Chiral Synthesis and Enzymatic Resolution of (S)-(-)Piperazine-2-Carboxylic Acid Using Enzyme Alcalase

Enantiomer

Volumn 6, Issue 6, 2001, Pages 343-345

  Wu, Guosheng ^a   Zhao, Hua ^b   Luo, Robert G ^b,c   Wei, Dean ^a   Malhotra, Sanjay V ^b  

^a ChemPacific Corporation   (United States)

^b NEW JERSEY INSTITUTE OF TECHNOLOGY   (United States)

^c GTI Novartis   (United States)

Author keywords

(S) piperazine 2 carboxylic acid; Chiral synthesis; Enzymatic resolution; Unnatural amino acid

Indexed keywords

CARBOXYLIC ACID; PIPERAZINE 2 CARBOXYLIC ACID; PIPERAZINE DERIVATIVE; PIPERAZINE-2-CARBOXYLIC ACID; SUBTILISIN;

ARTICLE; CHEMISTRY; HUMAN; MASS FRAGMENTOGRAPHY; STEREOISOMERISM; SYNTHESIS;

CARBOXYLIC ACIDS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; PIPERAZINES; STEREOISOMERISM; SUBTILISINS;

EID: 0035754295     PISSN: 10242430     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. D. Askin, K. K Eng, K. Rossen, R. M. Purick, R P. Well, R P. Volante, and P J. Reider, Tetrahedron Lett. 1994, 35, 673-676.
2. C. F. Bigge, G. Johnson, D. F. Ortwine, J T Drummond, D. M. Retz, L. J. Brahce, F. W. Marcoux, and A. W Probert Jr, J. Med. Chem. 1992, 35, 1371-1384.
3. M. A Bruce, D. R. St Laurent, G. S. Poindexter, I. Monkovic, S. Huang, and N. Balasubramanian, Synth. Commun. 1995, 25, 2673-2684.
4. B. Aebischer, P. Frey, H. P. Haerter, P. L. Herrling, W. Mueller, H. J. Olverman, and J. C. Watleins, Helv. Chim. Acta 1989, 72, 1043-1051.
5. T. Shiraiwa, K. Shinjo, and H. Karokawa, Bull Chem Sos. Jpn. 1991, 64, 3251-3255.
6. A. M. Warshawsky, M V. Patel, and T.-M. Chen, J. Org. Chem. 1997, 62, 0439-0440.
7. E. Eichhorn, J. P. Roduit, N. Shaw, K. Heinzmann, and A. Kiener, Tetrahedron: Asymmetry 1997, 8(15), 2533-2536.