Increased tumor necrosis factor-α and nitric oxide production by rat macrophages following in vitro stimulation and intravenous administration of the δ-opioid agonist SNC 80

Life Sciences

Volumn 68, Issue 24, 2001, Pages 2675-2684

  Gomez Flores, Ricardo ^a,c   Rice, Kenner C ^b   Zhang, Xiaoyan ^b   Weber, Richard J ^a,c  

^a UNIVERSITY OF ILLINOIS   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^c UNIVERSIDAD AUTÓNOMA DE NUEVO LEÓN   (Mexico)

Author keywords

Opioid agonist; Macrophages; Nitric oxide; Non peptide opioids; SNC 80; Tumor necrosis factor

Indexed keywords

4 [ALPHA (4 ALLYL 2,5 DIMETHYL 1 PIPERAZINYL) 3 METHOXYBENZYL] N,N DIETHYLBENZAMIDE; CONCANAVALIN A; DELTA OPIATE RECEPTOR AGONIST; LIPOPOLYSACCHARIDE; NITRIC OXIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL SUSPENSION; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENTIATION; IMMUNOCOMPETENCE; IMMUNOREGULATION; IMMUNOSUPPRESSIVE TREATMENT; LYMPHOCYTE FUNCTION; MALE; NONHUMAN; PERITONEUM CELL; PERITONEUM MACROPHAGE; RAT;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; BENZAMIDES; MACROPHAGES, PERITONEAL; MALE; NITRIC OXIDE; PIPERAZINES; RATS; RATS, INBRED F344; RECEPTORS, OPIOID, DELTA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035805145     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(01)01082-7     Document Type: Article

References (43)

1. Zaki PA, Bilsky EJ, Vanderah TW, Lai J, Evans CJ, Porreca F. Opioid receptor types and subtypes: The delta receptor as a model. Annual Reviews on Pharmacology and Toxicology 1996;36:379-401.
2. Heagy W, Teng E, Lopez P, Finberg RW. Enkephalin receptors and receptor-mediated signal transduction in cultured human lymphocytes. Cellular Immunology 1999;191:34-48.
3. Ignatowski TA, Bidlack JM. Detection of kappa opioid receptors on mouse thymocyte phenotypic subpopulations as assessed by flow cytometry. Journal of Pharmacology and Experimental Therapeutics 1998;284:298-306.
4. Carr DJ, Rogers TJ, Weber RJ. The relevance of opioids and opioid receptors on immunocompetence and immune homeostasis. Proceedings of the Society for Experimental Biology and Medicine 1996;213:248-257.
5. Sharp BM, McKean DJ, McAllen K, Shahabi NA. Signaling through delta opioid receptors on murine splenic T cells and stably transfected Jurkat cells. Annals of the New York Academy of Sciences 1998;840:42042-42044.
6. Weber RJ, Pert A. The periaqueductal gray matter mediates opiate-induced immunosuppression. Science 1989;245:188-190.
7. Shavit Y, Depaulis A, Martin FC, Terman GW, Pechnick RN, Zane CJ, Gale RP, Liebeskind JC. Involvement of brain opiate receptors in the immune-suppressive effect of morphine. Proceedings of the National Academy of Sciences USA. 1986;,83,7114-.
8. Gomez-Flores R, Weber RJ. Opioids, opioid receptors, and the immune system. In: Plotnikoff, N, Faith R, Murgo A, Good R, editors. Cytokines, Stress and Immunity. Boca Raton: CRC Press, 1999, pp. 281-314.
9. Roy S, Barke RA, Loh HH. MU-opioid receptor-knockout mice: Role of mu-opioid receptor in morphine mediated immune functions. Brain Research and Molecular Brain Research 1998;61:190-194.
10. Gomez-Flores R, Suo JL, Weber RJ. Suppression of splenic macrophage functions following acute morphine action in the rat mesencephalon periaqueductal gray. Brain Behavior and Immunity 1999;13:212-24.
11. Gomez-Flores R, Weber RJ. Inhibition of interleukin-2 production and downregulation of IL-2 and transferrin receptors on rat splenic lymphocytes following PAG morphine administration: A role in natural killer and T cell suppression. Cytokine and Interferon Research 1999;19:625-360.
12. Rojavin M, Szabo I, Bussiere JL, Rogers TJ, Adler MW, Eisenstein TK. Morphine treatment in vitro or in vivo decreases phagocytic functions of murine macrophages. Life Sciences 1993;53:997-1006.
13. Tubaro E, Avico U, Santiangeli C, Zuccaro P, Cavallo G, Pacifici R, Croce C, Borelli G. Morphine and methadone impact on human phagocytic physiology. International Journal of Immunopharmacology 1985;7:865-74.
14. Hucklebridge FH, Hudspith BN, Lydyard PM, Brostoff J. Stimulation of human peripheral lymphocytes by methionine enkephalin and δ-selective opioid analogues, Immunopharmacology 1990;19:87-91.
15. House RV, Thomas PT, Bhargava HM. A comparative study of immunomodulation produced by in vitro exposure to delta opioid receptor agonist peptides. Peptides 1996;17:75-81.
16. Fóris G, Medgyesi GA, Hauck M. Bidirectional effect of met-enkephalin on macrophage effector functions. Molecular and Cellular Biochemistry 1986;69:127-137.
17. Cameron DJ. Effect of neuropeptides on macrophage mediated cytotoxicity in normal donors and cancer patients. Japanese Journal of Experimental Medicine 1987;57:31-39.
18. Nowak JE, Gomez-Flores R, Calderon SN, Rice KC, Weber RJ. Rat NK cell, T cell, and macrophage functions following intracerebroventricular injection of SNC 80. Journal of Pharmacology and Experimental Therapeutics 1998;286:931-937.
19. Band LC, Pert A, WIlliams W, de Costa BR, Rice KC, Weber RJ. Central μ-opioid receptors mediate suppression of natural killer activity in vivo. Progress in Neuroendocrinimmunology 1992;5:95-101.
20. Kowalski J. Augmenting effect of opioids on nitrite production by stimulated murine macrophages. Neuropeptides 1998;32:287-291.
21. Iuvone T, Capasso A, D'Acquisto F, Carnuccio R. Opioids inhibit the induction of nitric oxide synthase in J774 macrophages. Biochemistry and Biophysical Research Communications 1995;212(3):975-80.
22. Szabo I, Rojavin M, Bussiere JL, Eisenstein TK, Adler MW, Rogers TJ. Suppression of peritoneal macrophage phagocytosis of Candida Albicans by opioids Journal of Pharmacology and Experimental Therapeutics 1993;267(2):703-6.
23. Hambrook JM, Morgan BA, Rance MJ, Smith CF. Mode of deactivation of the enkephalins by rat and human plasma and rat brain homogenates. Nature 1976;262:782-783.
24. Williams W, Rice KC, Weber RJ. Nonpeptide opioids: In vivo effects on the immune system. NIDA Research Monographs 1991;105:404-407.
25. Bilsky EJ, Calderon SN, Wang T, Bernstein RN, Davis P, Hruby VJ, McNutt RW, Rothman RB, Rice KC, Porreca F. SNC 80, a selective, nonpeptidic and systemically active opioid delta agonist. Journal of Pharmacology and Experimental Therapeutics 1995;273:359-366.
26. Calderon SN, Rothman RB, Porreca F, Flippen-Anderson JL, McNutt RW, Xu H, Smith LE, Bilsky EJ, Davis P, Rice KC. Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(alphaR)-alpha- ((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80): A highly selective, nonpeptide delta opioid receptor agonist. Journal of Medical Chemistry 1994;37:2125-8.
27. Kansal R, Gomez-Flores R, Mehta RT. Therapeutic efficacy of liposomal clofazimine against Mycobacterium avium complex (MAC) in mice depends on size of initial inoculum and duration of infection. Antimicrobial Agents and Chemotherapy 1997;41:17-23.
28. Gomez-Flores R, Rodriguez-Padilla C, Mehta RT, Galan-Wong L, Mendoza-Gamboa E, Tamez-Guerra R. Nitric oxide and TNF-α production by murine peritoneal macrophages activated with a novel 20-kDa protein isolated from Bacillus thuringiensis var. thuringiensis parasporal bodies. Journal of Immunology 1997;158:3796-99.
29. Chen T, Scott E, Morrison DC. Differential effects of serum on lipopolysaccharide receptor-directed macrophage activation for nitric oxide production. Immunol Lett 1994;40:179-87.
30. Kaldjian EP, Chen GH, Cease KB. Enhancement of lymphocyte proliferation assays by use of serum-free medium. Journal of Immunological Methods 1992;147:189-95.
31. Belkowski SM, Alicea C, Eisenstein TK, Adler MW, Rogers TJ. Inhibition of interleukin-1 and tumor necrosis factor-alpha synthesis following treatment of macrophages with the kappa opioid agonist U50, 488H. Journal of Pharmacology and Experimental Therapeutics 1995;273:1491-1496.
32. Gomez-Flores R, Tamez-Guerra R, Tucker SD, Mehta RT. Bidirectional effects of IFN-γ on growth of Mycobacterium avium complex in murine peritoneal macrophages. Journal of Interferon and Cytokine Research 1997;17:331-336.
33. Fischer EG. Opioid peptides modulate immune functions. A review. Immunopharmacology and Immunotoxicology 1988;10:265-326.
34. Xia-Zhang L, Xiao E, Ferin M. A 5-day estradiol therapy, in amounts reproducing concentrations of the early-mid follicular phase, prevents the activation of the hypothalamo-pituitary-adrenal axis by interleukin-1 alpha in the ovariectomized rhesus monkey. Journal of Neuroendocrinology 1995;7:387-392.
35. Cohn LA. Glucocorticosteroids as immunosuppressive agents. Seminars on Veterinary Medicinal Surgery 1997;12:150-156.
36. Meltzer MS, Occhionero M, Ruco LP. Macrophage activation for tumor cytotoxicity: Regulatory mechanisms for induction and control of cytotoxic activity. Federation Proceedings 1982;41:2198-2205.
37. Cao Q, Batey R, Pang G, Russell A, Clancy R. IL-6, IFN-gamma and TNF-alpha production by liver-associated T cells and acute liver injury in rats administered concanavalin A. Immunology and Cell Biology 1998;76:542-549.
38. Albina JE, Cui S, Mateo RB, Reichner JS. Nitric oxide-mediated apoptosis in murine peritoneal macrophages. Journal of Immunology 1993;150,5080-5085.
39. Negus SS, Gatch MB, Mello NK, Zhang X, Rice K. Behavioral effects of the delta-selective opioid agonist SNC80 and related compounds in rhesus monkeys. Journal of Pharmacology and Experimental Therapeutics 1998;286:362-375.
40. Sharp BM, Gekker G, Li MD, Chao CC, Peterson PK. Delta-opioid suppression of human immunodeficiency virus-1 expression in T cells (Jurkat). Biochemical Pharmacology 1998;56:289-292.
41. Bencsics A, Elenkov IJ, Vizi ES. Effect of morphine on lipopolysaccharide-induced tumor necrosis factor- Alpha production in vivo: Involvement of the sympathetic nervous system. Journal of Neuroimmunology 1997;73:1-6.
42. Roy S, Charboneau RG, Barke RA. Morphine synergizes with lipopolysaccharide in a chronic endotoxemia model. Journal of Neuroimmunology 1999;95:107-14.
43. Lysle DT, Coussons ME, Watts VJ, Bennett EH, Dykstra LA. Morphine-induced alterations of immune status: Dose dependency, compartment specificity and antagonism by naltrexone. Journal of Pharmacology and Experimental Therapeutics 1993;265:1071-1078.