Antitumor activity and toxicity of novel nitroheterocyclic phosphoramidates

Journal of Medicinal Chemistry

Volumn 44, Issue 1, 2001, Pages 74-77

  Borch, R F ^a,b   Liu, J ^a   Joswig, C ^a   Baggs, R B ^a   Dexter, D L ^c   Mangold, G L ^c  

^a UNIVERSITY OF ROCHESTER   (United States)

^b PURDUE UNIVERSITY   (United States)

^c CTRC Institute for Drug Development   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHOSPHAMIDE; NITROFURYL PHOSPHORAMIDIC ACID; NITROTHIENYL PHOSPHORAMIDIC ACID; PHOSPHORAMIDIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BONE MARROW CELL; BONE MARROW TOXICITY; BREAST CANCER; CONTROLLED STUDY; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG ELIMINATION; DRUG HALF LIFE; ERYTHROID CELL; FEMALE; GRANULOCYTE PRECURSOR; HISTOPATHOLOGY; LEUKEMIA L 1210; LIFESPAN; MACROPHAGE; MELANOMA B16; MOUSE; NONHUMAN; PROMYELOCYTE; SURVIVAL TIME; TUMOR MODEL; TUMOR REGRESSION;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; BONE MARROW CELLS; CELL COUNT; FEMALE; GRANULOCYTES; HETEROCYCLIC COMPOUNDS; HUMANS; MACROPHAGES; MALE; MICE; NITRO COMPOUNDS; PHOSPHORAMIDE MUSTARDS; STEM CELLS; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 0035804313     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000359y     Document Type: Article

References (20)

1. Recent developments in the design of bioreductive drugs
2. Targeting hypoxia with a new generation of indolequinones
3. Cellular pharmacology of quinone bioreductive alkylating agents
4. Aziridinyl nitropyrroles and nitropyrazoles as hypoxia-selective cytotoxins and radiosensitizers
5. Considerations for the design of nitrophenyl mustards as agents with selective toxicity for hypoxic tumor cells
6. Bioreducible mustards: A paradigm for hypoxia-selective prodrugs of diffusible cytotoxins (HPDCs)
7. Synthesis and hypoxia-selective cytotoxicity of a 2-nitroimidazole mustard
8. Hypoxia-selective antitumor agents. 12. Nitrobenzyl quaternary salts as bioreductive prodrugs of the alkylating agent mechlorethamine
9. Nitroheterocycle reduction as a paradigm for intramolecular catalysis of drug delivery to hypoxic cells
10. Nitrobenzyl phosphorodiamidates as potential hypoxia-selective alkylating agents
11. Tumor efficacy and bone marrow-sparing properties of TER286, a cytotoxin activated by glutathione S-transferase
12. Synthesis and evaluation of nitroheterocyclic phosphoramidates as hypoxia-selective alkylating agents
13. Characterization of cytosolic aldehyde dehydrogenase from cyclophosphamide resistant L1210 cells
14. Structure and expression of the cytosolic aldehyde dehydrogenase gene in cyclophosphamide-resistant murine leukemia L1210 cells
15. The role of aldehyde dehydrogenase isozymes in cellular resistance to the alkylating agent cyclophosphamide
16. Role of aldehyde dehydrogenase in cyclophosphamide-resistant L1210 leukemia
17. Direct demonstration of elevated aldehyde dehydrogenase in human hematopoietic progenitor cells
18. Aldehyde dehydrogenase activity as the basis for the relative insensitivity of murine pluripotent hematopoietic stem cells to oxazaphosphorines
19. Myeloprotective effect of diethyldithiocarbamate treatment following 1,3-bis(2-chloroethyl)-1-nitrosourea, adriamycin, or mitomycin C in mice
20. Physical separation of hemopoietic stem cells from cells forming colonies in culture