Functions of eukaryotic factors in initiation of translation

Cold Spring Harbor Symposia on Quantitative Biology

Volumn 66, Issue , 2001, Pages 389-396

  Pestova, T V ^a,b   Hellen, C U T ^b  

^a MOSCOW STATE UNIVERSITY   (Russian Federation)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLOBIN; INITIATION FACTOR; INITIATION FACTOR 1; INITIATION FACTOR 3; EUKARYOTIC INITIATION FACTOR 5B; GLOBIN MESSENGER RNA; GUANOSINE TRIPHOSPHATE; HEMOGLOBIN BETA CHAIN; INITIATION FACTOR 1A; INITIATION FACTOR 4A; INITIATION FACTOR 5; MESSENGER RNA; UNCLASSIFIED DRUG;

5' UNTRANSLATED REGION; COMPLEX FORMATION; CONFERENCE PAPER; CONFORMATIONAL TRANSITION; DISSOCIATION; EUKARYOTE; GENE STRUCTURE; PRIORITY JOURNAL; PROTEIN RNA BINDING; RNA BINDING; START CODON; TRANSLATION INITIATION; 3' UNTRANSLATED REGION; ARTICLE; BASE PAIRING; BINDING SITE; CELL ADHESION; CODON; HYDROLYSIS; MOLECULAR RECOGNITION; NONHUMAN; PROTEIN FUNCTION; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; RIBOSOME; RIBOSOME SUBUNIT; SEQUENCE HOMOLOGY;

EUKARYOTA;

EID: 0035788027     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.2001.66.389     Document Type: Conference Paper

References (32)

1. Asano K., Clayton J., Shalev A., and Hinnebusch A.G. 2000. A multifactor complex of eukaryotic initiation factors, eIF1, eIF2, eIF3, eIF5 and initiator tRNA(Met) is an important translation initiation intermediate in vivo. Genes Dev. 14: 2534.
2. Battiste J.L., Pestova T.V., Hellen C.U.T., and Wagner G. 2000. The eIF1A solution structure reveals a large RNA-binding surface important for scanning function. Mol. Cell 5: 109.
3. Carter A.P., Clemons W.M., Jr., Brodersen D.E., Morgan-Warren R.J., Hartsch T., Wimberly B.T., and Ramakrishnan V. 2001. Crystal structure of an initiation factor bound to the 30S ribosomal subunit. Science 291: 498.
4. Chaudhuri J., Chowdhury D., and Maitra U. 1999. Distinct functions of eukaryotic translation initiation factors eIF1A and eIF3 in the formation of the 40 S ribosomal preinitiation complex. J. Biol. Chem. 274: 17975.
5. Met functions in directing the scanning ribosome to the start site of translation. Science 242: 93.
6. Met to ribosomes by yIF2, a bacterial IF2 homolog in yeast. Science 280: 1757.
7. Choi S.K., Olsen D.S., Roll-Mecak A., Martung A., Remo K.L., Burley S.K., Hinnebusch A.G., and Dever T.E. 2000. Physical and functional interaction between the eukaryotic orthologs of prokaryotic translation initiation factors IF1 and IF2. Mol. Cell. Biol. 20: 7183.
8. Cui Y., Dinman J.D., Kinzy T.G., and Peltz S.W. 1998. The mof2/Suil protein is a general monitor of translational accuracy. Mol. Cell. Biol. 12: 248.
9. Das S., Maiti T., Das K., and Maitra U. 1997. Specific interaction of eukaryotic translation initiation factor 5 (eIF5) with the β-subunit of eIF2. J. Biol. Chem. 272: 31712.
10. Donahue T.F. 2000. Genetic approaches to translation in Saccharomyces cerevisiae. In Translational control of gene expression. (ed. N. Sonenberg et al.), p. 487. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
11. Fletcher C.M., Pestova T.V., Hellen C.U.T., and Wagner G. 1999. Structure and interactions of the translation initiation factor eIF1. EMBO J 18: 2631.
12. Gunnery S., Mälvali Ü., and Mathews M.B. 1997. Translation of an uncapped mRNA involves scanning. J. Biol. Chem. 272: 21642.
13. Hershey J.W.B. and Merrick W.C. 2000. The pathway and mechanism of initiation of protein synthesis. In Translational control of gene expression (ed. N. Sonenberg et al.), p. 33. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
14. Huang H.-K., Yoon H., Hannig E.M., and Donahue T.F. 1997. GTP hydrolysis controls stringent selection of the AUG start codon during translation initiation in Saccharomyces cerevisiae. Genes Dev. 11: 2396.
15. Kolakofsky D., Ohta T., and Thach R.E. 1968. Junction of the 50S ribosomal subunit with the 30S initiation complex. Nature 220: 244.
16. Kozak M. 1989. The scanning model for translation: An update. J. Cell Biol. 108: 229.
17. -. 1991. Structural features in eukaryotic mRNAs that modulate the initiation of translation. J. Biol. Chem. 266: 19867.
18. Kyrpides N.C. and Woese C.R. 1998. Universally conserved translation initiation factors. Proc. Natl. Acad. Sci. 95: 224.
19. Lee J.H., Choi S.K., Roll-Mecak A., Burley S.K., and Dever T.E. 1999. Universal conservation in translation initiation revealed by human and archaeal homologs of bacterial translation factor IF2. Proc. Natl. Acad. Sci. 96: 1066.
20. Lomakin I.B., Hellen C.U.T., and Pestova T.V. 2000. Physical association of eukaryotic initiation factor 4G (eIF4G) with eIF4A strongly enhances binding of eIF4G to the internal ribosomal entry site of encephalomyocarditis virus and is required for internal initiation of translation. Mol. Cell. Biol. 20: 6019.
21. Marcotrigiano J., Lomakin I.B., Sonenberg N., Pestova T.V., Hellen C.U.T., and Burley S.K. 2001. A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery. Mol. Cell 7: 193.
22. Morino S., Imataka H., Svitkin Y., Pestova T.V., and Sonenberg N. 2000. Eukaryotic translation initiation factor (eIF) 4E binding site and the middle one-third of eIF4GI constitute the core domain for cap-dependent translation, and the C-terminal one-third of eIF4GI functions as a modulatory region. Mol. Cell. Biol. 20: 468.
23. Paulin F.E., Campbell L.E., O'Brien K., Loughlin J., and Proud C.G. 2001. Eukaryotic translation initiation factor 5 (eIF5) acts as a classical GTPase activator protein. Curr. Biol. 11: 55.
24. Pestova T.V. and Hellen C.U.T. 1999. Ribosome recruitment and scanning: What's new? Trends Biochem. Sci. 24: 85.
25. -. 2000. The structure and function of initiation factors in eukaryotic protein synthesis. Cell. Mol. Life Sci. 57: 651.
26. Pestova T.V., Borukhov S.I., and Hellen C.U.T. 1998. Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons. Nature 394: 854.
27. Pestova T.V., Dever T.E., and Hellen C.U.T. 2000a. Ribosomal subunit joining. In Translational control of gene expression (ed. N. Sonenberg et al.), p. 425. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York;
28. Pestova T.V., Lomakin I.B., Lee J.H., Choi S.K., Dever T.E., and Hellen C.U.T. 2000b. The joining of ribosomal subunits in eukaryotes requires eIF5B. Nature 403: 332.
29. Rozen F., Edery I., Meerovitch K., Dever T.E., Merrick W.C., and Sonenberg N. 1990. Bidirectional RNA helicase activity of eukaryotic initiation factors 4A and 4F. Mol. Cell. Biol. 10: 1134.
30. Sette M., van Tilborg P., Spurio R., Kaptein R., Paci M., Gualerzi C.O., and Boelens R. 1997. The structure of the translational initiation factor IF1 from E. coli contains an oligomer-binding motif. EMBO J. 16: 1436.
31. Wilson J., Pestova T.V., Hellen C.U.T., and Sarnow P. 2000. Initiation of protein synthesis from the A site of the ribosome. Cell 102: 511.
32. Met recognition of the start codon. Mol. Cell. Biol. 12: 248.