Effect of elevated viscosity in the upper gastrointestinal tract on drug absorption in dogs

European Journal of Pharmaceutical Sciences

Volumn 6, Issue 2, 1998, Pages 131-139

  Reppas, C ^a   Eleftheriou, G ^a   MacHeras, P ^a   Symillides, M ^a   Dressman, J B ^b  

^a UNIVERSITY OF ATHENS   (Greece)

^b GOETHE UNIVERSITY   (Germany)

Author keywords

Binding; Canine model; Cimetidine; Diffusion; Dissolution; Gastrointestinal drug absorption; Guar gum; Hydrochlorothiazide; Mefenamic acid; Paracetamol; Viscosity

Indexed keywords

CIMETIDINE; HYDROCHLOROTHIAZIDE; MEFENAMIC ACID; PARACETAMOL;

ANIMAL EXPERIMENT; ARTICLE; DOG; DRUG ABSORPTION; INTESTINE MUCOSA; NONHUMAN; PRIORITY JOURNAL; UPPER GASTROINTESTINAL TRACT; VISCOSITY;

ACETAMINOPHEN; ANIMALS; AREA UNDER CURVE; CHEMISTRY, PHARMACEUTICAL; CIMETIDINE; DOGS; FEMALE; GALACTANS; GASTRIC EMPTYING; HYDROCHLOROTHIAZIDE; INTESTINAL ABSORPTION; MANNANS; MEFENAMIC ACID; PHARMACOKINETICS; PLANT GUMS; VISCOSITY;

EID: 0032055794     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(97)00077-8     Document Type: Article

References (44)

1. Ameer B., Greenblatt D.J., Divol M.R., Abernethy D.R., Shargel L. High performance liquid chromatography determination of acetaminophen in plasma: single dose pharmacokinetic studies. J. Chromatogr. 226:1981;224-230.
2. Amidon G.L., Lennernäs H., Shah V.P., Crison J.R. A theoretical basis for a biopharmaceutic drug classification: The correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm. Res. 12:1995;413-420.
3. Aronson H. Correction factor for dissolution profile calculations. J. Pharm. Sci. (Letter). 82:1993;1190.
4. Barbahaiya R.H., Phillips T.A., Welling P.G. High performance liquid chromatographic determination of chlorothiazide and hydrochlorothiazide in plasma and urine: preliminary results of clinical studies. J. Pharm. Sci. 70:1981;291-295.
5. Blackburn N.A., Johnson I.T. The effect of guar gum on the viscosity of the gastrointestinal contents and on glucose uptake from the perfused jejunum in the rat. Br. J. Nutr. 46:1981;239-246.
6. Blackburn N.A., Redfern J.S., Jarjis H., Holgate A.M., Hanning I., Scarpello J.H.B., Johnson I.T., Read N.W. The mechanism of action of guar gum in improving glucose tolerance in man. Clin. Sci. 66:1984;329-336.
7. Blackburn N.A., Holgate A.M., Read N.W. Does guar gum improve post-prandial hyperglycemia in humans by reducing small intestinal contact area? Br. J. Nutr. 52:1984;197-204.
8. Braun R.J., Parrott E.L. Influence of viscosity and solubilization on dissolution rate. J. Pharm. Sci. 61:1972;175-178.
9. Brunton, L.L., 1990. Agents for control of gastric acidity and treatment of peptic ulcers. In: Gilman, A.G., Rall, T.W., Nies, A.S., Taylor, P. (Eds.), Goodman and Gilman's, The Pharmacological Basis of Therapeutics, Ch. 37. Pergamon Press, Inc., New York.
10. Clements J.A., Heading R.C., Nimmo W.S., Prescott L.F. Kinetics of acetaminophen absorption and gastric emptying in man. Clin. Pharmacol. Ther. 24:1978;420-431.
11. Dressman, J.B., Yamada, K., 1991. Animal models for oral drug absorption. In: Welling, P.G., Tse F.L.S., Dighe, S. (Eds.), Pharmaceutical Bioequivalence. Marcel Dekker, Inc., New York.
12. Etman M.A., Naggar V.F. Thermodynamics of paracetamol solubility in sugar-water cosolvent systems. Int. J. Pharm. 58:1990;177-184.
13. Franz T.J. Percutaneous absorption. On the relevance of in vitro data. J. Invest. Dermatol. 64:1975;190-195.
14. Glantz, S.A., 1981. Primer of Biostatistics. McGraw-Hill Book Company, NY.
15. Greenwood, D.E., 1994. Small Intestinal pH and Buffer Capacity: Implications for Dissolution of Ionizable Compounds. Ph.D. Thesis, The University of Michigan, College of Pharmacy, Ann Arbor, Michigan.
16. Grijseels H., Crommelin D.J.A., de Blaey C.J. Hydrodynamic approach to dissolution rate. Pharm. Weekbl. (Sci. Ed.). 3:1981;1005-1020.
17. Hewitt R.R., Levy G. Effect of viscosity on thiamine and riboflavin absorption in man. J. Pharm. Sci. 60:1971;784-786.
18. Holt S., Heading R.C., Carter D.C., Prescott L.F., Tothill P. Effect of gel fibre on gastric emptying and absorption of glucose and paracetamol. Lancet. 24 March:1979;636-639.
19. Hunt J.N., Stubbs D.F. The volume and energy content of meals as determinants of gastric emptying. J. Physiol. 245:1975;209-225.
20. Huuponen R., Seppala P., Iisalo E. Effect of guar gum, a fibre preparation on digoxin and penicillin absorption in man. Eur. J. Clin. Pharmacol. 26:1984;279-281.
21. Huuponen R., Karhuvaara S., Seppala P. Effect of guar gum on glipizide absorption in man. Eur J. Clin. Pharmacol. 28:1985;717-719.
22. Imai T., Nohdomi K., Acarturk F., Otagiri M. Enhancement of dissolution and absorption of mefenamic acid by egg albumin. J. Pharm. Sci. 80:1991;484-487.
23. Kaneniwa N., Funaki T., Furuta S., Watari N. Study of the absorption site of cimetidine. J. Pharmacobio-Dyn. 9:1986;321-326.
24. Levich, V.G., 1962. Physicochemical Hydrodynamics. Prentice Hall, Englewood Cliffs, NJ, pp. 60-72.
25. Mummaneni V., Dressman J.B. Intestinal uptake of cimetidine and ranitidine in rats. Pharm. Res. 11:1994;1599-1604.
26. Mummaneni V., Amidon G.L., Dressman J.B. Gastric pH influences the appearance of double peaks in the plasma concentration-time profiles of cimetidine after oral administration in dogs. Pharm. Res. 12:1995;780-786.
27. Oberle R.L., Amidon G.L. Influence of variable gastric emptying and intestinal transit rates on the plasma level curve of cimetidine; an explanation of the double peak phenomenon. J. Pharmacokinet. Biopharm. 15:1987;529-544.
28. Pilch, S.M. (Ed.), 1987. Physiological effects and health consequences of dietary fiber. Life Sciences Research Office, FASEB, Bethesda, MD, USA.
29. Reppas C., Meyer J.H., Sirois P., Dressman J.B. Effect of hydroxypropylmethylcellulose on gastrointestinal transit and luminal viscosity in dogs. Gastroenterology. 100:1991;1217-1223.
30. Reppas C., Greenwood D.E., Dermentzoglou L.C., Meyer T.H., Dressman J.B. Effect of hydroxypropylmethylcellulose on hydrodynamics of nutrient solutions in the canine gastrointestinal tract (1st European Gastroenterology Week Athens, Greece). Hellen. J. Gastroenterol. 5:1992;S-296.
31. Roberts F.G., Smith H.A., Low A.G., Ellis P.R., Morris E.R., Sambrook I.E. Influence of guar gum flour of different molecular weights on viscosity of jejunal digesta in the pig. Proc. Nutr. Soc. 49:1990;53A.
32. Russell J., Bass P. Canine gastric emptying of fiber meals: Influence of meal viscosity and antroduodenal motility. Am. J. Physiol. 249:1985;G662-G667.
33. Sarisuta N., Parrott E.L. Relationship of dissolution rate to viscosity of polymeric solutions. J. Pharm. Sci. 71:1982;1375-1380.
34. Seager H. The effect of methylcellulose on the absorption of nitrofurantoin from the gastrointestinal tract. J. Pharm. Pharmacol. 20:1968;968-969.
35. Seaman, J.K., 1980. Guar Gum. In: Davidson, R.L. (Editor-in-Chief), Handbook of Water-Soluble Gums and Resins, Ch. 6. McGraw-Hill Book Co., NY, USA.
36. Sietsema W.K. The absolute oral bioavailability of selected drugs. Int. J. Clin. Pharm. Ther. Toxicol. 27:1989;179-211.
37. Sirois P.J., Amidon G.L., Meyer J.H., Doty J., Dressman J.B. Gastric emptying of nondigestible solids in dogs: A hydrodynamic correlation. Am. J. Physiol. 258:1990;G65-G72.
38. Soci M.M., Parrott E.L. Influence of viscosity on absorption from nitrofurantoin suspensions. J. Pharm. Sci. 69:1980;403-406.
39. Souchay S., Worner A., Kampffmeyer H.G., Selbmann H.K. Comparison of the pharmacokinetics of phenacetin in beagles after oral and intravenous administration. Eur. J. Drug Metab. Pharm. 1:1976;21-24.
40. 2-receptor antagonist, in the rat, dog, and man. Drug. Metab. Dispos. 6:1978;21-30.
41. TenHoor C.N., Bakatselou V., Dressman J. Solubility of mefenamic acid under simulated fed- and fasted state conditions. Pharm. Res. 8:1991;1203-1205.
42. The Merck Index, 1989. Monograph #4486, 11th ed. Merck & Co., Inc., Rahway, NJ, USA.
43. Welling P.G. Pharmacokinetics of the thiazide diuretics. Biopharm. Drug Dispos. 7:1986;501-535.
44. Wolever T.M.S., Jenkins D.J.A., Nineham R., Alberti K.G.M.M. Guar gum and reduction of postprandial glycemia: Effect of incorporation into solid food, liquid food, and both. Br J. Nutr. 41:1979;505-510.