Characterization of a Phospholipase C β2-Binding Site Near the Amino-terminal Coiled-coil of G Protein βγ Subunits

Journal of Biological Chemistry

Volumn 276, Issue 14, 2001, Pages 11246-11251

  Yoshikawa, Daniel M ^b   Bresciano, Karen ^b   Hatwar, Mamata ^b   Smrcka, Alan V ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CROSSLINKING; ENZYME INHIBITION; ENZYMES;

BINDING SITES;

BIOCHEMISTRY;

ALANINE; GUANINE NUCLEOTIDE BINDING PROTEIN; PHOSPHOLIPASE C; PHOSPHOLIPASE C BETA2; PROTEIN SUBUNIT; SUCCINIMIDE DERIVATIVE; SUCCINIMIDYL 4 (N MALEIMIDOMETHYL)CYCLOHEXANE 1 CARBOXYLATE; THIOL GROUP; UNCLASSIFIED DRUG; CROSS LINKING REAGENT; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; ISOENZYME; PHOSPHOLIPASE C BETA; RECOMBINANT PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CROSS LINKING; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; ANIMAL; CHEMISTRY; GENETICS; METABOLISM; MUTATION; PROTEIN BINDING;

ANIMALS; BINDING SITES; CROSS-LINKING REAGENTS; HETEROTRIMERIC GTP-BINDING PROTEINS; ISOENZYMES; MUTATION; PHOSPHOLIPASE C; PROTEIN BINDING; RECOMBINANT PROTEINS;

EID: 0035815732     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M006073200     Document Type: Article

References (21)

1. Hamm, H. E. (1998) J. Biol. Chem. 273, 669-672
2. Gilman, A. G. (1987) Annu. Rev. Biochem. 56, 615-649
3. Lambright, D. G., Sondek, J., Bohm, A., Skiba, N. P., Hamm, H. E., and Sigler, P. B. (1996) Nature 379, 311-319
4. Wall, M. A., Coleman, D. E., Lee, E., Iniguez-Lluhi, J. A., Posner, B. A., Gilman, A. G., and Sprang, S. R. (1995) Cell 83, 1047-1058
5. Ford, C. E., Skiba, N. P., Bae, H., Daaka, Y., Reuveny, E., Shektar, L. R., Rosal, R., Weng, G., Yang, C.-S., Iyengar, R., Miller, R., Jan, L. Y., Lefkowitz, R. J., and Hamm, H. E. (1998) Science 280, 1271-1274
6. Li, Y., Sternweis, P. M., Charnecki, S., Smith, T. F., Gilman, A. G., Neer, E. J., and Kozasa, T. (1998) J. Biol. Chem. 273, 16265-16272
7. Panchenko, M. P., Saxena, K., Li, Y., Charnecki, S., Sternweis, P. M., Smith, T. F., Gilman, A. G., Kozasa, T., and Neer, E. J. (1998) J. Biol. Chem. 273, 28298-28304
8. Buck, E., Li, J., Chen, Y., Weng, G., Scarlata, S., and Iyengar, R. (1999) Science 283, 1332-1335
9. Leberer, E., Dignard, D., Hougan, L., Thomas, D. Y., and Whiteway, M. (1992) EMBO J. 11, 4805-4813
10. Sankaran, B., Osterhout, J., Wu, D., and Smrcka, A. V. (1998) J. Biol. Chem. 273, 7148-7154
11. Garcia-Higuera, I., Thomas, T. C., Yi, F., and Neer, E. J. (1996) J. Biol. Chem. 271, 528-535
12. Romoser, V., Ball, R., and Smrcka, A. V. (1996) J. Biol. Chem. 271, 25071-25078
13. Kozasa, T., and Gilman, A. G. (1995) J. Biol. Chem. 270, 1734-1741
14. Mumby, S. M., and Linder, M. E. (1994) Methods Enzymol. 237, 254-268
15. Smrcka, A. V., and Sternweis, P. C. (1993) J. Biol. Chem. 268, 9667-9674
16. Thomas, T. C., Sladek, T., Yi, F., Smith, T., and Neer, E. J. (1992) Biochemistry 32, 8628-8635
17. Means, G. E., and Feeney, R. E. (1990) Bioconjugate Chem. 1, 2-12
18. Leeuw, T., Wu, C., Schrag, J. D., Whiteway, M., Thomas, D. Y., and Leberer, E. (1998) Nature 391, 191-195
19. Dowell, S. J., Bishop, A. L., Dyos, S. L., Brown, A. J., and Whiteway, M. S. (1998) Genetics 150, 1407-1417
20. Pellegrino, S., Zhang, S., Garritsen, A., and Simonds, W. F. (1998) J. Biol. Chem. 272, 25360-25366
21. Runnels, L. W., and Scarlata, S. F. (1998) Biochemistry 37, 15563-15574