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note
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A 1:1 mixture of stereoisomers was obtained.
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0043122616
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note
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Calculations (6-31G*) suggest little ground-state energy preference for the s-trans conformation over the s-cis (1.4 kcal/mol) for the imide. In the case of the ester, this preference is considerable (> 16 kcal/mol). (equation presented)
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Determined by analysis of the Mosher amide derivatives of 22 with both (R)- and (S)-MTPA. Dale, J. A.; Dull, D. L.; Mosher, H. S. J. Org. Chem. 1969, 34, 2543-2549.
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