vascular smooth muscle cell proliferation
8. 2, and specific receptor antagonists on vascular smooth muscle cell proliferation
9. Vascular smooth muscle proliferation: Synergistic interaction between serotonin and low density lipoproteins
10. Platelet aggregation in partially obstructed vessels and its elimination with aspirin
11. 2 and serotonin mediate coronary blood flow reductions in unsedated dogs
12. Cyclic coronary artery flow in dogs after coronary angioplasty
13. Spontaneous alterations in coronary blood flow velocity before and after coronary angioplasty in patients with severe angina
14. Cyclic flow variations after coronary angioplasty in humans: Clinical and angiographic characteristics and elimination with 7E3 monoclonal antiplatelet antibody
15. Frequency and severity of cyclic flow alternations and platelet aggregation predict the severity of neointimal proliferation following experimental coronary stenosis and endothelial injury
16. Stimulated activation of platelet-derived growth factor receptor in vivo in balloon-injured arteries
17. PDGFβ receptor blockade inhibits intimal hyperplasia in the baboon
18. Inhibition of von Willebrand factor binding to platelet GP lb by a fractionated aurintricarboxylic acid prevents restenosis after vascular injury in hamster carotid artery
19. VCL, an antagonist of the platelet GPlb receptor, markedly inhibits platelet adhesion and intimal thickening after balloon injury in the rat
20. 3 on thrombosis and neointima after oversized porcine coronary angioplasty
21. 2 receptor activation of cyclic flow variations in dogs with severe coronary artery stenoses
22. 2 receptor blockade provide protection against epinephrine-induced cyclic flow variations in severely narrowed canine coronary arteries
23. ADP plays an important role in mediating platelet aggregation and cyclic flow variations in vivo in stenosed and endothelium-canine coronary arteries
24. Inhibition of integrin function by a cyclic RGD-containing peptide prevents neointima formation
25. Oxidized LDL decreases L-arginine uptake and nitric oxide synthase protein expression in human platelets: Relevance of the effect of oxidized LDL on platelet function
26. Low-density lipoproteins inhibit the Na/H antiport in human platelets: A novel mechanism enhancing platelet activity in hypercholesterolemia
27. HMG-CoA reductase inhibition by atorvastatin reduces neointimal inflammation in a rabbit model of atherosclerosis
28. An HMG-CoA reductase inhibitor, cerivastatin, suppresses growth of macrophages expressing matrix metalloproteinases and tissue factor in vivo and in vitro
29. Statins alter smooth muscle cell accumulation and collagen in established atheroma of Watanabe heritable hyperlipidemic rabbits
30. Cyclic flow variations in a conscious dog model of coronary artery stenoses and endothelial injury correlate with acute ischemic heart disease syndromes in humans
31. Arterial remodeling after coronary angioplasty: A serial intravascular ultrasound study
32. Angiographic predictors of neointimal thickening after successful coronary wall healing following percutaneous revascularization
33. Intimal hyperplasia, vascular modeling, and the restenosis problem
34. Atherosclerotic arterial remodeling in the superficial femoral artery: Individual variation in local compensatory enlargement response
35. Increased restenosis in diabetes mellitus after coronary interventions is due to exaggerated intimal hyperplasia
36. Serial follow-up after optimized ultrasound-guided deployment of Palmaz-Schatz stents: In-stent neointimal proliferation without significant reference segment response
37. Bleeding complications with the chimeric antibody to platelet glycoprotein IIb/IIIa integrin in patients undergoing percutaneous coronary intervention
38. Standard versus low-dose weight-adjusted heparin in patients treated with the platelet glycoprotein IIb/IIIa receptor antibody fragment abciximab (c7E3 Fab) during percutaneous coronary revascularization