Tandem cationic aza-Cope rearrangement-Mannich cyclization approach to the core structure of FR901483 via a bridgehead iminium ion

Organic Letters

Volumn 3, Issue 9, 2001, Pages 1347-1349

  Brummond, Kay M ^a   Lu, Jianliang ^a  

^a WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOHEXANONE; CYCLOHEXANONE DERIVATIVE; FR 901483; IMMUNOSUPPRESSIVE AGENT; ION; ORGANOPHOSPHORUS COMPOUND;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; CYCLIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION;

CATALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLIZATION; CYCLOHEXANONES; IMMUNOSUPPRESSIVE AGENTS; IONS; MOLECULAR STRUCTURE; ORGANOPHOSPHORUS COMPOUNDS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035799870     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol010029n     Document Type: Article

References (27)

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27. 3, and t-BuOH to afford the desired Boc protected amine in 21% yield. While the yield is low, this reaction sequence provides support for the successful application of this approach to FR901483 and will be optimized.