St. John's wort and drug interactions;Johanniskraut und arzneimittelinteraktionen

Deutsche Apotheker Zeitung

Volumn 141, Issue 31, 2001, Pages 43-46

  Noldner M ^a  

^a DR WILLMAR SCHWABE GMBH AND CO KG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMITRIPTYLINE; CHLOROGENIC ACID; CYCLOSPORIN; CYTOCHROME P450 3A4; DIGOXIN; GLYCOPROTEIN P; HYPERFORIN; HYPERICIN; INDINAVIR; KAEMPFEROL; ORAL CONTRACEPTIVE AGENT; QUERCETIN; THEOPHYLLINE;

DRUG METABOLISM; HERBAL MEDICINE; HYPERICUM PERFORATUM; SHORT SURVEY;

EID: 0035797478     PISSN: 00119857     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (18)

1. Clinical significance of hyperforin for the efficacy of hypericum extracts on depressive disorders of different severities
2. Hypericum treatment of mild-moderate depression in a placebo-controlled study. A prospective, double-blind, randomized, placebo-controlled, multicentre study
3. Hypericum extract versus imipramine or placebo in patients with moderate depression: Randomised multicentre study of treatment for eight weeks
4. Häufigkeit und klinische relevanz der interaktionen und nebenwirkungen von hypericumpräparaten
5. Adverse effects profile of the herbal antidepressant St. John's wort (Hypericum perforatum L.)
6. Second thoughts about safety of St. John's wort
7. Pharmacokinetic interaction of digoxin with an herbal extract from St. John's wort (Hypericum perforatum)
8. Profound drop of cyclosporin a whole blood trough levels caused by St. John's wort (Hypericum perforatum)
9. St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor
10. St. John's wort induces intestinal P-glycoprotein/MDR 1 and intestinal and hepatic CYP3A4
11. Effects of flavonoids on cytochrome P450-dependent acetaminophen metabolism in rats and human liver microsomes
12. Effects of bioflavonoids on hepatic P450 activities
13. In vitro inhibition of midazolam and quinidine metabolism by flavonoids
14. Inhibition of human cytochrome P450 enzymes by constituents of St. John's wort, an herbal preparation used in the treatment of depression
15. In vitro and in vivo activation of oxidative drug metabolism by flavonoids
16. Lack of effect of St. John's wort on carbamazepine pharmacokinetics in healthy volunteers
17. The contribution of P-glycoprotein to pharmacokinetic drug-drug interactions
18. Mechanismen der interaktionen mit johanniskrautextrakten