"Fleximers". Design and synthesis of two novel split nucleosides

Organic Letters

Volumn 3, Issue 20, 2001, Pages 3209-3210

  Seley, Katherine L ^a   Zhang, Liang ^a   Hagos, Asmerom ^a  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; DRUG DERIVATIVE; GUANOSINE; IMIDAZOLE DERIVATIVE; PURINE NUCLEOSIDE; PYRIMIDINE DERIVATIVE;

ARTICLE; CHEMISTRY; SYNTHESIS;

ADENOSINE; GUANOSINE; IMIDAZOLES; PURINE NUCLEOSIDES; PYRIMIDINES;

EID: 0035807545     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol0165443     Document Type: Article

References (11)

1. Leonard, N. J. Acc. Chem. Res. 1982, 15, 128.
2. Leonard, N. J.; Hiremath, S. P. Tetrahedron 1986, 42, 1917.
3. Synthesis of the prox-benzo isomers is presently underway.
4. For the closest nucleoside structure, see: Van Calenbergh, S.; De Bruyn, A.; Schraml, J.; Blaton, N.; Peeters, O.; De Keukeleire, D.; Busson, R.; Herdewijn, P. Nucleosides Nucleotides 1997, 16, 291.
5. Seley, K. L.; Januszczyk, P.; Hagos, A.; Zhang, L.; Dransfield, D. J. Med. Chem. 2000, 43, 4877.
6. Koshkin, A. A.; Singh, S. K.; Nielsen, P.; Rajwanshi, V. K.; Kumar, R.; Meldgaard, M.; Olsen, C. E.; Wengel, J. Tetrahedron 1998, 54, 3607.
7. Czernecki, S.; Georgoulis, C.; Provelenghiou, C. Tetrahedron Lett. 1976, 17, 3535.
8. Sokol, H.; Ritter, J. J. J. Am. Chem. Soc. 1948, 70, 3517.
9. Fuji, K.; Ichikawa, K.; Node, M.; Fujita, E. J. Org. Chem. 1979, 44, 1661.
10. Bennett, S. M.; Nguyen-Ba, N.; Ogilvie, K. K. J. Med. Chem. 1990, 33, 2162.
11. 13C NMR, HRMS, and elemental analyses for all new compounds were consistent with their structures.