Preparation of (S)-piperazine-2-carboxylic acid, (R)-piperazine-2-carboxylic acid, and (S)-piperidine-2-carboxylic acid by kinetic resolution of the corresponding racemic carboxamides with stereoselective amidases in whole bacterial cells

Tetrahedron Asymmetry

Volumn 8, Issue 15, 1997, Pages 2533-2536

  Eichhorn, Eric ^a   Roduit, Jean Paul ^a   Shaw, Nicholas ^a   Heinzmann, Klaus ^a   Kiener, Andreas ^a  

^a LONZA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDASE; PIPECOLIC ACID; PIPERAZINE DERIVATIVE;

ARTICLE; BACTERIUM; BIOTRANSFORMATION; BURKHOLDERIA; DRUG SYNTHESIS; ENANTIOMER; KLEBSIELLA; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS FLUORESCENS;

EID: 0030790662     PISSN: 09574166     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0957-4166(97)00256-5     Document Type: Article

References (14)

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2. Af Ekenstam, B. T.; Bovin, C. US Patent, 1987, 4,695,576.
3. Patrick, K. S.; Singletary, J. L. Chirality 1991, 3, 208-211.
4. Vecchietti, V.; Giordani, A.; Giardina, G.; Colle, R.; Clarke, G. D. J. Med. Chem. 1991, 34, 397-403.
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9. Shiraiwa, T.; Shinjo, K.; Kurokawa, H. Bull. Chem. Soc. Jpn. 1991, 64, 3251-3255.
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12. (a) Kiener, A.; Roduit, J. P.; Kohr, J.; Shaw, N. 1995, European Patent Application, 0686 698.
13. (b) Kiener, A.; Roduit, J. P.; Heinzmann, K. 1996, PCT Application WO 96/35775 (Eric Eichhorn is not coinventor of these patent applications).
14. Kulla, H. G.; Klausener, F.; Meyer, U.; Lüdeke, B.; Leisinger, T. Arch. Microbiol. 1983, 135, 1-7.