Activated astrocytes with glycogen accumulation in ischemic penumbra during the early stage of brain infarction: Immunohistochemical and electron microscopic studies

Brain Research

Volumn 909, Issue 1-2, 2001, Pages 92-101

  Kajihara, Hiroki ^a   Tsutsumi, Eriko ^a   Kinoshita, Ayuko ^a   Nakano, Jiro ^a   Takagi, Keiko ^b   Takeo, Satoshi ^b  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

^b TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

Astrocyte activation; Brain infarction; Glycogen accumulation; Ultrastructure

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; GLUCOSE; GLYCOGEN; MICROSPHERE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN INFARCTION; BRAIN REGION; CELL COUNT; CELL DEATH; CELL FUNCTION; CELL STRUCTURE; CELL TRANSFORMATION; CELL VOLUME; CONTROLLED STUDY; CYTOPLASM; ELECTRON MICROSCOPY; ENDOTHELIUM CELL; ENERGY METABOLISM; ENERGY RESOURCE; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; HYPOXIA; IMMUNOHISTOCHEMISTRY; INTERMEDIATE FILAMENT; INTERNAL CAROTID ARTERY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RIGHT HEMISPHERE;

ANIMALS; ASTROCYTES; BRAIN; BRAIN INFARCTION; BRAIN ISCHEMIA; GLIAL FIBRILLARY ACIDIC PROTEIN; GLIOSIS; GLYCOGEN; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY, ELECTRON; NEURONS; RATS; RATS, WISTAR;

EID: 0035800668     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(01)02640-3     Document Type: Article

References (44)

1. Intermediate filament change in astrocytes following mild cortical contusion
2. Immunocytochemical detection of the microsomal glucose-6-phosphatase in human brain astrocytes
3. Association between cell swelling and glycogen content in cultured astrocytes
4. Glycogen in astrocytes: Possible function as lactate supply for neighboring cells
5. Blood-brain barrier glucose transporter is asymmetrically distributed on brain capillary endothelial lumenal and ablumenal membranes: An electron microscopic immunogold study
6. GLUT-1 glucose transporter is present within apical and basolateral membranes of brain epithelial interfaces and in microvascular endothelia with and without tight junctions
7. A role for astrocytes in glucose delivery to neurons?
8. Arachidonate-induced cerebrovascular occlusion in the rat
9. Ultrastructural study of methionine sulfoximine-induced Alzheimer type II astrocytosis
10. The cerebral ischemic penumbra
11. Energy metabolism
12. Regional heterogeneity in the response of astrocytes following traumatic brain injury in the adult rat
13. Brain isozyme of glycogen phosphorylase: Immunohistological localization within the central nervous system
14. Ultrastructure of astrocytes associated with selective neuronal death of cerebral cortex after repeated ischemia
15. Structural organization of the perivascular astrocyte endfeet and their relationship with the endothelial glucose transporter: A confocal microscopy study
16. Astrocytes: Named for their starlike shape, these brain cells were once thought to be little more than passive support elements. Recent findings, however, implicate them in brain function, development and disease
17. Astrocytes
18. Light and electron microscopic study of lipid accumulation along margins of experimental cerebral infarcts in rats
19. Ischemic neuronal injury is ameliorated by astrocyte activation
20. Regulation of glycogen metabolism in astrocytes: Physiological, pharmacological, and pathological aspects
21. Neurotransmitters regulate energy metabolism in astrocytes: Implications for the metabolic trafficking between neural cells
22. The fine structure of astrocytes in the cerebral cortex and their response to focal injury produced by heavy ionizing particles
23. Experimental cerebral infarction: Effect of pentobarbital in Mongolian gerbils
24. Possible therapeutic effect of naftidrofuryl oxalate on brain energy metabolism after microsphere-induced cerebral embolism
25. Sustained decrease in brain regional blood flow after microsphere embolism in rats
26. The human blood-brain barrier glucose transporter (GLUT1) is a glucose transporter of gray matter astrocytes
27. A light and electron microscopic study of experimental portal-systemic (ammonia) encephalopathy
28. The two patterns of reactive astrocytosis in postischemic rat brain
29. Immunocytochemical demonstration of glycogen phosphorylase in rat brain slices
30. Immunohistochemical co-localization of glycogen phosphorylase with the astroglial markers glial fibrillary acidic protein and S-100 protein in rat brain sections
31. An ultrastructural study of methionine sulfoximine-induced glycogen accumulation in astrocytes of the mouse cerebral cortex
32. Regulation of astrocyte morphology by RhoA and lysophosphatidic acid
33. Does astrocytic glycogen benefit axon function and survival in CNS white matter during glucose deprivation?
34. Ultrastructural localization of glycogen phosphorylase predominantly in astrocytes of the gerbil brain
35. Lactate-supported synaptic function in the rat hippocampal slice
36. Deposition of glycogen and changes in some enzymes in brain wounds
37. Immunocytochemical studies of astrocytes following injury to the cerebral cortex of the rat
38. Astrocyte energetics, function and death under conditions of incomplete ischemia: A mechanism of glial death in the penumbra
39. The relationship between CBF, evoked potentials and the clinical features in cerebral ischaemia
40. Sustained damage to energy metabolism of brain regions after microsphere embolism in rats
41. Metabolic coupling between glia and neurons
42. Simulation of aspects of ischemia in cell culture: Changes in lactate compartmentation
43. The effect of trauma on cerebral glycogen and related metabolites and enzymes
44. A culture model of reactive astrocytes: Increased nerve growth factor synthesis and reexpression of cytokine responsiveness