Interleukin 10 and its role in the regulation of the cell-mediated immune response in syphilis

Archivum Immunologiae et Therapiae Experimentalis

Volumn 49, Issue 6, 2001, Pages 417-421

  Łusiak, Marzanna ^a   Podwińska, Jadwiga ^a  

^a INSTITUTE OF IMMUNOLOGY AND EXPERIMENTAL THERAPY   (Poland)

Author keywords

Cell mediated immune response; IFN; IL 10; IL 12; IL 2; Nitric oxide; Syphilis

Indexed keywords

INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; NITRIC OXIDE;

CELLULAR IMMUNITY; HUMAN; IMMUNOLOGY; METABOLISM; REVIEW; SYPHILIS; TH2 CELL; TREPONEMA PALLIDUM;

HUMANS; IMMUNITY, CELLULAR; INTERFERONS; INTERLEUKIN-10; INTERLEUKIN-12; INTERLEUKIN-2; NITRIC OXIDE; SYPHILIS; TH2 CELLS; TREPONEMA PALLIDUM;

EID: 0035754837     PISSN: 0004069X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (34)

1. ABBAS A. K., LICHTMAN A. H. and POBER J. S. (1994): Cytokines. Cellular and molecular immunology. Second edition. W. B. Saunders Company, Philadelphia, 239-260.
2. ARROLL T. W., CENTURION-LARA A., LUKEHART S. A. and VAN VOORHIS W. C. (1999): T-cell responses to Treponema pallidum subsp. pallidum antigens during the course of experimental syphilis infection. Infect. Immun., 67, 4757-4763.
3. BAUGHN R. E. (1983): Immunoregulatory effect in experimental syphilis. In SCHELL R. F. and MUSHER D. M. (eds.): Pathogenesis and immunology of treponemal infection. Marcel Dekker Inc., New York, 271-295.
4. CUNHA F. Q., MONCADA S. and LIEW F. Y. (1992): Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by interferon-gamma in murine macrophages. Biochem. Biophys. Res. Commun., 182, 1155-1159.
5. DEMBIŃSKA-KIEĆ A., DULAK J., HARTWICH J., SIEDLECKI A., POLUS M., KRZESZ R., PARTYKA L., DUDEK D., BRZEZIŃSKA A. and GRUCA A. (1996): Influence of oxy-LDL and interleukin-8 on the platelet/PMNs adhesion and on chemotaxis-mediated induction of iNOS in neutrophils. Pol. J. Pharmacol., 48, 93-97.
6. DE WAAL MALEFYT R., HAANEN J., SPITS H., RONCAROLO M. G., TE VELDE A., FIGOR C., JOHNSON K., KASTELEIN R., YSSEL H. and DE VRIES J. E. (1991): Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via down-regulation of class II major histocompatibility complex expression. J. Exp. Med., 174, 915-924.
7. DING A. H., NATHAN C. F. and STUEHR D. J. (1988): Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. J. Immunol., 141, 2407-2412.
8. DING L. and SHEVACH E. M. (1992): IL-10 inhibits mitogen-induced T cell proliferation by selectively inhibiting macrophage costimulatory function. J. Immunol., 148, 3133-3139.
9. FIORENTINO D. F., BOND M. W. and MOSMANN T. R. (1989): Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J. Exp. Med., 170, 2081-2095.
10. FIORENTINO D. F., ZLOTNIK A., MOSMANN T. R., HOWARD M. and O'GARRA A. (1991): IL-10 inhibits cytokine production by activated macrophages. J. Immunol., 147, 3815-3822.
11. FIORENTINO D. F., ZLOTNIK A., VIEIRA P., MOSMANN T. R., HOWARD M., MOORE K. W. and O'GARRA A. (1991): IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells. J. Immunol., 146, 3444-3451.
12. FITZGERALD T. J. and ELMQUIST B. J. (1990): Soluble factors from rabbit spleen cells kill and lyse Treponema pallidum in vitro. Can. J. Microbiol., 36, 711-717.
13. GAZZINELLI R. T., OSWALD I. P., JAMES S. L. and SHER A. (1992): IL-10 inhibits parasite killing and nitrogen oxide production by IFN-gamma-activated macrophages. J. Immunol., 148, 1792-1796.
14. JEANNIN P., DELNESTE Y., SEVESO M., LIFE P. and BONNEFOY J.-Y. (1996): IL-12 synergizes with IL-2 and other stimuli in inducing IL-10 production by human T cells. J. Immunol., 156, 3159-3165.
15. LIEW F. Y., LEE Y., SEVERN A., MILLOT S., SCHMIDT J., SALTER M. and MONCADA S. (1991): A possible novel pathway of regulation by murine T helper type-2 (Th2) cells of a Th1 cell activity via the modulation of the induction of nitric oxide synthase on macrophage. Eur. J. Immunol., 21, 2489-2494.
16. LIEW F. Y., YUN L. and MILLOT S. (1990): TNF-α synergizes with IFN-γ in mediating killing of Leishmania major through the induction of nitric oxide. J. Immunol., 145, 4306-4312.
17. ŁUSIAK M., PODWIŃSKA J. and ŻABA R. (2001): IL-12 i jej rola w odporności przeciwkiłowej. IL-12 and its role in protection against Treponema pallidum. Przegl. Dermatol., 3, 233-242.
18. ŁUSIAK M., PODWIŃSKA J., ŻABA R. and BOWSZYC J. (1999): Tlenek azotu i jego rola w odpowiedzi immunologicznej i odporności w kile. The role of nitric oxide in immunological response of syphilis. Post. Dermatol., 16, 19-41.
19. MARCINKIEWICZ J. (1992): Biologiczna rola tlenku azotu w układzie odpornościowym. Pol. J. Immunol., 17, 45-52.
20. METZGER M., PODWIŃSKA J. and SMOGÓR W. (1977): Cell-mediated immunity in experimental syphilis in rabbits. Arch. Immunol. Ther. Exp., 25, 25-34.
21. MOSMANN T. R. and SAD S. (1996): The expanding universe of T cell subsets: Th1, Th2 and more. Immunol. Today, 17, 138-146.
22. NATHAN C. F., REMOLD H. G. and DAVID J. R. (1973): Characterization of a lymphocyte factor, which alters macrophage functions. J. Exp. Med., 137, 275-290.
23. PEREZ V. L., TRINCHIERI G. and ABBAS A. K. (1996): Cytokines that regulate immune inflammation: interleukin-4, -10 and -12. In AUSTEN K. F.: Therapeutic immunology. Blackwell Science, Inc., Oxford, 238-279.
24. PODWIŃSKA J. (1987): Identification of cells producing anti-treponemal lymphotoxin (ATL). Arch. Immunol. Ther. Exp., 35, 63-70.
25. PODWIŃSKA J. (1991): Circulating immune complexes in experimental syphilis and their relation to immunological response against Treponema pallidum. FEMS Microbiol. Immunol., 76, 83-92.
26. PODWIŃSKA J. (1993): The role of humoral and cell-mediated immunity in protection against Treponema pallidum infection. Arch. Immunol. Ther. Exp., 41, 281-284.
27. PODWIŃSKA J. and CHOMIK M. (1992): Treponemicidal activity of anti-treponemal lymphotoxins and their relation to circulating immune complexes and autolymphocytotoxins. FEMS Microbiol. Immunol., 89, 345-352.
28. PODWIŃSKA J., ŁUSIAK M., ŻABA R. and BOWSZYC J. (2000): The pattern and level of cytokines secreted by Th1 and Th2 lymphocytes of syphilitic patients correlate to the progression of the disease. FEMS Immunol. Med. Microbiol., 28, 1-14.
29. PODWIŃSKA J. and METZGER M. (1981): Treponemicidal activity of supernatants from cultures of sensitized lymphocytes. Arch. Immunol. Ther. Exp., 29, 671-677.
30. PODWIŃSKA J., ŻABA R., ŁUSIAK M. and BOWSZYC J. (1997): Zdolność komórek krwi obwodowej pacjentów do wytwarzania TNF w różnych stadiach kiły. The ability of peripheral blood mononuclear cells of patients to produce TNF in different stages of syphilis. Post. Dermatol., 14, 227-237.
31. ROBAK T. (1995): Biologia i farmakologia cytokin. Wyd. Naukowe PWN, Warszawa-Łódź, 156-163, 171-177, 255-265.
32. TAGA K. and TOSATO G. (1992): IL-10 inhibits human T cell proliferation and IL-2 production. J. Immunol., 148, 1143-1148.
33. TRINCHIERI G. (1997): Cytokines acting on or secreted by macrophages during intracellular infection (IL-10, IL-12, IFN-γ). Curr. Opin. Immunol., 9, 17-23.
34. + T cell clones and peripheral blood cells. J. Immunol., 149, 2378-2384.