Effects of glial glutamate transporter inhibitors on intracellular Na+ in mouse astrocytes

Brain Research

Volumn 893, Issue 1-2, 2001, Pages 46-52

  Chatton, Jean Yves ^a   Shimamoto, Keiko ^b   Magistretti, Pierre J ^a  

^a University of Lausanne Medical Center   (Switzerland)

^b SUNTORY INSTITUTE FOR BIOORGANIC RESEARCH   (Japan)

Author keywords

Astrocyte; Fluorescence microscopy; Glutamate transporter inhibitor; Na+ homeostasis

Indexed keywords

2,4 PYRROLIDINEDICARBOXYLIC ACID; 3 HYDROXYASPARTIC ACID; ASPARTIC ACID DERIVATIVE; BENZOFURAN DERIVATIVE; BENZOFURAN ISOPHTALATE; DIHYDROKAINIC ACID; GLUTAMATE TRANSPORTER; GLUTAMIC ACID; SODIUM ION; THREO BETA BENZYLOXYASPARTATE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL CELL; ARTICLE; ASTROCYTE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ELECTROPHYSIOLOGY; IC 50; MOUSE; NONHUMAN; PRIORITY JOURNAL; SODIUM CELL LEVEL; SODIUM TRANSPORT;

AMINO ACID TRANSPORT SYSTEM X-AG; ANIMALS; ASPARTIC ACID; ASTROCYTES; ATP-BINDING CASSETTE TRANSPORTERS; BENZOFURANS; BINDING, COMPETITIVE; CELLS, CULTURED; DICARBOXYLIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHERS, CYCLIC; EXCITATORY AMINO ACID ANTAGONISTS; FLUORESCENT DYES; GLUTAMIC ACID; INTRACELLULAR FLUID; KAINIC ACID; MICE; NEUROTRANSMITTER UPTAKE INHIBITORS; PROTEIN ISOFORMS; PYRROLIDINES; SODIUM; STEREOISOMERISM;

EID: 0035793951     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)03286-8     Document Type: Article

References (20)

1. Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex
2. Electrogenic uptake of glutamate and aspartate into glial cells isolated from the salamander (Ambystoma) retina
3. Glutamate transporter currents in Bergmann glial cells follow the time course of extrasynaptic glutamate
4. + dynamics in mouse cortical astrocytes: Implications for cellular bioenergetics
5. 50) of an enzymatic reaction
6. Trans-inhibition of glutamate transport prevents excitatory amino acid-induced glycolysis in astrocytes
7. 2+ stores in astrocytes: Role of the plasmalemmal Na/Ca exchanger
8. pH, morphology, and diffusion in the lateral intercellular spaces of epithelial cell monolayers
9. Inhibition of uptake unmasks rapid extracellular turnover of glutamate of non-vesicular origin
10. Transmitter receptor and uptake systems in astrocytes and their relation to behaviour
11. New beta-hydroxyaspartate derivatives are competitive blockers for the bovine glutamate/aspartate transporter
12. +-dependent glutamate uptake
13. Energy on demand
14. Neurotransmitter transporters in the central nervous system
15. Heterogeneity and functional properties of subtypes of sodium-dependent glutamate transporters in the mammalian central nervous system
16. Intracellular sodium homeostasis in rat hippocampal astrocytes
17. + changes induced by glutamate, kainate, and D-aspartate in rat hippocampal astrocytes
18. DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters
19. Vasoactive intestinal peptide and noradrenaline exert long-term control on glycogen levels in astrocytes: Blockade by protein synthesis inhibition
20. Glutamate transporters are oxidant-vulnerable: A molecular link between oxidative and excitotoxic neurodegeneration?