Bioanalysis and preliminary pharmacokinetics of the acridonecarboxamide derivative GF120918 in plasma of mice and humans by ion-pairing reversed-phase high-performance liquid chromatography with fluorescence detection

Journal of Chromatography B: Biomedical Sciences and Applications

Volumn 759, Issue 1, 2001, Pages 135-143

  Kemper, E M ^a   Jansen, B ^a   Brouwer, K R ^b   Schellens, J H M ^a,d   Beijnen, J H ^a,c,d   Van Tellingen, O ^a  

^a ANTONI VAN LEEUWENHOEK HOSPITAL   (Netherlands)

^b GLAXOSMITHKLINE   (United States)

^c NETHERLANDS CANCER INSTITUTE   (Netherlands)

^d UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Acridonecarboxamide; GF120918

Indexed keywords

ACETONITRILE; BIOASSAY; BLOOD; CALIBRATION; ETHERS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METHANOL; PHARMACOKINETICS;

FLUORESCENCE DETECTION;

CHROMATOGRAPHIC ANALYSIS;

ACETONITRILE; ACRIDONE DERIVATIVE; ACRIDONECARBOXAMIDE DERIVATIVE; AMMONIUM ACETATE; BUFFER; CHLORPROMAZINE; ELACRIDAR; GLYCOPROTEIN P; OCTANE; PROTEIN INHIBITOR; SULFONIC ACID DERIVATIVE; TERT BUTYL METHYL ETHER; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG STABILITY; FLUORESCENCE ANALYSIS; HUMAN; INCUBATION TIME; ION PAIR EXTRACTION; LIQUID LIQUID EXTRACTION; MOUSE; NONHUMAN; PH; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SPECTRAL SENSITIVITY; STANDARD; TEMPERATURE;

ACRIDINES; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; ISOQUINOLINES; MICE; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, FLUORESCENCE; TETRAHYDROISOQUINOLINES;

EID: 0035812216     PISSN: 13872273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(01)00207-9     Document Type: Article

References (12)