Ethanol reduces excitability in a subgroup of primary sensory neurons by activation of BKCa channels

European Journal of Neuroscience

Volumn 14, Issue 8, 2001, Pages 1246-1256

  Gruß, Marco ^a   Henrich, Michael ^a   König, Peter ^a   Hempelmann, Gunter ^a   Vogel, Werner ^a   Scholz, Andreas ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Action potential; Analgesia; Calcium activated potassium channel; Dorsal root ganglion; Paresthesia

Indexed keywords

ALCOHOL; BIOCHEMICAL MARKER; CALCIUM ACTIVATED POTASSIUM CHANNEL; DYE; IBERIOTOXIN;

ACTION POTENTIAL; ANALGESIA; ANIMAL CELL; ARTICLE; CELL SIZE; CELL TYPE; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; MALE; MOLECULAR INTERACTION; NERVE CELL EXCITABILITY; NERVE POTENTIAL; NEUROMODULATION; NONHUMAN; PARESTHESIA; PRIORITY JOURNAL; PROBABILITY; RAT; REFRACTORY PERIOD; SENSORY NERVE; SPINAL GANGLION; STAINING;

ACTION POTENTIALS; ALCOHOL-INDUCED DISORDERS, NERVOUS SYSTEM; ANIMALS; CALCIUM; CELL SIZE; CHELATING AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; EGTAZIC ACID; ETHANOL; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GANGLIA, SPINAL; MALE; NERVE FIBERS, MYELINATED; NEURONS, AFFERENT; ORGAN CULTURE TECHNIQUES; PAIN; PATCH-CLAMP TECHNIQUES; PEPTIDES; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; RATS; RATS, WISTAR; REACTION TIME;

EID: 0035783451     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0953-816X.2001.01754.x     Document Type: Article

References (44)

1. Cheng, G., Gao, B.X., Verbny, Y. & Ziskind-Conhaim, L. (1999) Ethanol reduces neuronal excitability and excitatory synaptic transmission in the developing rat spinal cord. Brain Res., 845, 224-231.
2. + current expressed in Xenopus oocytes. Proc.Natl. Acad. Sci. USA, 90, 6957-6960.
3. Covernton, P.J. & Connolly, J.G. (1997) Differential modulation of rat neuronal nicotinic receptor subtypes by acute application of ethanol. Br. J. Pharmacol., 122, 1661-1668.
4. 2+. J. Pharmacol. Exp. Ther., 284, 258-268.
5. Dopico, A.M., Chu, B., Lemos, J.R. & Treistman, S.N. (1999a) Alcohol modulation of calcium-activated potassium channels. Neurochem. Int., 35, 103-106.
6. + channels in isolated neurohypophysal terminals. Mol. Pharmacol., 49, 40-48.
7. + channel subtypes in cell bodies versus nerve endings. J. Physiol. (Lond.), 519, 101-114.
8. Edwards, F.A., Konnerth, A., Sakmann, B. & Takahashi, T. (1989) A thin slice preparation for patch clamp recordings from neurones of the mammalian central nervous system. Pfluegers Arch., 414, 600-612.
9. Gruol, D.L. (1982) Ethanol alters synaptic activity in cultured spinal cord neurons. Brain Res., 243, 25-33.
10. + channel and reduces the firing frequency in sensory neurons. Anaesthesiol. Intensivmed. Notfallmed. Schmerzther., 35, 598-600.
11. Haberberger, R.V. & Bodenbenner, M. (2000) Immunohistochemical localization of muscarinic receptors (M2) in the rat skin. Cell Tissue Res., 300, 389-396.
12. Hamill, O.P., Marty, A., Neher, E., Sakmann, B. & Sigworth, F.J. (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pfluegers Arch., 391, 85-100.
13. Harper, A.A. & Lawson, S.N. (1985a) Conduction velocity is related to morphological cell type in rat dorsal root ganglion neurones. J. Physiol. (Lond.)., 359, 31-46.
14. Harper, A.A. & Lawson, S.N. (1985b) Electrical properties of rat dorsal root ganglion neurones with different peripheral nerve conduction velocities. J. Physiol. (Lond.), 359, 47-63.
15. Harris, R.A. (1999) Ethanol actions on multiple ion channels: Which are important? Alcohol Clin. Exp. Res., 23, 1563-1570.
16. Hille, B. (1992). Ionic Channels of Excitable Membranes. Sinauer Associates, Sunderland, USA.
17. 2+ dependent exocytosis in the somata of dorsal root ganglion neurons. Neuron, 17, 135-145.
18. James, M.F., Duthie, A.M., Duffy, B.L., McKeag, A.M. & Rice, C.P. (1978) Analgesic effect of ethyl alcohol. Br. J. Anaesth., 50, 139-141.
19. Kaczorowski, G.J. & Garcia, M.L. (1999) Pharmacology of voltage-gated and calcium-activated potassium channels. Curr. Opin. Chem. Biol., 3, 448-458.
20. + channels. Nature Neurosci., 2, 1091-1097.
21. Koh, D.S., Reid, G. & Vogel, W. (1994) Activating effect of the flavonoid phloretin on Ca (2+) -activated K+ channels in myelinated nerve fibers of Xenopus laevis. Neurosci. Lett., 165, 167-170.
22. Lancaster, B. & Nicoll, R.A. (1987) Properties of two calcium-activated hyperpolarizations in rat hippocampal neurones. J. Physiol. (Lond.), 389, 187-203.
23. + channels. J. Membr. Biol., 158, 187-196.
24. Lüscher, C., Streit, J., Quadroni, R. & Lüscher, H.R. (1994a) Action potential propagation through embryonic dorsal root ganglion cells in culture. I. Influence of the cell morphology on propagation properties. J. Neurophysiol., 72, 622-633.
25. Lüscher, C., Streit, J., Lipp, P. & Lüscher, H.R. (1994b) Action potential propagation through embryonic dorsal root ganglion cells in culture. II. Decrease of conduction reliability during repetitive stimulation. J. Neurophysiol., 72, 634-643.
26. Martell, A.E. & Smith, R.M. (1975) Critical stability constants. Amines. Plenum Press, New York, pp. 416.
27. Mihic, S.J., Ye, Q., Wick, M.J., Koltchine, V.V., Krasowski, M.D., Finn, S.E., Mascia, M.P., Valenzuela, C.F., Hanson, K.K., Greenblatt, E.P., Harris, R.A. & Harrison, N.L. (1997) Sites of alcohol and volatile anaesthetic action on GABA (A) and glycine receptors. Nature, 389, 385-389.
28. Oakes, S.G. & Pozos, R.S. (1982a) Electrophysiologic effects of acute ethanol exposure. I. Alterations in the action potentials of dorsal root ganglia neurons in dissociated culture. Brain Res., 281, 243-249.
29. Oakes, S.G. & Pozos, R.S. (1982b) Electrophysiologic effects of acute ethanol exposure. II. Alterations in the calcium component of action potentials from sensory neurons in dissociated culture. Brain Res., 281, 251-255.
30. + currents in rat muscle cell culture. Nature, 293, 471-474.
31. Peoples, R.W., Li, C. & Weight, F.F. (1996) Lipid vs protein theories of alcohol action in the nervous system. Annu. Rev. Pharmacol. Toxicol., 36, 185-201.
32. Peoples, R.W. & Weight, F.F. (1995) Cutoff in potency implicates alcohol inhibition of N-methyl-D-aspartate receptors in alcohol intoxication. Proc. Natl. Acad. Sci. USA, 92, 2825-2829.
33. Plenderleith, M.B. & Snow, P.J. (1993) The plant lectin Bandeiraea simplicifolia I-B4 identifies a subpopulation of small diameter primary sensory neurones which innervate the skin in the rat. Neurosci. Lett., 159, 17-20.
34. + channels and their functions in small dorsal root ganglion neurones of rat. J. Physiol. (Lond.), 493, 393-408.
35. + channels in small neurones of rat dorsal root ganglion studied in a thin slice preparation. J. Physiol. (Lond.), 513, 55-69.
36. Scholz, A., Reid, G., Vogel, W. & Bostock, H. (1993) Ion channels in human axons. J. Neurophysiol., 70, 1274-1279.
37. + channel, expressed in oocytes. Biophys. J., 70, 2640-2651.
38. Snider, W.D. & McMahon, S.B. (1998) Tackling pain at the source: New ideas about nociceptors. Neuron, 20, 629-632.
39. Takahashi, T. (1990) Membrane currents in visually identified motoneurones of neonatal rat spinal cord. J. Physiol. (Lond.), 423, 27-46.
40. Treistman, S.N., Bayley, H., Lemos, J.R., Wang, X.M., Nordmann, J.J. & Grant, A.J. (1991) Effects of ethanol on calcium channels, potassium channels, and vasopressin release. Ann. NY Acad. Sci., 625, 249-263.
41. Wong, S.M., Fong, E., Tauck, D.L. & Kendig, J.J. (1997) Ethanol as a general anesthetic: Actions in spinal cord. Eur. J. Pharmacol., 329, 121-127.
42. Woodrow, K.M. & Eltherington, L.G. (1988) Feeling no pain: Alcohol as an analgesic. Pain, 32, 159-163.
43. Wu, J.V. & Kendig, J.J. (1998) Differential sensitivities of TTX-resistant and TTX-sensitive sodium channels to anesthetic concentrations of ethanol in rat sensory neurons. J. Neurosci. Res., 54, 433-443.
44. 2+ chelators in hippocampal CA1 neurons of rat brain slices. J. Neurophysiol., 74, 2225-2241.