Reduction of allergic skin responses and serum allergen-specific IgE and IgE-inducing cytokines by drinking deep-sea water in patients with allergic rhinitis

Oto-Rhino-Laryngologia Nova

Volumn 11, Issue 6, 2001, Pages 302-303

  Kimata, Hajime ^a   Tai, Hideyuki ^b   Nakajima, Hiroshi ^b  

^a Unitika Central Hospital   (Japan)

^b Ako Kasei Co Ltd   (Japan)

Author keywords

Allergic rhinitis; Deep sea water; Immunoglobulin E; Interleukin 13; Interleukin 18; Interleukin 4; Skin prick test

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 18; INTERLEUKIN 4; INTERLEUKIN 6; SEA WATER; WATER;

ADULT; ALLERGIC RHINITIS; ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; POLLEN; SKIN ALLERGY; SKIN MANIFESTATION;

EID: 0035787768     PISSN: 10148221     EISSN: None     Source Type: Journal    
DOI: 10.1159/000068306     Document Type: Article

References (7)

1. Tai H, Nakagawa K, Watanabe Y, Yokoyama Y, Nakajima H, Ikegami Y, Nozaki Y, Kikuchi Y: Effect of high mineral water prepared from deep-sea water on human blood pressure and hemorheological parameters. Deep Ocean Water Res 2000;1:53.
2. Emelanov A, Fedoseev G, Barnes PJ: Reduced intracellular magnesium concentrations in asthmatic patients. Eur J Respir 1999;13:38-40.
3. Weglicki WB, Phillips TM: Pathobiology of magnesium deficiency: A cytokine/neurogenic inflammation hypothesis. Am J Physiol 1992;263:R734-R737.
4. Malpuech-Brugere C, Nowacki W, Daveau M, Gueux E, Linard C, Rock E, Leberton J-P, Mazur A, Rayssiguer Y: Inflammatory response following acute magnesium deficiency in the rat. Biochem Biophys Acta 2000;1501:91-98.
5. Kimata H: Effect of humor on allergen-induced wheal reactions. JAMA 2001;285:738.
6. Kimata H, Lindley I, Furusho K: Effect of hydrocortisone on spontaneous IgE and IgG4 production in atopic patients. J Immunol 1995;154:3557-3566.
7. Yoshimoto T, Mizutani, Tsutsui H, Noben-Trauth N, Yamanaka K, Tanaka M, Izumi S, Okamura H, Paul WE, Nakanishi K: IL-18 induction of IgE dependence on CD4+ T cells, IL-4 and STAT6. Nat Immunol 2000;1:132-137.