Proteolytic cleavage of chromogranin A (CgA) by plasmin: Selective liberation of a specific bioactive CgA fragment that regulates catecholamine release

Journal of Biological Chemistry

Volumn 276, Issue 27, 2001, Pages 25022-25029

  Jiang, Qijiao ^a   Taupenot, Laurent ^a   Mahata, Sushil K ^a   Mahata, Manjula ^a   O'Connor, Daniel T ^a   Miles, Lindsey A ^b   Parmer, Robert J ^c  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AFFINITY CHROMATOGRAPHY; CELLS; DESORPTION; ESCHERICHIA COLI; HIGH PRESSURE LIQUID CHROMATOGRAPHY; IONIZATION; MASS SPECTROMETRY; PROTEINS;

PROTEOLYTIC CLEAVAGE;

BIOCHEMISTRY;

CATECHOLAMINE; CHROMOGRANIN A; NICOTINE; PLASMIN; PLASMINOGEN; SYNTHETIC PEPTIDE; CHROMOGRANIN; CHROMOGRANIN A, HUMAN; CHROMOGRANIN A, RAT; PEPTIDE FRAGMENT; RECOMBINANT PROTEIN;

ADRENERGIC SYSTEM; ANIMAL CELL; ARTICLE; AUTOCRINE EFFECT; CHROMAFFIN CELL; CONTROLLED STUDY; ESCHERICHIA COLI; HORMONE ACTION; HUMAN; HUMAN CELL; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NEGATIVE FEEDBACK; NEUROTRANSMITTER RELEASE; NONHUMAN; PHEOCHROMOCYTOMA CELL; PLASMINOGEN ACTIVATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; RAT; REVERSED PHASE LIQUID CHROMATOGRAPHY; STRESS; AFFINITY CHROMATOGRAPHY; AMINO ACID SEQUENCE; ANIMAL; CELL STRAIN; FIBRINOLYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOLATION AND PURIFICATION; MASS SPECTROMETRY; METABOLISM; MOLECULAR GENETICS;

ANIMALIA; ESCHERICHIA COLI;

AMINO ACID SEQUENCE; ANIMALS; CATECHOLAMINES; CHROMATOGRAPHY, AFFINITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMOGRANIN A; CHROMOGRANINS; FIBRINOLYSIS; HUMANS; MOLECULAR SEQUENCE DATA; PC12 CELLS; PEPTIDE FRAGMENTS; PLASMIN; RATS; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 0035816635     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M101545200     Document Type: Article

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